{"id":16097,"date":"2015-03-18T16:58:56","date_gmt":"2015-03-18T16:58:56","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=16097"},"modified":"2015-10-20T13:36:09","modified_gmt":"2015-10-20T13:36:09","slug":"descobreixen-una-molecula-que-inhibeix-la-replicacio-de-ladn-dels-bacteriss","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/descobreixen-una-molecula-que-inhibeix-la-replicacio-de-ladn-dels-bacteriss\/","title":{"rendered":"Descobreixen una mol\u00e8cula que inhibeix la replicaci\u00f3 de l’ADN dels bacteriss"},"content":{"rendered":"
Imagen: Desensamblaje del biofilm existente de\u00a0P. <\/i>aeruginosa<\/i>\u00a0a\u00f1adiendo\u00a0M-HA.<\/h6>\n

En un article publicat ahir a la revista PlosOne, amb el resultat d’un estudi dut a terme per investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), de l\u2019Institut de Recerca de l\u2019Hospital de la Vall d’Hebron (VHIR) i del grup de recerca de Micobacteris del Departament de Gen\u00e8tica i Microbiologia de la Universitat Aut\u00f2noma de Barcelona (UAB), es descriu una nova mol\u00e8cula que t\u00e9 potencial per ser un nou concepte d’agent antibacteri\u00e0, ja que actua espec\u00edficament en un enzim bacteri\u00e0 que inhibeix la reproducci\u00f3 de la mateixa.<\/p>\n

Aquesta troballa, \u00e9s avui en dia de rellevant import\u00e0ncia, ja que segons un estudi realitzat per l’Ag\u00e8ncia Europea de Medicaments, a m\u00e9s d’una creixent resist\u00e8ncia als agents existents, hi ha falta de nous antibi\u00f2tics en desenvolupament. D’aqu\u00ed a pocs anys, llevat que es prenguin immediatament mesures coordinades globals, podr\u00edem trobar-nos amb una situaci\u00f3 m\u00e9s alarmant encara. La projecci\u00f3 per al 2050 \u00e9s de 10 milions de morts anuals (al mon), superant l’actual taxa anual de mortalitat per c\u00e0ncer.<\/p>\n

“La infecci\u00f3 bacteriana es produeix quan aquestes es multipliquen a l’interior del cos hum\u00e0 replicant el seu ADN”, diu Eduard Torrents, investigador principal del grup de “Infeccions bacterianes: ter\u00e0pies antimicrobianes” al IBEC. “La r\u00e8plica de l’ADN bacteri\u00e0 es produeix gr\u00e0cies a un enzim clau que permet que aix\u00f2 passi, si dirigim el tractament a aquest enzim clau podem inhibir el creixement de diversos tipus de bacteris indesitjables causants de malalties”.<\/p>\n

\"eduarddr\"<\/p>\n

La mol\u00e8cula, coneguda com M-HA, funciona inhibint l’enzim essencial per a la replicaci\u00f3 i la reparaci\u00f3 de l’ADN dels bacteris, la ribonucle\u00f3tido reductasa (RNR) i, a m\u00e9s, mostra una baixa toxicitat en c\u00e8l\u00b7lules eucariotes (com les humanes), el que anuncia una gran millora pel que fa als f\u00e0rmacs existents inhibidors de RNR, que s\u00f3n els que s’utilitzen principalment contra el c\u00e0ncer o els virus que s\u00f3n massa t\u00f2xics per a ser utilitzats com antibacterians.<\/p>\n

“\u00c9s crucial trobar nous agents antibacterians com aquest, que funcionin d’una manera diferent dels actuals, perqu\u00e8 puguin reempla\u00e7ar als antibi\u00f2tics existents que s’estan veient inutilitzats a causa de la resist\u00e8ncia bacteriana”, diu Eduard Torrents. “Aquests nous candidats a f\u00e0rmacs tamb\u00e9 han de treballar de manera que no permetin que els bacteris acumulin tal nivell de resist\u00e8ncia.”<\/p>\n

Els investigadors van provar la M-HA i va revelar la seva capacitat per inhibir el creixement de pat\u00f2gens bacterians com ara Pseudomonas<\/em> o Mycobacterium<\/em>, incl\u00f2s Staphylococcus aureus<\/em>, Streptococcus sanguinis<\/em>, Streptococcus mutans<\/em>, P. aeruginosa<\/em> i Burkholderia cenocepacia<\/em>.<\/p>\n

“Durant 2014, l’OMS, el primer ministre del Regne Unit David Cameron, el president Obama i el F\u00f2rum Econ\u00f2mic Mundial van fer de la Resist\u00e8ncia als Antibi\u00f2tics el focus de diferents informes i accions que van comportar gran visibilitat. Tots ells van recon\u00e8ixer el car\u00e0cter global de la crisi, van iniciar accions locals i van demanar actuacions de lideratge i coordinaci\u00f3 internacional “, diu el Dr. Joan Gavald\u00e0 del Grup de recerca en Malalties Infeccioses del VHIR. “Es reconeix que hi ha una necessitat immediata de finan\u00e7ament per a la investigaci\u00f3 per al desenvolupament de nous antibi\u00f2tics per al tractament de les infeccions multiresistents i per preservar l’efic\u00e0cia dels antibi\u00f2tics. Es necessiten amb urg\u00e8ncia nous antibi\u00f2tics amb nous mecanismes d’acci\u00f3 com la M-HA, que actu\u00efn contra els bacteris per mantenir la medicina moderna tal com la coneixem avui en dia”.<\/p>\n

— Article de refer\u00e8ncia:<\/em> \u00a0<\/strong>Esther Juli\u00e1n, Aida Baelo, Joan Gavald\u00e0 & Eduard Torrents (2015). Methyl-hydroxylamine as an efficacious antibacterial agent that targets the ribonucleotide reductase enzyme.<\/a>\u00a0PLoS ONE<\/em> 10(3): e0122049<\/p>\n

— IBEC als Mitjans:<\/strong>\u00a0S’ha parlat del tema a la\u00a0Gaceta M\u00e9dica<\/a>\u00a0el 23 de Mar\u00e7\u00a0i al\u00a0Diario de Terrassa<\/a>\u00a0el 7 d’Abril.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"torrentsL’augment de la prevalen\u00e7a de bacteris resistents als antibi\u00f2tics actuals \u00e9s una greu amena\u00e7a per a la salut p\u00fablica. En un treball d’equip entre investigadors a Barcelona s’ha identificat una mol\u00e8cula potencial per ser un nou concepte d’agent antibacteri\u00e0<\/h3>\n

Els antibi\u00f2tics s\u00f3n essencials en tots els sistemes de salut. Els \u00e8xits de la medicina moderna que avui ens semblen tan habituals; com l’augment de la seguretat en els parts, el tractament dels nadons prematurs, les cirurgies, el tractament de la pneum\u00f2nia, els trasplantaments d’\u00f2rgans i la quimioter\u00e0pia contra el c\u00e0ncer, no serien possibles sense els antibi\u00f2tics. La resist\u00e8ncia als antibi\u00f2tics \u00e9s un problema de salut global. Anualment moren 50000 pacients per infeccions per bacteris multiresistents (a Europa i USA), amb un cost de 1,5 bilions d’EUR i 35 bilions de $USA.<\/p>\n","protected":false},"author":4,"featured_media":15592,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-16097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nDescobreixen una mol\u00e8cula que inhibeix la replicaci\u00f3 de l'ADN dels bacteriss - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/descobreixen-una-molecula-que-inhibeix-la-replicacio-de-ladn-dels-bacteriss\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descobreixen una mol\u00e8cula que inhibeix la replicaci\u00f3 de l'ADN dels bacteriss - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L'augment de la prevalen\u00e7a de bacteris resistents als antibi\u00f2tics actuals \u00e9s una greu amena\u00e7a per a la salut p\u00fablica. 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