{"id":21634,"date":"2016-02-15T08:35:16","date_gmt":"2016-02-15T07:35:16","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=21634"},"modified":"2022-01-03T10:24:00","modified_gmt":"2022-01-03T09:24:00","slug":"el-nou-investigador-principal-de-libec-vito-conte","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/el-nou-investigador-principal-de-libec-vito-conte\/","title":{"rendered":"El nou investigador principal de l’IBEC: Vito Conte"},"content":{"rendered":"

Els models in silico<\/em> del Vito tindran geometries realistes i les propietats del material, tals com l’anisotropia, l’heterogene\u00eftat, la poroelasticitat, i la viscoelasticitat no lineal. Aquests models permetran al grup realitzar an\u00e0lisi biomec\u00e0nics predictius d’organismes mitjan\u00e7ant l’estudi de les condicions necess\u00e0ries per al seu desenvolupament normal – i, d’altra banda, per al desenvolupament d’una possible malaltia – en ambients molt similars a les condicions reals.<\/p>\n

“Les nostres recerques actuals se centren en la mec\u00e0nica de la progressi\u00f3 del c\u00e0ncer”, explica Vito. “Existeix una evid\u00e8ncia creixent que la progressi\u00f3 del c\u00e0ncer altera les propietats mec\u00e0niques de les c\u00e8l\u00b7lules i els teixits afectats. No obstant aix\u00f2, no sabem si aquestes alteracions s’alimenten de nou en la progressi\u00f3 del c\u00e0ncer; si ho fan, poden representar una forma d’obstaculitzar o detenir la malaltia biomec\u00e0nicament.” En desvetllar la interacci\u00f3 entre la mec\u00e0nica i els tumors malignes dels teixits, el grup identificar\u00e0 nous marcadors biomec\u00e0nics o mecanismes f\u00edsics de la progressi\u00f3 del c\u00e0ncer que podrien servir per prevenir i tractar la malaltia cl\u00ednicament – per exemple, la rigidesa dels teixits tumorals en comparaci\u00f3 de la suavitat de les c\u00e8l\u00b7lules canceroses.<\/p>\n

Una altra \u00e0rea d’inter\u00e8s pel Vito i el seu grup \u00e9s la interacci\u00f3 entre els mecanismes d’acci\u00f3 dels antibi\u00f2tics i la resist\u00e8ncia bacteriana, la qual cosa podria donar lloc a ter\u00e0pies dirigides a disminuir la resist\u00e8ncia bacteriana als medicaments coneguts, aix\u00ed com ajudar en el disseny de nous f\u00e0rmacs. “El creixent consens \u00e9s que alguns medicaments antibi\u00f2tics maten als bacteris a trav\u00e9s de reaccions bioqu\u00edmiques que possiblement podrien implicar processos mec\u00e0nics, tals com la generaci\u00f3 de forces en l’embolcall cel\u00b7lular bacteri\u00e0”, diu el Vito. “A mesura que els bacteris han evolucionat de forma selectiva la resist\u00e8ncia als antibi\u00f2tics a trav\u00e9s de mecanismes cada vegada m\u00e9s sofisticats, aquests processos poden en \u00faltima inst\u00e0ncia implicar un canvi de les propietats mec\u00e0niques d’aquests microorganismes procariotes, oferint aix\u00ed un cam\u00ed potencial per disminuir la resist\u00e8ncia de l’organisme o augmentar l’efici\u00e8ncia de drogues.”<\/p>\n

El Vito ja est\u00e0 treballant amb el grup del Lorenzo Albertazzi, un altre investigador principal recentment incorporat a l’IBEC, en aquest projecte, per\u00f2 est\u00e0 disposat a entaular col\u00b7laboracions amb altres grups de l’institut i d’altres llocs, aix\u00ed com amb els metges i els socis de la ind\u00fastria. “Estic molt feli\u00e7 de compartir la meva experi\u00e8ncia en la quantificaci\u00f3 biomec\u00e0nica dels fen\u00f2mens biol\u00f2gics”, diu. “Per a la quantificaci\u00f3 de dades que necessitem, aix\u00ed que \u00e9s un bon lloc per comen\u00e7ar!”<\/p>\n

Ara com ara, Vito s’est\u00e0 concentrant en la construcci\u00f3 del seu grup i a instal\u00b7lar-se en la seva nova posici\u00f3. “Quan ets un brot sorgit d’un arbre tan gran com el Xavier Trepat, \u00e9s un repte acabar amb les teves pr\u00f2pies arrels”, diu. “Estic encantat de tenir aquesta fant\u00e0stica oportunitat de comen\u00e7ar el meu propi grup de recerca independent en l’IBEC, tant per fer la meva pr\u00f2pia contribuci\u00f3 a la seva reputaci\u00f3 cient\u00edfica, si no tamb\u00e9 per aprofitar al m\u00e0xim les oportunitats que ofereix per dur a terme un treball multidisciplinari, construir col\u00b7laboracions fortes i desenvolupar els resultats de la recerca b\u00e0sica en productes que benefici\u00efn a la societat”<\/p>\n","protected":false},"excerpt":{"rendered":"

\"vitoconte\"Molts coneixereu a Vito Conte, despr\u00e9s d’haver passat m\u00e9s de quatre anys en el grup d’Integraci\u00f3 cel\u00b7lular i din\u00e0mica de teixits liderat per Xavier Trepat, primer com a post-doctorant i m\u00e9s tard com a membre Juan de la Cierva. Vito ara t\u00e9 una beca Ram\u00f3n i Cajal i \u00e9s l’investigador principal del grup Mec\u00e0nica del desenvolupament i la malaltia, la intenci\u00f3 de la qual \u00e9s desenvolupar noves eines biof\u00edsiques per quantificar la mec\u00e0nica de les c\u00e8l\u00b7lules i teixits en entorns 3D.<\/h3>\n

“Amb una gran experi\u00e8ncia en l’estudi de com la mec\u00e0nica de les c\u00e8l\u00b7lules i teixits determinen l’estructura i funci\u00f3 durant el meu temps com post-doctorant, vull continuar explorant els mecanismes f\u00edsics del desenvolupament i de la malaltia en els organismes biol\u00f2gics”, diu Vito, qui va completar el seu doctorat en enginyeria biomec\u00e0nica en el Kings College de Londres en el grup del Prof. Marcos Miodownik, ara director de l’Institut de Fabricaci\u00f3 en la UCL. “Per fer aix\u00f2, el meu grup va a desenvolupar noves eines per dur a terme mesuraments mec\u00e0nics in vivo<\/em> i in vitro<\/em>, amb les quals anem a integrar en models 2D i 3D dels organismes biol\u00f2gics estudiats.”<\/p>\n","protected":false},"author":4,"featured_media":21597,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1577],"post_formats":[],"class_list":["post-21634","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-vito-conte-ca"],"yoast_head":"\nEl nou investigador principal de l'IBEC: Vito Conte - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/el-nou-investigador-principal-de-libec-vito-conte\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El nou investigador principal de l'IBEC: Vito Conte - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Molts coneixereu a Vito Conte, despr\u00e9s d'haver passat m\u00e9s de quatre anys en el grup d'Integraci\u00f3 cel\u00b7lular i din\u00e0mica de teixits liderat per Xavier Trepat, primer com a post-doctorant i m\u00e9s tard com a membre Juan de la Cierva. Vito ara t\u00e9 una beca Ram\u00f3n i Cajal i \u00e9s l'investigador principal del grup Mec\u00e0nica del desenvolupament i la malaltia, la intenci\u00f3 de la qual \u00e9s desenvolupar noves eines biof\u00edsiques per quantificar la mec\u00e0nica de les c\u00e8l\u00b7lules i teixits en entorns 3D. "Amb una gran experi\u00e8ncia en l'estudi de com la mec\u00e0nica de les c\u00e8l\u00b7lules i teixits determinen l'estructura i funci\u00f3 durant el meu temps com post-doctorant, vull continuar explorant els mecanismes f\u00edsics del desenvolupament i de la malaltia en els organismes biol\u00f2gics", diu Vito, qui va completar el seu doctorat en enginyeria biomec\u00e0nica en el Kings College de Londres en el grup del Prof. Marcos Miodownik, ara director de l'Institut de Fabricaci\u00f3 en la UCL. "Per fer aix\u00f2, el meu grup va a desenvolupar noves eines per dur a terme mesuraments mec\u00e0nics in vivo i in vitro, amb les quals anem a integrar en models 2D i 3D dels organismes biol\u00f2gics estudiats."\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/el-nou-investigador-principal-de-libec-vito-conte\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2016-02-15T07:35:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-03T09:24:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/02\/vitoconte.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-investigador-principal-de-libec-vito-conte\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-investigador-principal-de-libec-vito-conte\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"El nou investigador principal de l’IBEC: Vito Conte\",\"datePublished\":\"2016-02-15T07:35:16+00:00\",\"dateModified\":\"2022-01-03T09:24:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-investigador-principal-de-libec-vito-conte\\\/\"},\"wordCount\":575,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-investigador-principal-de-libec-vito-conte\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2016\\\/02\\\/vitoconte.jpg\",\"keywords\":[\"Vito Conte\"],\"articleSection\":[\"Not\u00edcies institucionals\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-investigador-principal-de-libec-vito-conte\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-investigador-principal-de-libec-vito-conte\\\/\",\"name\":\"El nou investigador principal de l'IBEC: Vito Conte - 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