{"id":21639,"date":"2016-02-11T10:55:27","date_gmt":"2016-02-11T09:55:27","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=21639"},"modified":"2016-06-20T15:25:35","modified_gmt":"2016-06-20T13:25:35","slug":"jugant-amb-lego-molecular-per-construir-la-propera-generacio-de-vectors-administradors-de-farmacs","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/jugant-amb-lego-molecular-per-construir-la-propera-generacio-de-vectors-administradors-de-farmacs\/","title":{"rendered":"Jugant amb Lego molecular per construir la propera generaci\u00f3 de vectors administradors de f\u00e0rmacs"},"content":{"rendered":"

“Ens centrem en pol\u00edmers supramoleculars, una fam\u00edlia emergent d’estructures nanom\u00e8triques amb molts usos potencials en la qu\u00edmica de materials i medicaments, a fi de preparar-los”, diu Lorenzo. “En general, les nanopart\u00edcules que s’estan desenvolupant per a l’administraci\u00f3 de f\u00e0rmacs s\u00f3n esf\u00e8riques, per\u00f2 les nostres part\u00edcules s\u00f3n en forma de fibra.”<\/p>\n

Un d’aquests pol\u00edmers, el BTA, \u00e9s un bloc de construcci\u00f3 vers\u00e0til capa\u00e7 d’acte-assemblar-se en agregats unidimensionals en aigua. Aquesta t\u00e8cnica pot explotar l’enfocament modular \u00fanic de la qu\u00edmica supramolecular, els investigadors van poder muntar pol\u00edmers BTA neutres i amb c\u00e0rrega positiva i aix\u00ed controlar les propietats globals del pol\u00edmer mitjan\u00e7ant una simple mescla de mon\u00f2mers – mol\u00e8cules que s’uneixen qu\u00edmicament a unes altres.<\/p>\n

“Aquesta modularitat \u00fanica significa b\u00e0sicament que disposem d’una biblioteca de blocs de construcci\u00f3 – una mica com una galleda gran plena de maons de Llec de diferents colors – i podem combinar-los simplement barrejant els que ens agraden en un mateix vial”, explica Lorenzo. “Aix\u00f2 \u00e9s possible a causa que els maons s’auto-assemblen, significa que espont\u00e0niament s’uneixen per formar la fibra. Per exemple, si es tira en el vial un 50% de maons “vermells” i l’altre 50% de maons “verds”, trobarem aquests maons formant part de la fibra sense cap esfor\u00e7, ja que el material es construeix a si mateix. Els diferents maons poden tenir diferents propietats qu\u00edmiques (per exemple) o funcionalitats de c\u00e0rrega diferents (per exemple, f\u00e0rmacs o agents d’orientaci\u00f3). D’aquesta manera, podem tractar una gran quantitat de combinacions de maons, i comprovar quin funciona millor per al lliurament del f\u00e0rmac”<\/p>\n

Les propietats especials dels pol\u00edmers supramoleculars tamb\u00e9 impliquen que els pol\u00edmers poden portar m\u00e9s d’un tipus de f\u00e0rmac. “Els pol\u00edmers BTA contenen dos compartiments que poden ser usats per al subministrament intracel\u00b7lular,” afegeix Lorenzo. “Compostos hidr\u00f2fobs petits poden ser encapsulats en el nucli lip\u00f2fil, mentre que siRNA pot ser condensat en l’exterior a trav\u00e9s d’interaccions electrost\u00e0tiques.”<\/p>\n

Els cient\u00edfics van demostrar que tant el siRNA i la mol\u00e8cula hidr\u00f2foba van ser lliurats amb \u00e8xit a les c\u00e8l\u00b7lules vives. Amb l’adequaci\u00f3 de la plataforma BATI supramolecular per al lliurament intracel\u00b7lular es confirma, l’estudi representa un pas important en la cerca per desenvolupar, portadors de f\u00e0rmacs, efica\u00e7os adaptats no t\u00f2xics, i aplana el cam\u00ed per a futures recerques.<\/p>\n

—<\/p>\n

Maarten H. Bakker, Cameron C. Lee, E.W. Meijer, Patricia Y.W. Dankers and Lorenzo Albertazzi (2016). \u201cMulticomponent Supramolecular Polymers as a Modular Platform for Intracellular Delivery\u201d<\/a>. ACS Nano<\/em>, 10<\/span> (2), pp 1845\u20131852<\/p>\n","protected":false},"excerpt":{"rendered":"

\"albertazzi<\/a>El potencial terap\u00e8utic de molts f\u00e0rmacs es veu entorpit perqu\u00e8 els ronyons ho eliminen massa r\u00e0pidament, tenen propietats indesitjables, no s\u00f3n selectius o no entren correctament a l’interior cel\u00b7lular.<\/h3>\n

Ara, el nou investigador principal j\u00fanior de l’IBEC, Lorenzo Albertazzi, i els seus excompanys de la Universitat de Tecnologia d’Eindhoven, que treballen juntament amb Novartis, un soci en la ind\u00fastria, han fet un salt en l’\u00e0mbit dels vectors administradors de f\u00e0rmacs mitjan\u00e7ant el desenvolupament d’un nou tipus de vehicle amb algunes millores innovadores.<\/p>\n","protected":false},"author":4,"featured_media":21585,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-21639","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nJugant amb Lego molecular per construir la propera generaci\u00f3 de vectors administradors de f\u00e0rmacs - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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