{"id":20442,"date":"2015-12-22T12:28:15","date_gmt":"2015-12-22T12:28:15","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=20442"},"modified":"2016-06-11T18:31:15","modified_gmt":"2016-06-11T18:31:15","slug":"tecnologies-de-disminucio-per-aprofundir-en-els-secrets-de-lorganisme","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/tecnologies-de-disminucio-per-aprofundir-en-els-secrets-de-lorganisme\/","title":{"rendered":"Tecnologies de disminuci\u00f3 per aprofundir en els secrets de l’organisme"},"content":{"rendered":"

En el projecte, liderat pel Consell Superior de Recerques Cient\u00edfiques (CSIC), ha participat Juan Pablo Agusil, qui durant l’estudi desenvolupava la seva labor cient\u00edfica en l’Institut de Bioenginyeria de Catalunya (IBEC) i en l’actualitat pertany a l’Institut de Microelectr\u00f2nica de Barcelona, del CSIC. En el treball tamb\u00e9 ha col\u00b7laborat el Centro de Investigaciones Biol\u00f3gicas de Madrid, del CSIC, i l’Institut de Nanociencia i Nanotecnologia, de la Universitat de Barcelona.<\/p>\n

\u201cLes dues metodologies pr\u00e8vies, Planar array chips<\/em> i Suspension arrays of particles<\/em>, s’han utilitzat durant molt temps per estudiar les interaccions biomoleculars i dur a terme an\u00e0lisis moleculars complexos\u201d, explica Juan Pablo. \u201cPer\u00f2 encara que la tecnologia Planar array chips<\/em>\u00a0 ra bona per la *multiplexaci\u00f3n molecular -provar una s\u00e8rie de components independents en una \u00fanica plataforma per a la r\u00e0pida identificaci\u00f3 individual de m\u00faltiples elements- el dispositiu era massa gran per a volums excepcionalment petits; i a l’inrev\u00e9s, encara que la tecnologia Suspension arrays of particles<\/em> permetia l’an\u00e0lisi de volums petits, no permetia la detecci\u00f3 m\u00faltiple en un \u00fanic dispositiu.<\/p>\n

Per solucionar aix\u00f2, els investigadors han combinat els aspectes avantatjosos d’ambdues t\u00e8cniques per desenvolupar la nova tecnologia Suspended Planar-Array chips<\/em>, que s\u00ed que \u00e9s capa\u00e7 de combinar la multiplexaci\u00f3 molecular amb els volums excepcionalment petits. B\u00e0sicament, han miniaturitzat una matriu plana t\u00edpica a una escala de 1010<\/sup>. \u201cUtilitzant solament un d’aquests dispositius nosaltres podem entrar en la c\u00e8l\u00b7lula i realitzar deteccions m\u00faltiples de par\u00e0metres biol\u00f2gics\u201d, diu Juan Pablo Agusil. \u201cAquesta \u00e9s la primera vegada que la multiplexaci\u00f3n s’ha fet a l’interior d’una c\u00e8l\u00b7lula viva\u201d.<\/p>\n

Utilitzant els seus xips, els investigadors ja han demostrat que el moviment d’ions d’hidrogen a trav\u00e9s de les membranes cel\u00b7lulars de c\u00e8l\u00b7lules HeLa, obrint aix\u00ed el cam\u00ed per a estudis futurs de m\u00faltiples fen\u00f2mens moleculars que succeeixen a l’interior cel\u00b7lular de forma simult\u00e0nia. \u201cLa naturalesa interdisciplin\u00e0ria, la versatilitat i el potencial de la nostra t\u00e8cnica pot ser de gran inter\u00e8s per als cient\u00edfics que treballen en moltes disciplines diferents com els biomaterials, l’enginyeria, la tecnologia de xips, la impressi\u00f3 o el autoassemblatge de nanocapes, la biologia cel\u00b7lular i la nanotecnologia\u201d, diu Juan Pablo.<\/p>\n

—<\/p>\n

N\u00faria Torras, Juan Pablo Agusil, Patricia V\u00e1zquez, Marta Duch, Alberto M. Hern\u00e1ndez-Pinto, Josep Samitier, Enrique J. de la Rosa, Jaume Esteve, Teresa Su\u00e1rez, Llu\u00efsa P\u00e9rez-Garc\u00eda and Jos\u00e9 A. Plaza (2015). Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale<\/a>. Advanced Materials<\/em>, 17;28(7):1449-54<\/p>\n

—<\/p>\n

IBEC als Mitjans:<\/strong> http:\/\/www.larazon.es\/sociedad\/ciencia\/desarrollan-chips-miniaturizados-capaces-de-detectar-enfermedades-desde-el-interior-de-la-celula-viva-DD11479802#.Ttt14cfhFOMbXpr<\/a> http:\/\/www.elpuntavui.cat\/societat\/article\/15-ciencia\/924253-xips-miniaturitzats-per-detectar-malalties.html<\/a> 2015 12 17 JPAgusil DiarioMedico<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"AdvancedUn equip d’investigadors amb participaci\u00f3 de l’IBEC ha desenvolupat una nova t\u00e8cnica que miniaturitza la manera en la qual s’estudien les interaccions biomoleculars, permetent per primera vegada fer an\u00e0lisis a l’interior de les c\u00e8l\u00b7lules vives.<\/h3>\n

L’estudi, publicat avui en la revista Advanced Materials<\/em>, descriu una nova tecnologia anomenada Suspended Planar-Array chips, l’extraordinari grau dels quals de miniaturitzaci\u00f3 permet el seu \u00fas a la microescala. La nova t\u00e8cnica utilitza un \u00fanic xip per identificar, quantificar i determinar els canvis bioqu\u00edmics i fisiol\u00f2gics en volums petits, una reducci\u00f3 tan gran que fins i tot permet l’an\u00e0lisi a l’interior de les c\u00e8l\u00b7lules vives.<\/p>\n","protected":false},"author":4,"featured_media":20389,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-20442","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nTecnologies de disminuci\u00f3 per aprofundir en els secrets de l'organisme - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/tecnologies-de-disminucio-per-aprofundir-en-els-secrets-de-lorganisme\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tecnologies de disminuci\u00f3 per aprofundir en els secrets de l'organisme - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equip d'investigadors amb participaci\u00f3 de l'IBEC ha desenvolupat una nova t\u00e8cnica que miniaturitza la manera en la qual s'estudien les interaccions biomoleculars, permetent per primera vegada fer an\u00e0lisis a l'interior de les c\u00e8l\u00b7lules vives. 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