{"id":17064,"date":"2015-06-15T11:10:14","date_gmt":"2015-06-15T11:10:14","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=17064"},"modified":"2015-06-15T11:18:58","modified_gmt":"2015-06-15T11:18:58","slug":"les-cel%c2%b7lules-utilitzen-la-fisica-per-ser-mes-resistents","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-cel%c2%b7lules-utilitzen-la-fisica-per-ser-mes-resistents\/","title":{"rendered":"Les c\u00e8l\u00b7lules utilitzen la f\u00edsica per ser m\u00e9s resistents"},"content":{"rendered":"
C\u00e8l\u00b7lula despr\u00e9s d’haver modificat la seva \u00e0rea i el seu volum. En vermell es veuen els plecs que apareixen despr\u00e9s de l’estirament, i en verd els que apareixen despr\u00e9s del xoc osm\u00f2tic. En requadre inferior: zoom i vista vertical dels plecs.<\/h6>\n

Investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb l’Institut de Mecanobiologia de Singapur i la Universitat Polit\u00e8cnica de Barcelona (UPC), han descobert com es produeix aquest fenomen, demostrant que cada vegada que una c\u00e8l\u00b7lula es comprimeix o estira, forma o elimina petits plecs en la membrana que eviten que s’esquinci.<\/p>\n

El m\u00e9s fascinant d’aquest sistema \u00e9s la seva simplicitat: durant anys, multitud de grups de recerca a tot el m\u00f3n, han buscat complexos processos bioqu\u00edmics i moleculars per explicar com s’adapta la membrana. Aquest estudi, no obstant aix\u00f2, demostra que aplicant les lleis de la f\u00edsica i la mec\u00e0nica, les c\u00e8l\u00b7lules poden adaptar-se fins a extrems impensats.<\/p>\n

“Donat els continus canvis de forma cel\u00b7lular que ocorren en els processos cancer\u00edgens o durant la cicatritzaci\u00f3 de les ferides, les implicacions que t\u00e9 aquesta troballa s\u00f3n molt rellevants” diu Pere Roca-Cusachs, investigador principal de l’IBEC i professor lector de la Universitat de Barcelona, que ha liderat l’estudi. “El repte ara \u00e9s veure fins a quin punt aquesta nova comprensi\u00f3 ens pot permetre interferir en la progressi\u00f3 de tumors, millorar la regeneraci\u00f3 de teixits, o solucionar problemes en malalties respirat\u00f2ries i cardiovasculars”, afegeix.<\/p>\n

L’estudi, que es publica avui en la revista Nature Communications, desvetlla com l’\u00e0rea de la membrana cel\u00b7lular pot augmentar o disminuir per acomodar la forma de la c\u00e8l\u00b7lula de forma pr\u00e0cticament immediata, la qual cosa \u00e9s essencial en processos vitals com la respiraci\u00f3 o el batec del cor.<\/p>\n

“Per realitzar aquest estudi, hem comprovat l’adaptaci\u00f3 de les c\u00e8l\u00b7lules despr\u00e9s de canviar la seva \u00e0rea (estirant-les) i el seu volum (introduint aigua en el seu interior mitjan\u00e7ant un xoc osm\u00f2tic)” diu Anita J. Kosmalska, investigadora de l’IBEC i primera autora de l’estudi. “En tots dos casos, sense necessitat de tenir en compte la complexitat biol\u00f2gica de les c\u00e8l\u00b7lules, les lleis de la mec\u00e0nica i la f\u00edsica per si soles s\u00f3n capaces d’explicar on es formen o eliminen plecs, quina forma tenen, i com protegeixen la membrana cel\u00b7lular de la seva ruptura”, afegeix.<\/p>\n

—<\/p>\n

Reference article:<\/strong> <\/em>Anita Joanna Kosmalska, Laura Casares, Alberto Elosegui-Artola, Joseph Jose Thottacherry, Roberto Moreno-Vicente, Victor Gonz\u00e1lez-Tarrago, Miguel Angel del Pozo, Satyajit Mayor, Marino Arroyo, Daniel Navajas, Xavier Trepat, Nils C. Gauthier & Pere Roca-Cusachs (2015).\u201cPhysical principles of membrane remodelling during cell mechanoadaptation\u201d. Nature Communications<\/em>, 10.1038\/ncomms8292<\/p>\n","protected":false},"excerpt":{"rendered":"

\"opcioUn estudi de l’Institut de Bioenginyeria de Catalunya (IBEC) revela com les c\u00e8l\u00b7lules eviten trencar-se durant les cont\u00ednues deformacions que sofreixen en la majoria de processos biol\u00f2gics<\/h3>\n

Durant processos biol\u00f2gics cr\u00edtics com el desenvolupament embrionari, la respiraci\u00f3, el bombament del cor, la curaci\u00f3 de ferides o el creixement de tumors, milions de c\u00e8l\u00b7lules s’estiren i es deformen per adaptar-se al seu entorn. La membrana que embolica la c\u00e8l\u00b7lula, encara que r\u00edgida i poc flexible, suporta totes aquestes deformacions utilitzant un sistema, fins ara desconegut, que evita la seva ruptura.<\/p>\n","protected":false},"author":4,"featured_media":17049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-17064","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nLes c\u00e8l\u00b7lules utilitzen la f\u00edsica per ser m\u00e9s resistents - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/les-cel\u00b7lules-utilitzen-la-fisica-per-ser-mes-resistents\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les c\u00e8l\u00b7lules utilitzen la f\u00edsica per ser m\u00e9s resistents - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi de l'Institut de Bioenginyeria de Catalunya (IBEC) revela com les c\u00e8l\u00b7lules eviten trencar-se durant les cont\u00ednues deformacions que sofreixen en la majoria de processos biol\u00f2gics Durant processos biol\u00f2gics cr\u00edtics com el desenvolupament embrionari, la respiraci\u00f3, el bombament del cor, la curaci\u00f3 de ferides o el creixement de tumors, milions de c\u00e8l\u00b7lules s'estiren i es deformen per adaptar-se al seu entorn. 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