{"id":133371,"date":"2026-04-29T11:00:00","date_gmt":"2026-04-29T09:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=133371"},"modified":"2026-04-29T11:21:47","modified_gmt":"2026-04-29T09:21:47","slug":"how-cells-decide-when-to-react-could-shape-future-treatments-for-cancer-and-fibrosis","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/la-forma-en-que-les-cel%C2%B7lules-decideixen-quan-reaccionar-podria-influir-en-futurs-tractaments-per-al-cancer-i-la-fibrosi","title":{"rendered":"La forma en qu\u00e8 les c\u00e8l\u00b7lules decideixen quan reaccionar podria influir en futurs tractaments per al c\u00e0ncer i la fibrosi"},"content":{"rendered":"\n

Cient\u00edfics de l’Institut de Bioenginyeria de Catalunya (IBEC) i del King\u2019s College de Londres han descobert que les c\u00e8l\u00b7lules no nom\u00e9s detecten les forces mec\u00e0niques, sin\u00f3 que tamb\u00e9 mesuren quant temps duren abans de respondre-hi.<\/strong> Els resultats, publicats en Nature Materials<\/em>, revelen un mecanisme temporal que permet a les c\u00e8l\u00b7lules ignorar el soroll mec\u00e0nic breu i reaccionar davant canvis sostinguts, un proc\u00e9s crucial en malalties com el c\u00e0ncer i la fibrosi.<\/strong><\/p>\n\n\n\n

\"\"
Fibroblast<\/figcaption><\/figure>\n\n\n\n

Un equip cient\u00edfic ha descobert com les c\u00e8l\u00b7lules decideixen quan respondre a les forces f\u00edsiques. La troballa t\u00e9 el potencial d’obrir noves vies per abordar malalties com el c\u00e0ncer i la fibrosi.<\/p>\n\n\n\n

L’estudi, liderat per investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC)<\/strong> i del King’s College de Londres<\/strong> i, revela que les c\u00e8l\u00b7lules del cos no nom\u00e9s detecten forces, sin\u00f3 que tamb\u00e9 mesuren quant duren aquestes forces abans de decidir actuar.<\/p>\n\n\n\n

En fer-ho, descriuen un mecanisme de sincronitzaci\u00f3 que permet a les c\u00e8l\u00b7lules ignorar est\u00edmuls mec\u00e0nics breus mentre reaccionen a canvis sostinguts, un proc\u00e9s crucial en la progressi\u00f3 de la malaltia.<\/p>\n\n\n\n

En el dia a dia, les c\u00e8l\u00b7lules estan exposades a una \u00e0mplia varietat de senyals mec\u00e0nics. Els teixits d’\u00f2rgans com els pulmons, el cor o la bufeta experimenten constantment forces r\u00e0pides i repetitives derivades de la respiraci\u00f3, els batecs o el buidatge de la bufeta, mentre que durant processos com la cicatritzaci\u00f3 de ferides o el creixement tumoral es produeixen canvis m\u00e9s lents i persistents.<\/p>\n\n\n\n

Les c\u00e8l\u00b7lules han d’interpretar cont\u00ednuament aquestes forces f\u00edsiques, juntament amb els senyals qu\u00edmics del seu entorn. Tot i que fa temps que es compr\u00e8n com responen les c\u00e8l\u00b7lules als senyals qu\u00edmics, se sabia molt menys sobre com processen els senyals mec\u00e0nics al llarg del temps.<\/p>\n\n\n\n

\n

Comprendre com les c\u00e8l\u00b7lules interpreten com aquests complexos senyals mec\u00e0nics estan influint en la progressi\u00f3 de la malaltia podria capacitar els investigadors per dissenyar millors ter\u00e0pies en el futur.<\/p>\n\n\n\n

Amy Beedle<\/p>\n<\/blockquote>\n\n\n\n

Ara, els investigadors creuen que les c\u00e8l\u00b7lules utilitzen una esp\u00e8cie de ‘filtre passabaix’ per descartar alteracions a curt termini, per\u00f2 responen a canvis persistents i a llarg termini.<\/p>\n\n\n\n

El professor Pere Roca-Cusachs<\/strong>, l\u00edder de l’estudi, investigador principal del grup de Mecanobiologia cel\u00b7lular i molecular<\/a> de l’IBEC i catedr\u00e0tic a la Facultat de Medicina i Ci\u00e8ncies de la Salut de la Universitat de Barcelona (UB), explica:<\/p>\n\n\n\n

“Imagina que condueixes per una autopista i sents un soroll fort al teu costat. Probablement reaccionar\u00e0s immediatament perqu\u00e8 podria ser perill\u00f3s. Per\u00f2 si sents un so petit i inusual del teu propi motor, pot ser que l’ignoris, llevat que persisteixi durant un temps. Les c\u00e8l\u00b7lules s’enfronten a un desafiament similar: han de decidir quins senyals importen i quan respondre-hi.”<\/p>\n\n\n\n

L’equip va descobrir que les c\u00e8l\u00b7lules depenen d’estructures anomenades adhesions fibril\u00b7lars, punts de contacte especialitzats que permeten a les c\u00e8l\u00b7lules agarrar-se f\u00edsicament al seu entorn i transmetre forces mec\u00e0niques al seu interior, per a aquest mecanisme.<\/p>\n\n\n\n

Aquestes estructures ajuden a ‘retenir’ el nucli cel\u00b7lular en un estat deformat, fins i tot despr\u00e9s que la for\u00e7a desaparegui, cosa que permet que el senyal persisteixi durant aproximadament una hora, mantinguda per una xarxa de fibres anomenada vimentina per mantenir l’efecte al llarg del temps. Quan aquest sistema s’interromp, les c\u00e8l\u00b7lules perden la capacitat de “retenir” senyals mec\u00e0nics i responen molt m\u00e9s r\u00e0pid, per\u00f2 de forma menys selectiva.<\/p>\n\n\n\n

En efecte, aix\u00f2 crea un filtre biol\u00f2gic. S’ignoren forces breus, per\u00f2 les sostingudes desencadenen una resposta. Molts processos importants, inclosa l’activitat de la prote\u00efna YAP associada al c\u00e0ncer, depenen d’aquests temps.<\/p>\n\n\n\n

La Dra. Amy Beedle<\/strong>, professora de F\u00edsica Biol\u00f2gica a King’s i primera autora de l’estudi, diu: “Aquest treball t\u00e9 enormes implicacions no nom\u00e9s pel que fa a com funcionen les c\u00e8l\u00b7lules i els teixits, sin\u00f3 tamb\u00e9 sobre aquest element temporal, que hem estat dels primers a examinar. \u00c9s un treball fonamental per al futur del tractament.<\/p>\n\n\n\n

“Moltes malalties, incloent-hi el c\u00e0ncer i la fibrosi, impliquen canvis a llarg termini en la rigidesa tissular i en les forces mec\u00e0niques. Comprendre com les c\u00e8l\u00b7lules interpreten com aquests complexos senyals mec\u00e0nics estan influint en la progressi\u00f3 de la malaltia podria capacitar els investigadors per dissenyar millors ter\u00e0pies en el futur.”<\/p>\n\n\n\n

Les troballes tamb\u00e9 mostren que aquest mecanisme ajuda a protegir el nucli cel\u00b7lular del dany sota estr\u00e8s f\u00edsic.<\/p>\n\n\n\n

L’equip ara pret\u00e9n explorar m\u00e9s a fons com funciona aquest mecanisme de sincronitzaci\u00f3 en teixits complexos i contextos de malaltia, on els canvis mec\u00e0nics s\u00f3n una part clau de la progressi\u00f3 de la malaltia.<\/p>\n\n\n\n

\n\n\n\n

Article de refer\u00e8ncia<\/strong><\/p>\n\n\n\n

Amy E. M. Beedle, Vivek Sharma, Jorge Oliver-De La Cruz, Anuja Jaganathan, Aina Albajar-Sigal\u00e9s 1, F. Max Yavitt, Kaustav Bera, Ion Andreu, Ignasi Granero-Moya, Dobryna Zalvidea, Zanetta Kechagia, Gerhard Wiche, Xavier Trepat, Johanna Ivaska, Kristi S. Anseth, Vivek B. Shenoy & Pere Roca-Cusachs. Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton. <\/strong>Nature Materials<\/em> (2026). DOI: https:\/\/doi.org\/10.1038\/s41563-026-02590-x<\/a> <\/p>\n\n\n\n

\n\n\n\n
\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Cient\u00edfics de l’Institut de Bioenginyeria de Catalunya (IBEC) i del King\u2019s College de Londres han descobert que les c\u00e8l\u00b7lules no nom\u00e9s detecten les forces mec\u00e0niques, sin\u00f3 que tamb\u00e9 mesuren quant temps duren abans de respondre-hi. Els resultats, publicats en Nature Materials, revelen un mecanisme temporal que permet a les c\u00e8l\u00b7lules ignorar el soroll mec\u00e0nic breu i reaccionar davant canvis sostinguts, un proc\u00e9s crucial en malalties com el c\u00e0ncer i la fibrosi.<\/p>\n","protected":false},"author":37,"featured_media":133366,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1812,1134],"post_formats":[],"class_list":["post-133371","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-cellular-and-molecular-mechanobiology-ca","tag-pere-roca-cusachs-ca"],"yoast_head":"\nLa forma en qu\u00e8 les c\u00e8l\u00b7lules decideixen quan reaccionar podria influir en futurs tractaments per al c\u00e0ncer i la fibrosi - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/la-forma-en-que-les-cel\u00b7lules-decideixen-quan-reaccionar-podria-influir-en-futurs-tractaments-per-al-cancer-i-la-fibrosi\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La forma en qu\u00e8 les c\u00e8l\u00b7lules decideixen quan reaccionar podria influir en futurs tractaments per al c\u00e0ncer i la fibrosi - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Cient\u00edfics de l'Institut de Bioenginyeria de Catalunya (IBEC) i del King\u2019s College de Londres han descobert que les c\u00e8l\u00b7lules no nom\u00e9s detecten les forces mec\u00e0niques, sin\u00f3 que tamb\u00e9 mesuren quant temps duren abans de respondre-hi. 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