{"id":132368,"date":"2026-03-02T17:14:11","date_gmt":"2026-03-02T16:14:11","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=132368"},"modified":"2026-03-02T17:31:20","modified_gmt":"2026-03-02T16:31:20","slug":"una-fita-en-el-monitoratge-del-metabolisme-a-temps-real-lequip-de-rmn-del-projecte-bloc-surt-a-la-llum","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-fita-en-el-monitoratge-del-metabolisme-a-temps-real-lequip-de-rmn-del-projecte-bloc-surt-a-la-llum\/","title":{"rendered":"Una fita en el monitoratge del metabolisme a temps real: l&#8217;equip de RMN del Projecte BLOC surt a la llum"},"content":{"rendered":"\n<p><strong>En un avan\u00e7 significatiu per a la tecnologia de laboratori en un xip, investigadors de l&#8217;IBEC dins del marc del projecte europeu BLOC (Benchtop\u00a0NMR\u00a0for\u00a0lab-on\u00a0a-xip), han desenvolupat la primera integraci\u00f3 d&#8217;un espectr\u00f2metre de resson\u00e0ncia magn\u00e8tica nuclear (RMN)\u00a0de sobretaula amb una plataforma de cultiu cel\u00b7lular microflu\u00eddic, amb l&#8217;objectiu de monitorar el metabolisme cel\u00b7lular en temps real. L&#8217;avan\u00e7 ha estat possible per la utilitzaci\u00f3 de t\u00e8cniques de\u00a0RMN\u00a0millorades qu\u00e0nticament que augmenten dr\u00e0sticament la sensibilitat al senyal.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"494\" height=\"430\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/imagen-equipo.png\" alt=\"\" class=\"wp-image-132356 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/imagen-equipo.png 494w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/imagen-equipo-300x261.png 300w\" data-sizes=\"(max-width: 494px) 100vw, 494px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 494px; --smush-placeholder-aspect-ratio: 494\/430;\" \/><figcaption class=\"wp-element-caption\">Foto de l&#8217;espectr\u00f2metre\u00a0RMN\u00a0de sobretaula desenvolupat dins del marc del projecte europeu BLOC.<\/figcaption><\/figure><\/div><\/div>\n<\/div>\n\n\n\n<p>L&#8217;an\u00e0lisi metab\u00f2lica de c\u00e8l\u00b7lules vives <em>in vitro<\/em> \u00e9s fonamental per a comprendre la fisiologia cel\u00b7lular, els mecanismes de les malalties i les respostes als tractaments. Els m\u00e8todes tradicionals per al seguiment del metabolisme solen basar-se en assajos no integrats al proc\u00e9s experimental o en instruments sofisticats d&#8217;alt camp, que s\u00f3n costosos i requereixen grans volums de mostra. La\u00a0espectroscop\u00eda\u00a0de Resson\u00e0ncia Magn\u00e8tica Nuclear (RMN), amb la seva capacitat inigualable per a diferenciar esp\u00e8cies qu\u00edmiques de forma no invasiva, ha prom\u00e8s durant molt de temps una \u00e0mplia comprensi\u00f3 dels processos bioqu\u00edmics, per\u00f2 la seva baixa sensibilitat inherent ha limitat el seu \u00fas en contextos a microescala. Aquest desafiament \u00e9s especialment significatiu en plataformes microflu\u00eddiques, on els volums de mostra s\u00f3n m\u00ednims i els processos metab\u00f2lics evolucionen din\u00e0micament.<br><br>L&#8217;estudi recentment publicat en la revista <em>Analytical Chemistry<\/em> presenta un espectr\u00f2metre de\u00a0RMN\u00a0de sobretaula adaptat per a la dissoluci\u00f3 de Polaritzaci\u00f3 Nuclear Din\u00e0mica (dDNP), una t\u00e8cnica de\u00a0hiperpolaritzaci\u00f3 que potencia la polaritzaci\u00f3 d&#8217;esp\u00edn nuclear molt m\u00e9s all\u00e0 de l&#8217;equilibri t\u00e8rmic, incrementant la intensitat del senyal de\u00a0RMN\u00a0en diversos ordres de magnitud. Aprofitant aquesta millora, els autors van poder superar les limitacions cl\u00e0ssiques de sensibilitat del maquinari compacte de\u00a0RMN\u00a0i detectar canvis metab\u00f2lics en temps real en cultius cel\u00b7lulars que flueixen a trav\u00e9s de dispositius microflu\u00eddics personalitzats. El desenvolupament d&#8217;aquesta nova tecnologia va ser el principal objectiu del <a href=\"https:\/\/blocproject.eu\/\">BLOC:\u00a0RMN\u00a0de laboratori per a l&#8217;a-xip en laboratori<\/a>, un projecte europeu realitzat de l&#8217;1 de gener de 2020 al 31 de desembre de 2023, coordinat per Irene Marco-Rius, investigadora principal del <a href=\"https:\/\/ibecbarcelona.eu\/molecular-imaging-for-precision-medicine\/\">grup d&#8217;Imatge Molecular per a Medicina de Precisi\u00f3<\/a> en l&#8217;Institut de\u00a0Bioinginyeria\u00a0de Catalunya (IBEC).<br><br>La integraci\u00f3 del\u00a0RMN\u00a0de sobretaula amb microflu\u00eddica va implicar una enginyeria acurada del sistema de detecci\u00f3 i el maneig de fluids, permetent observar metab\u00f2lits\u00a0hiperpolaritzats\u00a0introdu\u00efts a l&#8217;entorn de cultiu cel\u00b7lular mentre eren absorbits i transformats per les c\u00e8l\u00b7lules. Aquest enfocament proporciona dades cin\u00e8tiques sobre reaccions metab\u00f2liques sense interrompre el cultiu ni requerir grans poblacions cel\u00b7lulars, un avantatge clau per a estudis de mostres biol\u00f2giques rares o valuoses. Els investigadors van demostrar que era possible observar cont\u00ednuament les conversions metab\u00f2liques crucials, la qual cosa oferia una visi\u00f3 detallada de l&#8217;estat bioqu\u00edmic de les c\u00e8l\u00b7lules estudiades.<br><br>Els resultats suposen una fita per a la\u00a0metabol\u00f3mica\u00a0en un xip: una plataforma compacta i rendible de\u00a0RMN\u00a0capa\u00e7 de permetre l&#8217;observaci\u00f3 directa de fluxos metab\u00f2lics din\u00e0mics en sistemes microflu\u00eddics. Aprofitant la\u00a0hiperpolaritzaci\u00f3, la tecnologia tanca la bretxa entre el rendiment en\u00a0RMN\u00a0d&#8217;alt camp i les necessitats pr\u00e0ctiques de l&#8217;an\u00e0lisi de laboratori en xip, <strong>declara Marc\u00a0Azagra, primer autor de l&#8217;estudi.<br><\/strong><br>De cara al futur, aquesta recerca obre perspectives prometedores per a una \u00e0mplia gamma d&#8217;aplicacions en ci\u00e8ncies de la vida, descobriment de f\u00e0rmacs i medicina de precisi\u00f3. La capacitat de rastrejar vies metab\u00f2liques en temps real en plataformes miniaturitzades podria transformar la forma en qu\u00e8 es dissenyen i interpreten els experiments, permetent estudis longitudinals de respostes cel\u00b7lulars, cribatge d&#8217;alt rendiment de moduladors metab\u00f2lics i integraci\u00f3 amb altres m\u00f2duls de laboratori en xip, com a teixits que mimetitzen \u00f2rgans.<br><br>A mesura que la tecnologia de\u00a0RMN\u00a0de laboratori continua madurant, la seva combinaci\u00f3 amb microflu\u00eddica i\u00a0hiperpolaritzaci\u00f3\u00a0podria convertir-se en una eina crucial per l&#8217;an\u00e0lisi biol\u00f2gic din\u00e0mic, aportant informaci\u00f3 espectrosc\u00f2pica rica directament a l&#8217;escala de microambients cel\u00b7lulars, <strong>conclou Irene Marco-Rius.<\/strong><\/p>\n\n\n\n<p><em>El projecte BLOC ha estat finan\u00e7at pel programa \u201cEuropean Union\u2019s Horizon 2020 research and innovation\u201d, sota el n\u00famero 863037.<\/em><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-medium\"><img decoding=\"async\" width=\"300\" height=\"63\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/EU-logo-300x63.jpg\" alt=\"\" class=\"wp-image-132359 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/EU-logo-300x63.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/EU-logo-1024x215.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/EU-logo-768x161.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/03\/EU-logo.jpg 1100w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/63;\" \/><\/figure><\/div><\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Article de refer\u00e8ncia<\/strong><br>Marc Azagra, Hetal Patel, Alejandro Portela, Dian Weerakonda, Behdad Aghelnejad, Jose Yeste, Gerg\u0151 Matajsz, Marc Dubois, Matthew Fallon, Tryfon Antonakakis, Javier Ram\u00f3n-Azc\u00f3n, Irene Marco-Rius.\u00a0<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c04319\">Lab-on-a-Chip Metabolic Analysis Using Benchtop NMR Technology<\/a>. Anal. Chem. 2026, 98, 2701\u22122708, DOI 10.1021\/acs.analchem.5c04319<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>En un avan\u00e7 significatiu per a la tecnologia de laboratori en un xip, investigadors de l&#8217;IBEC dins del marc del projecte europeu BLOC (Benchtop\u00a0NMR\u00a0for\u00a0lab-on\u00a0a-xip), han desenvolupat la primera integraci\u00f3 d&#8217;un &#8230; <a title=\"Una fita en el monitoratge del metabolisme a temps real: l&#8217;equip de RMN del Projecte BLOC surt a la llum\" class=\"read-more\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-fita-en-el-monitoratge-del-metabolisme-a-temps-real-lequip-de-rmn-del-projecte-bloc-surt-a-la-llum\/\" aria-label=\"More on Una fita en el monitoratge del metabolisme a temps real: l&#8217;equip de RMN del Projecte BLOC surt a la llum\">Read more<\/a><\/p>\n","protected":false},"author":24,"featured_media":132356,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1122],"post_formats":[],"class_list":["post-132368","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-irene-marco-rius-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Una fita en el monitoratge del metabolisme a temps real: l&#039;equip de RMN del Projecte BLOC surt a la llum - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-fita-en-el-monitoratge-del-metabolisme-a-temps-real-lequip-de-rmn-del-projecte-bloc-surt-a-la-llum\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una fita en el monitoratge del metabolisme a temps real: l&#039;equip de RMN del Projecte BLOC surt a la llum - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En un avan\u00e7 significatiu per a la tecnologia de laboratori en un xip, investigadors de l&#8217;IBEC dins del marc del projecte europeu BLOC (Benchtop\u00a0NMR\u00a0for\u00a0lab-on\u00a0a-xip), han desenvolupat la primera integraci\u00f3 d&#8217;un ... 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