{"id":16477,"date":"2015-04-28T14:22:49","date_gmt":"2015-04-28T14:22:49","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=16477"},"modified":"2015-10-20T14:13:23","modified_gmt":"2015-10-20T14:13:23","slug":"dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\/","title":{"rendered":"Dos grups del IBEC uneixen forces per combatre les infeccions bacterianes cr\u00f2niques"},"content":{"rendered":"<p>Les infeccions causades per aquestes bact\u00e8ries s\u00f3n una gran amena\u00e7a per als pacients hospitalitzats, en implants m\u00e8dics i en les ferides cr\u00f2niques, a m\u00e9s de ser la causa principal de la malaltia pulmonar obstructiva cr\u00f2nica (EPOC) i la fibrosi qu\u00edstica.<\/p>\n<h6 class=\"caption\" style=\"float: left; width: 310px; padding: 0px 20px 0px 0px;\">An\u00e0lisi de superf\u00edcie de Pseudomonas aeruginosa salvatge del tipus PAO1 de quatre dies de vida en biofilm. Imatges pr\u00f2ximes del biofilm fetes amb microscopi confocal d&#8217;escombrat l\u00e0ser. Es mostra una representaci\u00f3 de les nanopart\u00edcules utilitzades en aquest estudi.<\/h6>\n<p>&#8220;Hi ha una \u00a0necessitat urgent de nous enfocs terap\u00e8utics per a les infeccions causades per bact\u00e8ries formadores de biofilm, ja que els antibi\u00f2tics actuals no aconsegueixen eliminar aquesta mena de bact\u00e8ries&#8221;, explica Eduard Torrents, responsable del grup de Infeccions bacterianes: ter\u00e0pies antimicrobianes. &#8220;La nostra estrat\u00e8gia amb nanopart\u00edcules constitueix un canvi de paradigma en el tractament dels biofilms, ja que a m\u00e9s de l&#8217;alliberaci\u00f3 de ciproflozacina d&#8217;una manera controlada, s\u00f3n capa\u00e7os d&#8217;atacar i desmuntar el biofilm degradant l&#8217;ADN extracel\u00b7lular que estabilitza la seva matriu&#8221;<\/p>\n<p>A l&#8217;estudi en el que estaven involucrats el grup de biomaterials per a ter\u00e0pies regeneratives i el grup de Infeccions bacterianes; ter\u00e0pies antimicrobianes del IBEC juntament amb la Universitat Aut\u00f2noma de Barcelona i l&#8217;Institut de Recerca Vall d&#8217;Hebr\u00f3n, es van fabricar nanopart\u00edcules d&#8217;\u00e0cid polil\u00e0ctic-co-glic\u00f2lic (PLGA) carregades amb l&#8217;antibi\u00f2tic ciproflozacina que s&#8217;ha funcionalitzat amb la DNAasa I, una nucleasa que digereix l&#8217;ADN. Tamb\u00e9 es va analitzar l&#8217;activitat antibiopel\u00b7l\u00edcula contra els biofilms de P. aeruginosa, una bact\u00e8ria que sovint \u00e9s la causa de problemes pulmonars en pacients amb fibrosi qu\u00edstica, i els seus resultats es comparen favorablement amb els de ciproflozacina lliure soluble i els de ciprofloxacina encapsulada en pacients no tractats i amb nanopart\u00edules recobertes de poli-lisina.<\/p>\n<p>Els prometedors resultats, obtinguts juntament amb la citotoxicitat minima de les noves nanopart\u00edcules, obrint noves vies cap a l\u2019eradicaci\u00f3 dels biofilms bacterians establerts per la modificaci\u00f3 de la superf\u00edcie de les nanopart\u00edcules i, per tant, l&#8217;adaptaci\u00f3 d&#8217;ells\u00a0dirigida cap a infeccions bacterianes espec\u00edfiques.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Article de refer\u00e8ncia:<\/strong> <\/em>Aida Baelo, Ricardo Levato, Esther Juli\u00e1n, Anna Crespo, Jos\u00e9 Astola, Joan Gavald\u00e1, Elisabeth Engel, Miguel Angel Mateos-Timoneda, Eduard Torrents (2015). <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365915002588\">\u201cDisassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections\u201d<\/a>. <em>Journal of Controlled Release,<\/em> 209, p150\u2013158<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/04\/torrentsengel.jpg\" alt=\"torrentsengel\" width=\"336\" height=\"242\" class=\"left size-full wp-image-16405 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/04\/torrentsengel.jpg 336w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/04\/torrentsengel-300x216.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/04\/torrentsengel-180x130.jpg 180w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/04\/torrentsengel-150x108.jpg 150w\" data-sizes=\"(max-width: 336px) 100vw, 336px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 336px; --smush-placeholder-aspect-ratio: 336\/242;\" \/>Un estudi publicat avui a <em> Journal of Controlled Release <\/em> descriu una nova estrategia amb nanopart\u00edcules dirigida a infeccions dif\u00edcils d&#8217;abordar causades per biofilms formats per bacteries.<\/h3>\n<p>Dos grups del IBEC han treballat junts per desenvolupar un nou tipos de nanopart\u00edcula que pugui combatre les infeccions cr\u00f2niques causades per biofilms formats per bacteries. <\/p>\n","protected":false},"author":4,"featured_media":16407,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-16477","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dos grups del IBEC uneixen forces per combatre les infeccions bacterianes cr\u00f2niques - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dos grups del IBEC uneixen forces per combatre les infeccions bacterianes cr\u00f2niques - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi publicat avui a Journal of Controlled Release descriu una nova estrategia amb nanopart\u00edcules dirigida a infeccions dif\u00edcils d&#039;abordar causades per biofilms formats per bacteries. Dos grups del IBEC han treballat junts per desenvolupar un nou tipos de nanopart\u00edcula que pugui combatre les infeccions cr\u00f2niques causades per biofilms formats per bacteries.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-28T14:22:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-10-20T14:13:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/04\/torrentsengel.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"336\" \/>\n\t<meta property=\"og:image:height\" content=\"242\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Dos grups del IBEC uneixen forces per combatre les infeccions bacterianes cr\u00f2niques\",\"datePublished\":\"2015-04-28T14:22:49+00:00\",\"dateModified\":\"2015-10-20T14:13:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\\\/\"},\"wordCount\":420,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/04\\\/torrentsengel.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/dos-grups-del-ibec-uneixen-forces-per-combatre-les-infeccions-bacterianes-croniques\\\/\",\"name\":\"Dos grups del IBEC uneixen forces per combatre les infeccions bacterianes cr\u00f2niques - 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