{"id":136518,"date":"2026-10-14T15:55:23","date_gmt":"2026-10-14T13:55:23","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/lab-designed-molecule-reduces-amyloid-beta-the-protein-linked-to-alzheimers-disease-in-mice\/"},"modified":"2026-10-14T17:00:01","modified_gmt":"2026-10-14T15:00:01","slug":"una-molecula-dissenyada-al-laboratori-redueix-la-beta-amiloide-la-proteina-associada-a-lalzheimer-en-ratolins","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-molecula-dissenyada-al-laboratori-redueix-la-beta-amiloide-la-proteina-associada-a-lalzheimer-en-ratolins\/","title":{"rendered":"Una mol\u00e8cula dissenyada al laboratori redueix la beta-amiloide, la prote\u00efna associada a l\u2019alzheimer, en ratolins"},"content":{"rendered":"\n

Un estudi liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC) identifica una mol\u00e8cula, P33, que modula parcialment l\u2019enzim que inicia la formaci\u00f3 de beta-amiloide. Els resultats, obtinguts en cultius cel\u00b7lulars i en ratolins, obren una nova via de recerca qu\u00edmica sobre la malaltia. <\/strong><\/p>\n\n\n\n

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D’esquerra a dreta: Dayaneth J\u00e1come, Jos\u00e9 A. Del R\u00edo i Rosalina Gav\u00edn.<\/figcaption><\/figure>\n\n\n\n

Un equip de recerca liderat pel grup de Neurobiotecnologia Molecular i Cel\u00b7lular <\/a>de l\u2019Institut de Bioenginyeria de Catalunya (IBEC)<\/strong>, en col\u00b7laboraci\u00f3 amb el laboratori de M\u00edriam Royo de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC)<\/strong>, la Universitat de Barcelona (UB)<\/strong> i l\u2019Institut de Recerca Biom\u00e8dica de Barcelona (IRB Barcelona)<\/strong>, ha identificat un p\u00e8ptid sint\u00e8tic que redueix la producci\u00f3 de beta-amiloide (A\u03b2). Aquesta prote\u00efna s\u2019acumula al cervell en la malaltia d\u2019Alzheimer. El treball, publicat a la revista Bioorganic Chemistry<\/a>, s\u2019ha dut a terme en neurones en cultiu (in vitro<\/em>) i en un model de ratol\u00ed de la malaltia (in vivo). <\/p>\n\n\n\n

En la producci\u00f3 d\u2019A\u03b2 hi interv\u00e9 un enzim, BACE1. Els enzims s\u00f3n prote\u00efnes que faciliten reaccions qu\u00edmiques a les c\u00e8l\u00b7lules; en aquest cas, BACE1 actua com unes \u00abtisores\u00bb que tallen una altra prote\u00efna i donen lloc a la beta-amiloide. Els f\u00e0rmacs dissenyats per bloquejar-lo completament no han superat els assajos cl\u00ednics, en part pels efectes secundaris de bloquejar tamb\u00e9 altres funcions necess\u00e0ries de l\u2019enzim. L\u2019equip ha provat una altra estrat\u00e8gia: ha dissenyat uns p\u00e8ptids, petites cadenes com les que formen les prote\u00efnes, i els ha modificat qu\u00edmicament perqu\u00e8 l\u2019organisme no els destrueixi r\u00e0pidament i perqu\u00e8 puguin entrar a les c\u00e8l\u00b7lules, on es produeix la beta-amiloide. <\/p>\n\n\n\n

\u201cVam analitzar una biblioteca de 50 d\u2019aquestes mol\u00e8cules en neurones en cultiu. P33 va destacar perqu\u00e8 redu\u00efa clarament la beta-amiloide sense danyar les c\u00e8l\u00b7lules i, a m\u00e9s, frenava de manera selectiva l\u2019activitat de BACE1\u00bb, <\/em>explica Dayaneth J\u00e1come<\/strong>, primera autora de l\u2019estudi i investigadora de l\u2019IBEC.<\/p>\n\n\n\n

\n

Els nostres resultats mostren que no cal bloquejar completament BACE1 per reduir la producci\u00f3 de beta-amiloide, almenys en models de laboratori. Aquests p\u00e8ptids ens ofereixen una plataforma qu\u00edmica vers\u00e0til per continuar investigant aquesta via. <\/em>.<\/p>\n\n\n\n

Jos\u00e9 A. Del R\u00edo<\/p>\n<\/blockquote>\n\n\n\n

En neurones de ratol\u00ed en cultiu, P33 va reduir l\u2019alliberament d\u2019A\u03b2 a menys de la meitat sense danyar les c\u00e8l\u00b7lules. Tamb\u00e9 va disminuir m\u00e9s d\u2019un 50% l\u2019activitat associada a BACE1, sense afectar significativament un enzim molt similar, BACE2. En ratolins modificats gen\u00e8ticament per desenvolupar plaques d\u2019amiloide, l\u2019administraci\u00f3 de P33 durant vuit setmanes va reduir un 35,6% els nivells d\u2019A\u03b2 cerebral i la superf\u00edcie ocupada per plaques a l\u2019escor\u00e7a i l\u2019hipocamp. No es van detectar danys en altres \u00f2rgans ni canvis en els marcadors d\u2019inflamaci\u00f3 analitzats. <\/p>\n\n\n\n

\u201cEls nostres resultats mostren que no cal bloquejar completament BACE1 per reduir la producci\u00f3 de beta-amiloide, almenys en models de laboratori. Aquests p\u00e8ptids ens ofereixen una plataforma qu\u00edmica vers\u00e0til per continuar investigant aquesta via. <\/em>\u00bb, explica Jos\u00e9 A. Del R\u00edo<\/strong>, investigador principal a l\u2019IBEC, catedr\u00e0tic de la Facultat de Biologia de la Universitat de Barcelona (UB), membre de l\u2019Institut de Neuroci\u00e8ncies de la Universitat de Barcelona (UBneuro) i del CIBERNED, i col\u00edder de l\u2019estudi.<\/p>\n\n\n\n

\u201cAquests primers resultats en ratolins obren diverses l\u00ednies de treball. Ara volem ampliar els estudis amb un nombre m\u00e9s gran d\u2019animals, mesurar quant P33 arriba al cervell i confirmar amb precisi\u00f3 com actua sobre BACE1 <\/em>,\u201d assenyala Rosalina Gav\u00edn<\/strong>, col\u00edder de l\u2019estudi, investigadora s\u00e8nior de l\u2019IBEC, professora agregada de la UB i membre de l\u2019UBneuro i del CIBERNED. L\u2019equip tamb\u00e9 vol comprovar si la tend\u00e8ncia a una millor mem\u00f2ria que van mostrar els ratolins tractats es confirma en estudis m\u00e9s amplis. <\/p>\n\n\n\n

\n\n\n\n

Article de refer\u00e8ncia<\/strong><\/p>\n\n\n\n

Dayaneth J\u00e1come, Marina P\u00e9rez-Palau, In\u00e9s Mart\u00ednez-Soria, Laia Lid\u00f3n, Cristina Vergara, Daniel Carbajo, Ximena Pulido, Macarena S\u00e1nchez-Navarro, Ernest Giralt, Fernando Albericio, Miriam Royo, Rosalina Gav\u00edn, Jos\u00e9 Antonio Del R\u00edo. cis<\/em>-\u03b3-Amino-L-proline peptides as chemical probes of amyloidogenic processing in neurons and APP\/PS1 mice.<\/strong> Bioorganic Chemistry<\/em> (2026). DOI: https:\/\/doi.org\/10.1016\/j.bioorg.2026.110386<\/a> <\/p>\n\n\n\n

\n\n\n\n
\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Un estudi liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC) identifica una mol\u00e8cula, P33, que modula parcialment l\u2019enzim que inicia la formaci\u00f3 de beta-amiloide. Els resultats, obtinguts en cultius cel\u00b7lulars i en ratolins, obren una nova via de recerca qu\u00edmica sobre la malaltia. <\/p>\n","protected":false},"author":37,"featured_media":136515,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1627,1132,1581],"post_formats":[],"class_list":["post-136518","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-alzheimer-ca-2","tag-jose-antonio-del-rio-ca","tag-molecular-and-cellular-neurobiotechnology-group-ca"],"yoast_head":"\nUna mol\u00e8cula dissenyada al laboratori redueix la beta-amiloide, la prote\u00efna associada a l\u2019alzheimer, en ratolins - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-molecula-dissenyada-al-laboratori-redueix-la-beta-amiloide-la-proteina-associada-a-lalzheimer-en-ratolins\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una mol\u00e8cula dissenyada al laboratori redueix la beta-amiloide, la prote\u00efna associada a l\u2019alzheimer, en ratolins - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi liderat per l\u2019Institut de Bioenginyeria de Catalunya (IBEC) identifica una mol\u00e8cula, P33, que modula parcialment l\u2019enzim que inicia la formaci\u00f3 de beta-amiloide. 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