{"id":20348,"date":"2015-12-17T10:29:38","date_gmt":"2015-12-17T10:29:38","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=20348"},"modified":"2015-12-21T08:29:33","modified_gmt":"2015-12-21T08:29:33","slug":"propietats-de-les-microones-electromagnetiques-de-cel%c2%b7lules-bacterianes-individuals-mesures-per-primera-vegada","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/propietats-de-les-microones-electromagnetiques-de-cel%c2%b7lules-bacterianes-individuals-mesures-per-primera-vegada\/","title":{"rendered":"Propietats electromagn\u00e8tiques de c\u00e8l\u00b7lules bacterianes individuals a freq\u00fc\u00e8ncies de microones mesurades per primera vegada"},"content":{"rendered":"<h6 class=\"caption\" style=\"padding: 0px 10px 10px 30px;\"><em>Imatge: Com la microscopia d&#8217;escombrat de microones mesura la permitivitat el\u00e8ctrica d&#8217;un objecte biol\u00f2gic a escala nanom\u00e8trica.<\/em><\/h6>\n<p>Havent mesurat la polaritzabilitat el\u00e8ctrica de l\u2019ADN i de c\u00e8l\u00b7lules bacterianes individuals a baixes freq\u00fc\u00e8ncies (kHz) el 2014 i la dels principals components de la membrana cel\u00b7lular aquest any, el grup de Caracteritzaci\u00f3 Bioel\u00e8ctrica a la Nanoescala ha aconseguit aquest nou avan\u00e7 mitjan\u00e7ant l\u2019\u00fas d\u2019una t\u00e8cnica coneguda com a microsc\u00f2pia d\u2019escombrat de microones. Amb aquesta t\u00e8cnica es poden realitzar imatges d&#8217;una \u00fanica c\u00e8l\u00b7lula o microorganisme, en aquest cas una c\u00e8l\u00b7lula bacteriana, utilitzant microones, similars a les que es fan servir en la telefonia m\u00f2bil per a comunicar-nos o en els microones, i aix\u00ed quantificar a la nanoescala les propietats electromagn\u00e8tiques amb gran precisi\u00f3 i reproductibilitat.<\/p>\n<p>\u201cNous aven\u00e7os en t\u00e8cniques d\u2019imatge m\u00e8dica no-invasives per al diagn\u00f2stic de c\u00e0ncer, t\u00e8cniques d\u2019ablaci\u00f3 terap\u00e8utiques per al tractament del c\u00e0ncer i noves t\u00e8cniques d\u2019electrocirurgia estan en proc\u00e9s de ser desenvolupades basant-se en l\u2019\u00fas de les microones i en el coneixement de les propietats electromagn\u00e8tiques d\u2019alta freq\u00fc\u00e8ncia \u2013 la permitivitat complexa \u2013 dels teixits biol\u00f2gics\u201d, explica Gabriel Gomila, qui va liderar la investigaci\u00f3.\u201cAra, hem demostrat la possibilitat de mesurar aquestes propietats f\u00edsiques clau tamb\u00e9 a escala unicel\u00b7lular, el que ens proporciona un major coneixement sobre la interacci\u00f3 de les microones amb els ens biol\u00f2gics i aplana el cam\u00ed cap a noves aplicacions m\u00e8diques de les microones.\u201d<\/p>\n<p>Els investigadors han quantificat la permitivitat el\u00e8ctrica d\u2019una c\u00e8l\u00b7lula individual d\u2019<em>Escherichia coli,\u00a0<\/em>demostrant aix\u00ed que la seva t\u00e8cnica pot detectar la pres\u00e8ncia d\u2019estructures a escales molt petites fins i tot a l\u2019interior dels microorganismes, proporcionant aix\u00ed una infinitat d\u2019aplicacions en la realitzaci\u00f3 d&#8217;imatges sense marcadars de c\u00e8l\u00b7lules bacterianes individuals en alta resoluci\u00f3 espacial, i en general, en c\u00e8l\u00b7lules eucariotes.<\/p>\n<p>\u201cRevelar la permitivitat complexa d\u2019una \u00fanica c\u00e8l\u00b7lula pot proporcionar informaci\u00f3 \u00fanica sobre la seva estructura interna i la composici\u00f3 bioqu\u00edmica, i sobre el seu estat i fase,\u201d diu en Gabriel. \u201cAix\u00f2 tamb\u00e9 pot emprar-se per dissenyar i implementar t\u00e8cniques el\u00e8ctriques lliures de marcadors per al recompte, la mesura, la separaci\u00f3 i la identificaci\u00f3 de c\u00e8l\u00b7lules, i per tant pot obrir encara m\u00e9s vies cap a noves i millorades aplicacions biol\u00f2giques i m\u00e8diques.\u201d<\/p>\n<p>&#8212;<\/p>\n<p>Maria Chiara Biagi, Ren\u00e9 F\u00e1bregas, Georg Gramse, Marc Van Der Hofstadt, Antonio Ju\u00e1rez, Ferry Kienberger, Laura Fumagalli and Gabriel Gomila (2015). <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.5b04279\">\u201cNanoscale electric permittivity of single bacterial cells at GHz frequencies by scanning microwave microscopy\u201d<\/a>. <em>ACS Nano<\/em>, epub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" 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Universitat de Manchester i la companyia Keysight Technologies han aconseguit un objectiu dif\u00edcil d\u2019assolir: mesurar les propietats electromagn\u00e8tiques de materials biol\u00f2gics al nivell de c\u00e8l\u00b7lules bacterianes individuals a freq\u00fc\u00e8ncies molt altes (gigahertzs).<\/h3>\n","protected":false},"author":4,"featured_media":20290,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-20348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Propietats electromagn\u00e8tiques de c\u00e8l\u00b7lules bacterianes individuals a freq\u00fc\u00e8ncies de microones mesurades per primera vegada - Institute for Bioengineering of 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