{"id":17012,"date":"2015-06-12T12:03:02","date_gmt":"2015-06-12T12:03:02","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=17012"},"modified":"2015-06-15T09:50:16","modified_gmt":"2015-06-15T09:50:16","slug":"una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\/","title":{"rendered":"Una nova estrat\u00e8gia per a la mal\u00e0ria proposa utilitzar gl\u00f2buls vermells no afectats com a transportadors de f\u00e0rmacs"},"content":{"rendered":"

La nova estrat\u00e8gia proposa utilitzar gl\u00f2buls vermells no afectats com a transportadors de f\u00e0rmacs, assegurant aix\u00ed que el par\u00e0sit no t\u00e9 l’oportunitat d’iniciar el seu cicle de desenvolupament, el que normalment fa durant el “per\u00edode de recuperaci\u00f3” despr\u00e9s d’una entrada r\u00e0pida i silenciosa en els gl\u00f2buls vermells. “Les estrat\u00e8gies anteriors sempre han considerat les c\u00e8l\u00b7lules infectades com la diana,” diu Xavier Fern\u00e1ndez-Busquets, responsable de grup de la unitat de Nanomalaria. “Utilitzant les c\u00e8l\u00b7lules no infectades ens avancem a la infecci\u00f3 de Plasmodium assegurant-nos que quan intenti entrar a\u00a0una c\u00e8l\u00b7lula per assentar-se i cr\u00e9ixer, el f\u00e0rmac ja hi ser\u00e0.”<\/p>\n

Imatge: Representaci\u00f3 d’un model d’immunoliposoma encapsulant un f\u00e0rmac b\u00e0sic i funcionalizant-lo amb anticossos lligats a quatre estrat\u00e8gies de conjugaci\u00f3, totes basades en la formaci\u00f3 d’un enlla\u00e7 tio\u00e8ter entre un antic\u00f2s tiolat i un l\u00edpid conjugat amb maleimida.<\/h6>\n

Utilitzar gl\u00f2buls vermells no infectats t\u00e9 altres avantatges. Els gl\u00f2buls vermells s\u00f3n biocompatibles, i ja hi ha mecanismes naturals per a la seva eliminaci\u00f3 del cos, a difer\u00e8ncia d’altres nanotransportadores introdu\u00efts. Tamb\u00e9 tenen una llarga vida \u00fatil, el que significa que la circulaci\u00f3 del f\u00e0rmac es veu perllongada.<\/p>\n

Per descomptat, aquesta estrat\u00e8gia nom\u00e9s es pot utilitzar per a f\u00e0rmacs dels que ja se sap que no tenen cap efecte sobre el metabolisme dels gl\u00f2buls vermells, per\u00f2 Xavier confia que tals antipal\u00fadics es desenvoluparan en el futur.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/strong> Moles E, Urb\u00e1n P, Jim\u00e9nez-D\u00edaz MB, Viera-Morilla S, Angulo-Barturen I, Busquets MA, Fern\u00e0ndez-Busquets X. (2015). Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic\/prophylactic antimalarial strategy<\/a><\/strong>. J Control Release<\/em>, 210, 217-229<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"La unitat conjunta de l’IBEC i l’ISGlobal, Nanomalaria, ha publicat una nova estrat\u00e8gia terap\u00e8utica contra la Mal\u00e0ria.<\/h3>\n

L’estudi, publicat a Journal of Controlled Release<\/em>, ataca un obstacle important en els tractaments de Mal\u00e0ria, que \u00e9s que la majoria dels f\u00e0rmacs anti-mal\u00e0ria comencen a fer efecte en les c\u00e8l\u00b7lules infectades massa tard en el cicle vital de Plasmodium<\/em>, quan els seus efectes s\u00f3n sovint massa febles per a ser letals per al par\u00e0sit. El treball s’ha dut a terme en col\u00b7laboraci\u00f3 amb GlaxoSmithKline, com un dels pocs casos d’associaci\u00f3 entre la ind\u00fastria i la recerca en el desenvolupament de nanof\u00e0rmacs antipal\u00fadics innovadors.<\/p>\n","protected":false},"author":4,"featured_media":16967,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-17012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nUna nova estrat\u00e8gia per a la mal\u00e0ria proposa utilitzar gl\u00f2buls vermells no afectats com a transportadors de f\u00e0rmacs - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una nova estrat\u00e8gia per a la mal\u00e0ria proposa utilitzar gl\u00f2buls vermells no afectats com a transportadors de f\u00e0rmacs - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La unitat conjunta de l'IBEC i l'ISGlobal, Nanomalaria, ha publicat una nova estrat\u00e8gia terap\u00e8utica contra la Mal\u00e0ria. L'estudi, publicat a Journal of Controlled Release, ataca un obstacle important en els tractaments de Mal\u00e0ria, que \u00e9s que la majoria dels f\u00e0rmacs anti-mal\u00e0ria comencen a fer efecte en les c\u00e8l\u00b7lules infectades massa tard en el cicle vital de Plasmodium, quan els seus efectes s\u00f3n sovint massa febles per a ser letals per al par\u00e0sit. El treball s'ha dut a terme en col\u00b7laboraci\u00f3 amb GlaxoSmithKline, com un dels pocs casos d'associaci\u00f3 entre la ind\u00fastria i la recerca en el desenvolupament de nanof\u00e0rmacs antipal\u00fadics innovadors.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-06-12T12:03:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-06-15T09:50:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/06\/Malaria-JCR_XFB.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"429\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Una nova estrat\u00e8gia per a la mal\u00e0ria proposa utilitzar gl\u00f2buls vermells no afectats com a transportadors de f\u00e0rmacs\",\"datePublished\":\"2015-06-12T12:03:02+00:00\",\"dateModified\":\"2015-06-15T09:50:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\\\/\"},\"wordCount\":323,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/06\\\/Malaria-JCR_XFB.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-estrategia-per-a-la-malaria-proposa-utilitzar-globuls-vermells-no-afectats-com-a-transportadors-de-farmacs\\\/\",\"name\":\"Una nova estrat\u00e8gia per a la mal\u00e0ria proposa utilitzar gl\u00f2buls vermells no afectats com a transportadors de f\u00e0rmacs - 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