{"id":19166,"date":"2015-10-12T11:00:29","date_gmt":"2015-10-12T11:00:29","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=19166"},"modified":"2015-10-13T14:10:53","modified_gmt":"2015-10-13T14:10:53","slug":"un-micobacteri-podria-substituir-el-tractament-actual-del-cancer-de-bufeta","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-micobacteri-podria-substituir-el-tractament-actual-del-cancer-de-bufeta\/","title":{"rendered":"Un micobacteri podria substituir el tractament actual del c\u00e0ncer de bufeta"},"content":{"rendered":"<p>La recerca, iniciada fa set anys pel grup de Recerca en Micobacteris i dirigida per la doctora Esther Juli\u00e1n, del Departament de Gen\u00e8tica i de Microbiologia de la Universitat Aut\u00f2noma de Barcelona, ha donat lloc al descobriment de la capacitat antitumoral del <em>Mycobacterium brumae.<\/em> Els investigadors han estudiat les caracter\u00edstiques d\u2019un ampli grup de micobacteris i han demostrat que, de tots ells, <em>M. brumae<\/em> \u00e9s capa\u00e7 de reduir el creixement de les c\u00e8l\u00b7lules tumorals de bufeta i d\u2019activar una resposta immunol\u00f2gica.<\/p>\n<p>Els estudis precl\u00ednics duts a terme amb ratolins model de c\u00e0ncer de bufeta han demostrat l\u2019efic\u00e0cia del micobacteri <em>M. brumae<\/em> en el tractament d\u2019aquesta malaltia. Els ratolins amb tumor de bufeta que han estat tractats amb <em>M. brumae<\/em> de la mateixa manera que es tracten els pacients, sobreviuen m\u00e9s temps que els no tractats i, fins i tot, en una major proporci\u00f3 que els tractats amb el micobacteri habitual, el BCG.<\/p>\n<p>Els estudis realitzats a la UAB tamb\u00e9 han demostrat que <em>M. brumae<\/em> no \u00e9s patogen, \u00e9s a dir, no t\u00e9 risc de provocar infeccions. La investigaci\u00f3 indica, per tant, que tindria menys efectes adversos en els pacients que els que actualment presenta el BCG.<\/p>\n<p>A m\u00e9s, el fet que el <em>M. brumae<\/em> sigui un micobacteri de creixement r\u00e0pid i no patogen fa que la seva producci\u00f3 a gran escala sigui m\u00e9s senzilla i r\u00e0pida que la producci\u00f3 de BCG. De fet, en els \u00faltims anys les dificultats per produir el BCG han estat provocant problemes en el seu subministrament per al tractament dels malalts amb c\u00e0ncer de bufeta.<\/p>\n<p>\u201cEls resultats obtinguts indiquen que el <em>Micobacterium brumae<\/em> \u00e9s un candidat idoni per a substituir al tractament actual amb BCG per al c\u00e0ncer superficial de bufeta\u201d, conclou la investigadora de la UAB Esther Juli\u00e1n.<\/p>\n<p>El treball, publicat a la revista<em> European Urology Focus,<\/em> ha estat realitzat en col\u00b7laboraci\u00f3 amb la doctora Rosa M. Rabanal de la Unitat de Patologia Murina i Comparada del Departament de Medicina i Cirurgia Animals de la UAB, i el grup <em>Bacterial Infections and Antimicrobial Therapies<\/em> liderat pel doctor Eduard Torrents, de l\u2019Institut de Bioenginyeria de Catalunya (IBEC).<\/p>\n<p><strong>Article de refer\u00e8ncia:<\/strong><\/p>\n<p>Noguera-Ortega E, Secanella-Fandos S, Era\u00f1a H, Gasi\u00f3n J, Rabanal RM, Luquin M, Torrents E, and Juli\u00e1n E. (2015) The non-pathogenic Mycobacterium brumae inhibits bladder cancer growth in vitro, ex vivo, and in vivo. European Urology FOCUS. DOI: 10.1016\/j.euf.2015.03.003.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/10\/Micobacteriumbrumae.jpg\" alt=\"\" width=\"400\" height=\"373\" class=\"left size-full wp-image-19121 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/373;\" \/>Una col\u00b7laboraci\u00f3 de l&#8217;IBEC amb Investigadors de la UAB posa al descobert un micobacteri m\u00e9s efectiu per tractar el c\u00e0ncer de bufeta superficial que, a difer\u00e8ncia dels emprats actualment, no t\u00e9 risc de provocar infeccions.<\/h3>\n<p>Els micobacteris s\u00f3n els \u00fanics bacteris que s\u2019utilitzen per al tractament del c\u00e0ncer. En el cas del c\u00e0ncer de bufeta superficial, el micobacteri Mycobacterium bovis (BCG) s\u2019administra a trav\u00e9s d\u2019un cat\u00e8ter directament dins la bufeta en els pacients, despr\u00e9s de l\u2019extirpaci\u00f3 del tumor. El BCG evita l\u2019aparici\u00f3 de nous tumors per\u00f2, malgrat la seva efic\u00e0cia, aquest tractament comporta nombrosos efectes adversos, i els m\u00e9s greus d\u2019ells s\u00f3n casos d\u2019infeccions per BCG que han de tractar-se amb f\u00e0rmacs antituberculosos.<\/p>\n","protected":false},"author":4,"featured_media":19159,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-19166","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un micobacteri podria substituir el tractament actual del c\u00e0ncer de bufeta - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-micobacteri-podria-substituir-el-tractament-actual-del-cancer-de-bufeta\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un micobacteri podria substituir el tractament actual del c\u00e0ncer de bufeta - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Una col\u00b7laboraci\u00f3 de l&#039;IBEC amb Investigadors de la UAB posa al descobert un micobacteri m\u00e9s efectiu per tractar el c\u00e0ncer de bufeta superficial que, a difer\u00e8ncia dels emprats actualment, no t\u00e9 risc de provocar infeccions.  Els micobacteris s\u00f3n els \u00fanics bacteris que s\u2019utilitzen per al tractament del c\u00e0ncer. En el cas del c\u00e0ncer de bufeta superficial, el micobacteri Mycobacterium bovis (BCG) s\u2019administra a trav\u00e9s d\u2019un cat\u00e8ter directament dins la bufeta en els pacients, despr\u00e9s de l\u2019extirpaci\u00f3 del tumor. 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