{"id":137398,"date":"2026-11-05T14:30:00","date_gmt":"2026-11-05T13:30:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=137398"},"modified":"2026-11-04T12:51:52","modified_gmt":"2026-11-04T11:51:52","slug":"la-marato-de-3cat-financa-dos-projectes-de-ibec-per-millorar-la-immunoterapia-en-tumors-solids","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/la-marato-de-3cat-financa-dos-projectes-de-ibec-per-millorar-la-immunoterapia-en-tumors-solids\/","title":{"rendered":"La Marat\u00f3 de 3Cat finan\u00e7a dos projectes de l\u2019IBEC per millorar la immunoter\u00e0pia en tumors s\u00f2lids"},"content":{"rendered":"\n

La Fundaci\u00f3 La Marat\u00f3 de 3Cat ha seleccionat dos projectes coordinats per investigadors de l\u2019IBEC, Xavier Rovira i Xavier Trepat, en la convocat\u00f2ria d\u2019ajuts a la recerca sobre c\u00e0ncer de l\u2019edici\u00f3 2025. Cada projecte rebr\u00e0 300.000 euros. Durant tres anys, tots dos estudiaran per qu\u00e8 les c\u00e8l\u00b7lules del sistema immunitari tenen dificultats per penetrar en els tumors s\u00f2lids, un dels principals obstacles de la immunoter\u00e0pia en c\u00e0ncers com el de mama o el colorectal.<\/strong><\/strong><\/p>\n\n\n\n

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Xavier Rovira Clav\u00e9 (esquerra) i Xavier Trepat (dreta).<\/figcaption><\/figure>\n\n\n\n
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La Marat\u00f3 de 3Cat 2025<\/a>, celebrada el 14 de desembre, es va dedicar al c\u00e0ncer i va tancar amb una recaptaci\u00f3 final de 14.425.548 euros. La Fundaci\u00f3 ha presentat avui, en un acte al plat\u00f3 1 de TV3, els 38 projectes seleccionats per rebre aquests fons. Es van presentar 201 propostes, que 169 experts internacionals van avaluar mitjan\u00e7ant un proc\u00e9s de revisi\u00f3 per experts gestionat per l\u2019Ag\u00e8ncia de Qualitat i Avaluaci\u00f3 Sanit\u00e0ries de Catalunya (AQuAS). Dos dels projectes seleccionats estan coordinats des de l\u2019IBEC.<\/p>\n\n\n\n

C\u00e8l\u00b7lules NK modificades per travessar les defenses del c\u00e0ncer de mama<\/strong><\/strong><\/h4>\n\n\n\n

El projecte iNKFILTRATE<\/strong> est\u00e0 coordinat per Xavier Rovira Clav\u00e9<\/strong>, l\u00edder del grup de Biotecnologia Espacial<\/a> de l\u2019IBEC, i es desenvolupa conjuntament amb el grup de Ter\u00e0pies Avan\u00e7ades Derivades d\u2019iPSC que dirigeix Bel\u00e9n \u00c1lvarez Palomo<\/strong> al Banc de Sang i Teixits (BST)<\/strong>. El projecte se centra en les c\u00e8l\u00b7lules natural killer<\/em> (NK), un tipus de c\u00e8l\u00b7lula immunit\u00e0ria capa\u00e7 de recon\u00e8ixer i eliminar c\u00e8l\u00b7lules tumorals.<\/p>\n\n\n\n

L\u2019equip obtindr\u00e0 aquestes c\u00e8l\u00b7lules a partir de c\u00e8l\u00b7lules mare pluripotents indu\u00efdes (iPSC). Es tracta d\u2019una font estandarditzada que, en el futur, podria permetre produir-les a gran escala i tenir-les disponibles per a qualsevol pacient. Les ter\u00e0pies CAR-T actuals, en canvi, es fabriquen de manera individualitzada a partir de les c\u00e8l\u00b7lules de cada persona.<\/p>\n\n\n\n

Per ajudar-les a trobar el seu objectiu, els investigadors modificaran gen\u00e8ticament aquestes c\u00e8l\u00b7lules perqu\u00e8 reconeguin p95HER2, una variant de la prote\u00efna HER2 que apareix en una part dels c\u00e0ncers de mama HER2 positius i que no es troba en els teixits sans. A m\u00e9s, les dotaran d\u2019eines per obrir-se pas a trav\u00e9s de l\u2019estroma, la capa de teixit dens que protegeix el tumor. Tamb\u00e9 les prepararan per continuar actives en un entorn que tendeix a desactivar les defenses del cos.<\/p>\n\n\n\n

Els investigadors avaluaran aquestes variants en models tridimensionals in vitro<\/em> de c\u00e0ncer de mama i en models animals. Per analitzar-les utilitzaran t\u00e8cniques d\u2019imatge espacial d\u2019alta resoluci\u00f3, com la imatge multiplexada per feix d\u2019ions (MIBI), que permeten cartografiar c\u00e8l\u00b7lula a c\u00e8l\u00b7lula on se situen les c\u00e8l\u00b7lules NK dins del tumor. Aix\u00ed podran identificar quines caracter\u00edstiques de l\u2019organitzaci\u00f3 tumoral s\u2019associen a una resposta efica\u00e7. L\u2019objectiu \u00e9s trobar possibles biomarcadors predictius i establir criteris de disseny per a futures immunoter\u00e0pies cel\u00b7lulars contra tumors s\u00f2lids.<\/p>\n\n\n\n

La mec\u00e0nica del tumor com a barrera per a les c\u00e8l\u00b7lules immunit\u00e0ries<\/strong><\/strong><\/h4>\n\n\n\n

El segon projecte est\u00e0 coordinat per Xavier Trepat<\/strong>, l\u00edder del grup de Din\u00e0mica Integrativa de C\u00e8l\u00b7lules i Teixits<\/a> de l\u2019IBEC, en col\u00b7laboraci\u00f3 amb el grup de Luis Francisco Lorenzo-Mart\u00edn<\/strong> al Centre d\u2019Investigaci\u00f3 del C\u00e0ncer (CIC)<\/strong> de Salamanca. Fins ara, la recerca sobre com els tumors colorectals aconsegueixen escapar del sistema immunitari s\u2019ha centrat sobretot en factors bioqu\u00edmics i gen\u00e8tics. Aquest projecte parteix d\u2019una hip\u00f2tesi diferent: que les propietats mec\u00e0niques del tumor i les forces que s\u2019hi generen dificulten que els limf\u00f2cits T hi entrin i eliminin les c\u00e8l\u00b7lules canceroses.<\/p>\n\n\n\n

Per posar-la a prova, els equips desenvoluparan \u00abminic\u00f2lons\u00bb, uns sistemes d\u2019\u00f2rgan en un xip (organ-on-a-chip<\/em>). Aquests sistemes combinen organoides tumorals, alguns derivats de pacients, amb fibroblasts associats al c\u00e0ncer, c\u00e8l\u00b7lules endotelials i c\u00e8l\u00b7lules immunit\u00e0ries, organitzats de manera que reprodueixin l\u2019arquitectura del teixit.<\/p>\n\n\n\n

Els investigadors mesuraran la rigidesa i les forces cel\u00b7lulars d\u2019aquest entorn i les modificaran amb eines com l\u2019optogen\u00e8tica o f\u00e0rmacs. D\u2019aquesta manera podran estudiar com l\u2019entorn f\u00edsic del tumor condiciona la migraci\u00f3 i la capacitat citot\u00f2xica de les c\u00e8l\u00b7lules T. Els resultats podrien ajudar a identificar mecanismes f\u00edsics que impedeixen l\u2019entrada de les c\u00e8l\u00b7lules immunit\u00e0ries al tumor i sobre els quals es pugui actuar per millorar l\u2019efic\u00e0cia de la immunoter\u00e0pia, i aportar noves eines per avaluar-la.<\/p>\n\n\n\n

Tots dos projectes se centren en la recerca b\u00e0sica i precl\u00ednica, una etapa clau per generar el coneixement i les eines que han de fer possible, en el futur, noves estrat\u00e8gies d\u2019immunoter\u00e0pia per a tumors s\u00f2lids. L\u2019IBEC agraeix a la Fundaci\u00f3 La Marat\u00f3 de 3Cat i a totes les persones que hi van contribuir, el seu suport, que fa possible una recerca impulsada pel comprom\u00eds de la ciutadania en la lluita contra el c\u00e0ncer.<\/p>\n\n\n\n

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<\/p>\n","protected":false},"excerpt":{"rendered":"

La Fundaci\u00f3 La Marat\u00f3 de 3Cat ha seleccionat dos projectes coordinats per investigadors de l\u2019IBEC, Xavier Rovira i Xavier Trepat, en la convocat\u00f2ria d\u2019ajuts a la recerca sobre c\u00e0ncer de l\u2019edici\u00f3 2025. Cada projecte rebr\u00e0 300.000 euros. Durant tres anys, tots dos estudiaran per qu\u00e8 les c\u00e8l\u00b7lules del sistema immunitari tenen dificultats per penetrar en els tumors s\u00f2lids, un dels principals obstacles de la immunoter\u00e0pia en c\u00e0ncers com el de mama o el colorectal.<\/p>\n","protected":false},"author":37,"featured_media":137395,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1774,2187,1817,2095,2082,1143],"post_formats":[],"class_list":["post-137398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-cancer-ca","tag-integrative-cell-an-tissue-dynamics","tag-premi","tag-spatial-biotechnology-ca","tag-xavier-rovira-ca","tag-xavier-trepat-ca"],"yoast_head":"\nLa Marat\u00f3 de 3Cat finan\u00e7a dos projectes de l\u2019IBEC per millorar la immunoter\u00e0pia en tumors s\u00f2lids - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/la-marato-de-3cat-funds-two-ibec-projects-to-improve-immunotherapy-for-solid-tumours\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La Marat\u00f3 de 3Cat finan\u00e7a dos projectes de l\u2019IBEC per millorar la immunoter\u00e0pia en tumors s\u00f2lids - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La Fundaci\u00f3 La Marat\u00f3 de 3Cat ha seleccionat dos projectes coordinats per investigadors de l\u2019IBEC, Xavier Rovira i Xavier Trepat, en la convocat\u00f2ria d\u2019ajuts a la recerca sobre c\u00e0ncer de l\u2019edici\u00f3 2025. 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