{"id":19135,"date":"2015-10-06T07:39:54","date_gmt":"2015-10-06T07:39:54","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=19135"},"modified":"2015-10-20T13:43:41","modified_gmt":"2015-10-20T13:43:41","slug":"nanomotors-biocompatibles-propulsats-amb-sucre","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/nanomotors-biocompatibles-propulsats-amb-sucre\/","title":{"rendered":"Nanomotors biocompatibles propulsats amb sucre"},"content":{"rendered":"

Aquest nou minimotor biocompatible est\u00e0 fet a partir de s\u00edlice mesopor\u00f3s, que \u00e9s buit, i que a m\u00e9s no \u00e9s nociu per a les c\u00e8l\u00b7lules ni per als teixits. Es podr\u00e0 utilitzar en moltes aplicacions biom\u00e8diques, ja que la seva propulsi\u00f3 \u00e9s deguda a la reacci\u00f3 catal\u00edtica de tres enzims que es troben de forma natural el cos; la catalasa, la ureasa i la glucosa oxidasa. Les reaccions enzim\u00e0tiques donen energia a les nanopart\u00edcules Janus -part\u00edcules amb dues cares amb propietats f\u00edsiques diferents-, tenint lloc de forma asim\u00e8trica en nom\u00e9s una de les cares del nanomotor, la qual cosa provoca la propulsi\u00f3 en la direcci\u00f3 oposada.<\/p>\n

\u201cPerqu\u00e8 el seu \u00fas sigui segur en aplicacions biom\u00e8diques a l\u2019interior de l\u2019organisme, les nanopart\u00edcules han de ser de materials biocompatibles i biodegradables, han de tenir la capacitat de moure\u2019s de forma aut\u00f2noma utilitzant combustibles d\u2019origen biol\u00f2gic i d\u2019alliberar la c\u00e0rrega en un punt determinat \u2013com seria el cas de l\u2019alliberament de f\u00e0rmacs\u2013 a la petita escala\u201d, diu Samuel S\u00e1nchez, qui dirigeix al que ha estat descrit com \u201cun dels grups capdavanters en el camp de la recerca en nanomotors\u201d, el grup de Dispositius Intel\u00b7ligents Nano-Bio de l\u2019IBEC i del MPI-IS de Stuttgart. \u201cHem aconseguit totes aquestes propietats amb els nostres nous nanomotors. Per a la seva arquitectura, hem utilitzat un material que ofereix una gran capacitat d\u2019alliberament de f\u00e0rmacs a causa de la seva estructura buida; i per a la propulsi\u00f3, hem basat els nostres m\u00e8todes en el recent descobriment que els enzims poden actuar com nanomotors autopropulsats, aix\u00ed com de ser ancorades a objectes artificials majors, com els nanotubs de carboni, per proporcionar una for\u00e7a de propulsi\u00f3 utilitzant reaccions catal\u00edtiques\u201d.<\/p>\n

Aquest tipus de reaccions biocatal\u00edtiques desencadenades per enzims actuen a manera de propulsi\u00f3 no-t\u00f2xica perqu\u00e8 que estan presents en l\u2019ambient biol\u00f2gic i tenen un elevat potencial de reacci\u00f3. Es poden utilitzar diferents combinacions d\u2019enzim\/combustible com la catalasa i el per\u00f2xid d\u2019hidrogen o la glucosa i la glucosa oxidasa, la qual cosa significa que el m\u00e8tode \u00e9s molt vers\u00e0til amb un potencial que es podr\u00e0 estendre a altres enzims.<\/p>\n

Els micro i nanosistemes desenvolupats anteriorment estaven molt limitats per ser utilitzats en l\u2019\u00e0mbit biom\u00e8dic, ja que per propulsar-se utilitzaven la descomposici\u00f3 de per\u00f2xid d\u2019hidrogen amb plat\u00ed com a catalitzador, la qual cosa provocava que en alguns casos la propulsi\u00f3 dur\u00e9s molt poc o, senzillament, es convertissin en nanosistemes passius incapa\u00e7os de moure\u2019s de forma aut\u00f2noma.<\/p>\n

El seg\u00fcent pas ser\u00e0 explorar com incrementar la for\u00e7a conductora i la guia dels seus nanomotors biocompatibles mitjan\u00e7ant m\u00e8todes de manipulaci\u00f3 externa, com la quimiotaxi, el control magn\u00e8tic o els ultrasons, dirigint-los a un moviment direccional per a l\u2019alliberament actiu de f\u00e0rmacs en localitzacions espec\u00edfiques.<\/p>\n

Els col\u00b7laboradors de la Universitat de T\u00fcbingen tamb\u00e9 han mesurat, per primera vegada, mitjan\u00e7ant unes pinces \u00f2ptiques, la for\u00e7a de propulsi\u00f3 dels nanomotors, la qual cosa fa possible entendre una mica m\u00e9s com es comporten les nanopart\u00edcules propulsades.<\/p>\n

\u2014 Xing Ma, Anita Jannasch, Urban-Raphael Albrecht, Kersten Hahn, Albert Miguel-L\u00f3pez, Erik Sch\u00e4ffer and Samuel Sanchez (2015). Enzyme-Powered Hollow Mesoporous Janus Nanomotors<\/a>. Nano Lett.<\/em>, 15<\/span> (10), pp 7043\u20137050<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadors de l\u2019IBEC i els seus col\u00b7laboradors han desenvolupat nanomotors per a aplicacions biom\u00e8diques que s\u00f3n propulsats per enzims, com la glucosa oxidasa, que els fa completament biocompatibles.<\/h3>\n

En un estudi publicat avui en Nanoletters<\/em>, el Prof. Samuel S\u00e1nchez, responsable de grup de l\u2019IBEC i investigador ICREA, i els seus col\u00b7laboradors en el Max Planck Institute for Intelligent Systems (MPI-IS), la Universitat de T\u00fcbingen i el Max Planck for Solid State Research, a Alemanya, descriuen la fabricaci\u00f3 del primer nanomotor sint\u00e8tic al m\u00f3n propulsat per un enzim que utilitza combustible biocompatible, la qual cosa soluciona els desavantatges dels sistemes actuals. <\/p>\n","protected":false},"author":4,"featured_media":19123,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-19135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nNanomotors biocompatibles propulsats amb sucre - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/nanomotors-biocompatibles-propulsats-amb-sucre\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanomotors biocompatibles propulsats amb sucre - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019IBEC i els seus col\u00b7laboradors han desenvolupat nanomotors per a aplicacions biom\u00e8diques que s\u00f3n propulsats per enzims, com la glucosa oxidasa, que els fa completament biocompatibles. En un estudi publicat avui en Nanoletters, el Prof. Samuel S\u00e1nchez, responsable de grup de l\u2019IBEC i investigador ICREA, i els seus col\u00b7laboradors en el Max Planck Institute for Intelligent Systems (MPI-IS), la Universitat de T\u00fcbingen i el Max Planck for Solid State Research, a Alemanya, descriuen la fabricaci\u00f3 del primer nanomotor sint\u00e8tic al m\u00f3n propulsat per un enzim que utilitza combustible biocompatible, la qual cosa soluciona els desavantatges dels sistemes actuals.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/nanomotors-biocompatibles-propulsats-amb-sucre\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-10-06T07:39:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-10-20T13:43:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/10\/JHMSNPNi-enzyme_for-web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"373\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/nanomotors-biocompatibles-propulsats-amb-sucre\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/nanomotors-biocompatibles-propulsats-amb-sucre\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Nanomotors biocompatibles propulsats amb sucre\",\"datePublished\":\"2015-10-06T07:39:54+00:00\",\"dateModified\":\"2015-10-20T13:43:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/nanomotors-biocompatibles-propulsats-amb-sucre\\\/\"},\"wordCount\":580,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/nanomotors-biocompatibles-propulsats-amb-sucre\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/10\\\/JHMSNPNi-enzyme_for-web.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/nanomotors-biocompatibles-propulsats-amb-sucre\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/nanomotors-biocompatibles-propulsats-amb-sucre\\\/\",\"name\":\"Nanomotors biocompatibles propulsats amb sucre - 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