{"id":133539,"date":"2026-05-07T09:00:00","date_gmt":"2026-05-07T07:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=133539"},"modified":"2026-05-06T16:32:40","modified_gmt":"2026-05-06T14:32:40","slug":"patients-with-duchenne-are-driving-the-development-of-a-heart-on-a-chip-to-halt-the-cardiac-damage-caused-by-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/together-with-patients-with-duchenne-ibec-is-developing-a-heart-on-a-chip-to-halt-the-cardiac-damage-caused-by-the-condition","title":{"rendered":"L’IBEC, juntament amb pacients amb Duchenne, impulsa un ‘cor en un xip’ per frenar el dany card\u00edac de la distr\u00f2fia"},"content":{"rendered":"\n

Duchenne Parent Project Espanya ha invertit 247.000 \u20ac en el projecte BEAT, que es portar\u00e0 a terme des de l’Institut de Bioenginyeria de Catalunya (IBEC)<\/strong>. La cardiomiopatia \u00e9s la principal causa de mortalitat en els pacients amb Distr\u00f2fia Muscular de Duchenne (DMD).<\/strong> La distr\u00f2fia muscular de Duchenne afecta uns 1.100 espanyols.<\/strong><\/p>\n\n\n\n

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Juan Manuel Fern\u00e1ndez (esquerra) i Marisol Montolio (dreta).<\/figcaption><\/figure>\n\n\n\n

Duchenne Parent Project Espanya (DPPE)<\/strong> ha posat en marxa el Projecte BEAT, una investigaci\u00f3 orientada a un dels principals reptes en les distr\u00f2fies musculars de Duchenne i Becker<\/strong>: el dany progressiu del cor, ja que la cardiomiopatia \u00e9s la principal causa de mortalitat en els pacients amb DMD.<\/p>\n\n\n\n

\n

Estudiarem la patologia card\u00edaca en ratolins i pacients per construir un model card\u00edac 3D que imiti la malaltia humana. La plataforma de cor en un xip inclou sensors que rastregen el dany i la fibrosi en temps real, ajudant-nos a trobar i provar tractaments prometedors.<\/em> <\/em><\/p>\n\n\n\n

Juan Manuel Fern\u00e1ndez<\/p>\n<\/blockquote>\n\n\n\n

Aquest projecte, en el qual DPPE ha invertit 247.000 euros, desenvolupar\u00e0 una plataforma de ‘cor en un xip’<\/strong> (heart-on-a-xip). “Gr\u00e0cies a aquest avan\u00e7, estalviarem un temps vital en reduir el nombre d’animals i ens permetr\u00e0 reproduir en laboratori teixit card\u00edac hum\u00e0 afectat per la malaltia, monitorar la fibrosi (teixit cicatricial) en temps real i provar candidats”<\/em>, explica la Dra. Marisol Montolio<\/strong>, directora del Departament de Recerca de Duchenne Parent Project Espanya.<\/p>\n\n\n\n

La falta de distrofina, prote\u00efna absent o defectuosa en aquestes malalties, no nom\u00e9s afecta el m\u00fascul esquel\u00e8tic. Tamb\u00e9 compromet el m\u00fascul card\u00edac, afavorint l’aparici\u00f3 de fibrosi, un proc\u00e9s pel qual el teixit sa \u00e9s substitu\u00eft per teixit cicatricial, la qual cosa debilita progressivament la funci\u00f3 del cor. Aix\u00f2 provoca la mort cel\u00b7lular i el seu reempla\u00e7ament per teixit fibr\u00f2tic.<\/p>\n\n\n\n

El projecte ser\u00e0 liderat des de l‘Institut de Bioenginyeria de Catalunya (IBEC)<\/strong> pel Dr. Juan Manuel Fern\u00e1ndez<\/strong>, investigador s\u00e8nior del grup de Biosensors per a Bioenginyeria<\/a> a l’IBEC i investigador principal de BEAT. A m\u00e9s, comptar\u00e0 amb la col\u00b7laboraci\u00f3 del Registre de Pacients de Duchenne Parent Project Espanya, la Universitat de Ja\u00e9n, l’Hospital Sant Joan de D\u00e9u i la Universitat de Newcastle.<\/p>\n\n\n\n

“Estudiarem la patologia card\u00edaca en ratolins i pacients per construir un model card\u00edac 3D que imiti la malaltia humana. La plataforma de cor en un xip inclou sensors que rastregen el dany i la fibrosi en temps real, ajudant-nos a trobar i provar tractaments prometedors. Aquesta plataforma tamb\u00e9 es podria fer servir per estudiar altres malalties card\u00edaques, accelerant el descobriment de f\u00e0rmacs”<\/em>, precisa el Dr. Fern\u00e1ndez.<\/p>\n\n\n\n

Recerca impulsada per les fam\u00edlies<\/strong><\/strong><\/h4>\n\n\n\n

Per a Duchenne Parent Project Espanya, BEAT representa una aposta per una investigaci\u00f3 centrada en les necessitats reals dels pacients i les seves fam\u00edlies. L’afectaci\u00f3 card\u00edaca \u00e9s una de les principals preocupacions en l’evoluci\u00f3 de la malaltia, per la qual cosa avan\u00e7ar en eines que permetin comprendre-la millor i accelerar l’avaluaci\u00f3 de tractaments suposa una prioritat. “BEAT \u00e9s el pols de la nostra lluita. Significa batec, per\u00f2 tamb\u00e9 significa v\u00e8ncer. I aix\u00f2 \u00e9s el que vam fer amb la cardiomiopatia associada a les distr\u00f2fies musculars de Duchenne i Becker”<\/em>, afirma Silvia \u00c1vila<\/strong>, presidenta de Duchenne Parent Project Espanya.<\/p>\n\n\n\n

El projecte tamb\u00e9 contempla la participaci\u00f3 de les fam\u00edlies a trav\u00e9s d’un comit\u00e8 assessor, amb l’objectiu de mantenir una recerca alineada amb les prioritats de la comunitat Duchenne i Becker. Amb aquesta iniciativa, Duchenne Parent Project Espanya refor\u00e7a el seu comprom\u00eds amb la innovaci\u00f3 biom\u00e8dica, l’acc\u00e9s a noves solucions terap\u00e8utiques i la millora de la qualitat de vida de les persones afectades per distr\u00f2fies musculars de Duchenne i Becker. A m\u00e9s, per poder augmentar els fons destinats a aquesta investigaci\u00f3, han posat en marxa un proc\u00e9s de crowdfunding<\/em> a trav\u00e9s de la plataforma iHelp<\/a>.<\/p>\n\n\n\n

La Distr\u00f2fia Muscular de Duchenne (DMD) \u00e9s una malaltia gen\u00e8tica, degenerativa i sense cura, que afecta en Espanya prop de 1.100 persones. Es caracteritza per l’abs\u00e8ncia de distrofina, una prote\u00efna essencial per a l’estabilitat i el funcionament del m\u00fascul. Aquesta mancan\u00e7a genera un cicle continu de dany i inflamaci\u00f3 que accelera el deteriorament muscular. La seva evoluci\u00f3 provoca una p\u00e8rdua progressiva de mobilitat i la necessitat de suport vital i atenci\u00f3 domicili\u00e0ria 24 hores, generalment proporcionada per les seves fam\u00edlies des d’edats primerenques.<\/p>\n\n\n\n

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Duchenne Parent Project Espanya ha invertit 247.000 \u20ac en el projecte BEAT, que es portar\u00e0 a terme des de l’Institut de Bioenginyeria de Catalunya (IBEC). La cardiomiopatia \u00e9s la principal causa de mortalitat en els pacients amb Distr\u00f2fia Muscular de Duchenne (DMD). La distr\u00f2fia muscular de Duchenne afecta uns 1.100 espanyols.<\/p>\n","protected":false},"author":37,"featured_media":133526,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1999,1131,1852],"post_formats":[],"class_list":["post-133539","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-biosensors-for-bioengineering-ca","tag-javier-ramon-ca","tag-malalties-neuromusculars"],"yoast_head":"\nL'IBEC, juntament amb pacients amb Duchenne, impulsa un 'cor en un xip' per frenar el dany card\u00edac de la distr\u00f2fia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/together-with-patients-with-duchenne-ibec-is-developing-a-heart-on-a-chip-to-halt-the-cardiac-damage-caused-by-the-condition\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'IBEC, juntament amb pacients amb Duchenne, impulsa un 'cor en un xip' per frenar el dany card\u00edac de la distr\u00f2fia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Duchenne Parent Project Espanya ha invertit 247.000 \u20ac en el projecte BEAT, que es portar\u00e0 a terme des de l'Institut de Bioenginyeria de Catalunya (IBEC). 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