{"id":132240,"date":"2026-02-26T16:55:59","date_gmt":"2026-02-26T15:55:59","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/three-ibec-researchers-receive-grants-from-the-spanish-association-against-cancer\/"},"modified":"2026-02-26T17:02:20","modified_gmt":"2026-02-26T16:02:20","slug":"three-ibec-researchers-receive-grants-from-the-spanish-association-against-cancer","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/tres-investigadors-de-ibec-reben-ajudes-de-associacio-espanyola-contra-el-cancer","title":{"rendered":"Tres investigadors de l’IBEC reben ajudes de l’Associaci\u00f3 Espanyola Contra el C\u00e0ncer"},"content":{"rendered":"\n

Els investigadors de l’IBEC Xavier Rovira-Clav\u00e9, David Esporr\u00edn Ubieto i Ar\u00e1nzazu Villasante lideraran tres projectes de recerca seleccionats per l’Associaci\u00f3 Espanyola Contra el C\u00e0ncer en la seva convocat\u00f2ria d’Ajuts 2025. La cerim\u00f2nia de presentaci\u00f3 dels ajuts, celebrada avui a Barcelona, va recon\u00e8ixer l’impuls d’aquestes iniciatives, que abasten des de plataformes avan\u00e7ades per a ter\u00e0pies cel\u00b7lulars fins a nanomotors intel\u00b7ligents i estrat\u00e8gies innovadores davant tumors pedi\u00e0trics.<\/strong><\/strong><\/p>\n\n\n\n

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L’Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC) ha concedit aquest dijous 26 tres ajudes competitives a investigadors i investigadores de l’IBEC, reconeixent el potencial transformador dels seus projectes en l’\u00e0mbit de la recerca oncol\u00f2gica. Les propostes seleccionades abasten des de noves plataformes per a ter\u00e0pies cel\u00b7lulars fins a nanomotors intel\u00b7ligents i estrat\u00e8gies innovadores per tractar tumors pedi\u00e0trics.<\/p>\n\n\n\n

Els ajuts LAB AECC, Postdoctoral AECC i Sinergies AECC, concedits respectivament a Xavier Rovira Clav\u00e9, David Esporr\u00edn Ubieto i Ar\u00e1nzazu Villasante , formen part de les convocat\u00f2ries anuals amb les quals l’AECC impulsa el talent investigador a Espanya i promou projectes amb clara orientaci\u00f3 translacional. Cada categoria s’adre\u00e7a a una etapa diferent de la carrera cient\u00edfica i incorpora criteris espec\u00edfics orientats a afavorir el desenvolupament de noves l\u00ednies i col\u00b7laboracions estrat\u00e8giques en la lluita contra el c\u00e0ncer.<\/p>\n\n\n\n

Una plataforma per accelerar les ter\u00e0pies CAR-T en tumors s\u00f2lids<\/strong><\/strong><\/h4>\n\n\n
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El projecte liderat per Xavier Rovira-Clav\u00e9 <\/strong>investigador principal del grup de Biotecnologia Espacial de l’IBEC<\/a>, se centra en un dels grans reptes actuals de la immunoter\u00e0pia: aconseguir que les ter\u00e0pies CAR-T siguin eficaces en tumors s\u00f2lids. Tot i que aquesta aproximaci\u00f3 ha demostrat un enorme \u00e8xit en c\u00e0ncers de la sang, el seu impacte en tumors com el melanoma continua sent limitat a causa de barreres f\u00edsiques, un microambient immunosupressor i la capacitat del tumor per modificar els seus ant\u00edgens.<\/p>\n\n\n\n

La proposta planteja el desenvolupament d’una plataforma d’alt rendiment capa\u00e7 d’estudiar, a gran escala, com es comporten diferents versions de c\u00e8l\u00b7lules CAR-T dins del complex entorn d’un tumor s\u00f2lid. Combinant tecnologies com la imatge multiplexada, la microflu\u00eddica, els models tumorals avan\u00e7ats i l’an\u00e0lisi computacional multimodal, l’equip de Rovira-Clav\u00e9 avaluar\u00e0 la infiltraci\u00f3, l’activaci\u00f3 i la persist\u00e8ncia de diferents configuracions de CAR-T, aix\u00ed com els mecanismes d’escapament tumoral.<\/p>\n\n\n\n

L’objectiu final \u00e9s identificar dissenys cel\u00b7lulars m\u00e9s robustos que puguin traslladar-se r\u00e0pidament a futures aplicacions terap\u00e8utiques.<\/p>\n\n\n\n

Nanomotors intel\u00b7ligents per a ter\u00e0pia fotot\u00e8rmica contra el c\u00e0ncer de bufeta<\/strong><\/strong><\/h4>\n\n\n
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David Esporr\u00edn Ubieto<\/strong>, investigador postdoctoral en el grup de Nano Biodispositius Intel\u00b7ligents de l’IBEC<\/a>, desenvolupar\u00e0 un nou tipus de nanomotors org\u00e0nics h\u00edbrids amb capacitats tant diagn\u00f2stiques com terap\u00e8utiques per abordar el c\u00e0ncer de bufeta, una malaltia amb elevats \u00edndexs de recurr\u00e8ncia i tractaments que sovint presenten efectes secundaris significatius.<\/p>\n\n\n\n

La seva proposta combina nanogels intel\u00b7ligents \u2014sensibles a canvis de temperatura, pH o condicions redox\u2014 modificats amb enzims capa\u00e7os d’impulsar aquestes nanopart\u00edcules dins del teixit tumoral gr\u00e0cies a la pres\u00e8ncia d’urea a la bufeta. A m\u00e9s, incorpora nanopart\u00edcules d’or que permeten monitorar en temps real l’avan\u00e7 del tractament mitjan\u00e7ant imatge fotoac\u00fastica i aplicar ter\u00e0pia fotot\u00e8rmica per destruir selectivament les c\u00e8l\u00b7lules tumorals.<\/p>\n\n\n\n

Aquest enfocament multifuncional aborda diverses limitacions de les nanopart\u00edcules actuals i busca obrir noves vies cap a ter\u00e0pies m\u00e9s eficaces i menys invasives.<\/p>\n\n\n\n

Noves ter\u00e0pies per a c\u00e0ncer infantil mitjan\u00e7ant bioenginyeria i immunoter\u00e0pia<\/strong><\/strong><\/h4>\n\n\n
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Ar\u00e1nzazu Villasante, investigadora s\u00e8nior del grup de Nanobioingenieria de l’IBEC<\/a> que ja va rebre una ajuda de l’AECC en la convocat\u00f2ria de 2023<\/a> per desenvolupar un xip experimental destinat a estudiar el neuroblastoma, coordinar\u00e0 ara un projecte col\u00b7laboratiu amb l’Institut d’Investigaci\u00f3 Sanit\u00e0ria Arag\u00f3 (IIS Arag\u00f3) centrat en dos dels c\u00e0ncers pedi\u00e0trics m\u00e9s agressius: el neuroblastoma i el glioma dif\u00fas de l\u00ednia mitjana.<\/p>\n\n\n\n

El projecte SINERGIA proposa dissenyar i caracteritzar nanoanticres capa\u00e7os de recon\u00e8ixer dianes tumorals clau, amb especial atenci\u00f3 a c\u00e8l\u00b7lules associades a la formaci\u00f3 de nous vasos sanguinis, que solen mostrar elevada resist\u00e8ncia a les ter\u00e0pies actuals. Paral\u00b7lelament, es crearan models de laboratori altament biomim\u00e8tics que reprodueixin les condicions f\u00edsiques i biol\u00f2giques de l’entorn tumoral, cosa que permet avaluar de manera m\u00e9s realista l’efic\u00e0cia d’aquests nous tractaments.<\/p>\n\n\n\n

Aquesta col\u00b7laboraci\u00f3 entre l’IBEC i l’IIS Arag\u00f3 integrar\u00e0 bioenginyeria, immunoter\u00e0pia i visi\u00f3 cl\u00ednica per avan\u00e7ar cap a ter\u00e0pies m\u00e9s personalitzades i amb m\u00e9s potencial d’aplicaci\u00f3 real en pacients pedi\u00e0trics.<\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Els investigadors de l’IBEC Xavier Rovira-Clav\u00e9, David Esporr\u00edn Ubieto i Ar\u00e1nzazu Villasante lideraran tres projectes de recerca seleccionats per l’Associaci\u00f3 Espanyola Contra el C\u00e0ncer en la seva convocat\u00f2ria d’Ajuts 2025. La cerim\u00f2nia de presentaci\u00f3 dels ajuts, celebrada avui a Barcelona, va recon\u00e8ixer l’impuls d’aquestes iniciatives, que abasten des de plataformes avan\u00e7ades per a ter\u00e0pies cel\u00b7lulars fins a nanomotors intel\u00b7ligents i estrat\u00e8gies innovadores davant tumors pedi\u00e0trics.<\/p>\n","protected":false},"author":37,"featured_media":132224,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[2072,1774,1927,1136,1878,1140,1818,2095,2082],"post_formats":[],"class_list":["post-132240","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-brain-ca-2","tag-cancer-ca","tag-cancer-de-bufeta","tag-josep-samitier-ca","tag-nanobioengineering-ca","tag-samuel-sanchez-ca","tag-smart-nano-bio-devices-ca","tag-spatial-biotechnology-ca","tag-xavier-rovira-ca"],"yoast_head":"\nTres investigadors de l'IBEC reben ajudes de l'Associaci\u00f3 Espanyola Contra el C\u00e0ncer - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/tres-investigadors-de-ibec-reben-ajudes-de-associacio-espanyola-contra-el-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tres investigadors de l'IBEC reben ajudes de l'Associaci\u00f3 Espanyola Contra el C\u00e0ncer - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Els investigadors de l'IBEC Xavier Rovira-Clav\u00e9, David Esporr\u00edn Ubieto i Ar\u00e1nzazu Villasante lideraran tres projectes de recerca seleccionats per l'Associaci\u00f3 Espanyola Contra el C\u00e0ncer en la seva convocat\u00f2ria d'Ajuts 2025. 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