{"id":22763,"date":"2016-05-09T07:33:13","date_gmt":"2016-05-09T07:33:13","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=22763"},"modified":"2016-05-19T13:34:51","modified_gmt":"2016-05-19T13:34:51","slug":"com-evitar-que-els-bacteris-se-sentin-com-a-casa","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/com-evitar-que-els-bacteris-se-sentin-com-a-casa\/","title":{"rendered":"Com evitar que els bacteris se sentin com a casa"},"content":{"rendered":"
Peu de foto: Observacions per microscopia confocal de biofilms estructurats de P. aeruginosa PAO1 de tipus salvatge, i els ceps mutats per a cadascuna de les diferents classes de RNR (MTS102, MTS103 i MTS125). En el costat esquerre, es mostra un esquema de l\u2019estructura longitudinal d\u2019una biopel\u00b7l\u00edcula de P. aeruginosa, mostrant-se la concentraci\u00f3 d\u2019oxigen al llarg de la biopel\u00b7l\u00edcula (Stewart i Franklin, 2008). A la dreta, es mostren imatges preses de la regi\u00f3 aer\u00f2bica de la biopel\u00b7l\u00edcula (a dalt la part superficial de la biopel\u00b7l\u00edcula) i de la regi\u00f3 anaer\u00f2bica (part inferior, la m\u00e9s profunda en l\u2019estructura de la pel\u00b7l\u00edcula).<\/h6>\n

Aquesta biopel\u00b7l\u00edcula no solament facilita la comunicaci\u00f3 de c\u00e8l\u00b7lula a c\u00e8l\u00b7lula entre els bacteris, tamb\u00e9 permet que la infecci\u00f3 augmenti i prosperi, incrementant les possibilitats de desenvolupar noves resist\u00e8ncies als antibi\u00f2tics i escapar al sistema immune del nostre cos.<\/p>\n

Com la concentraci\u00f3 d\u2019oxigen en la biopel\u00b7l\u00edcula \u00e9s un par\u00e0metre crucial per al creixement dels bacteris, i en les capes inferiors d\u2019una biopel\u00b7l\u00edcula madura es redueix la concentraci\u00f3 d\u2019oxigen provocant unes condicions anaer\u00f2biques estrictes (sense oxigen) en el seu interior, els investigadors de l\u2019IBEC, van analitzar l\u2019efecte de l\u2019oxigen sobre els tres tipus diferents de l\u2019enzim ribonucle\u00f2tid reductasa (RNR) del bacteri P. aeruginosa<\/em>, fonamental per subministrar els precursors necessaris per a la s\u00edntesi i reparaci\u00f3 de l\u2019ADN.<\/p>\n

\u201cP. aeruginosa<\/em> \u00e9s un dels pocs bacteris que codifiquen per a les tres classes de RNR conegudes: classe I, la que \u00e9s dependent de l\u2019oxigen, classe II, la que \u00e9s independent de l\u2019oxigen, i classe III, la que \u00e9s sensible a l\u2019oxigen i solament pot funcionar en condicions anaer\u00f2biques estrictes\u201d, explica Eduard Torrents, investigador principal del IBEC que va dur a terme l\u2019estudi. \u201cAquestes RNR s\u00f3n les responsables d\u2019augmentar la capacitat d\u2019aquest bacteri per cr\u00e9ixer en els diferents entorns aer\u00f2bics i anaer\u00f2bic generats al llarg de les biopel\u00b7l\u00edcules\u201d.<\/p>\n

Els cient\u00edfics van modelar una biopel\u00b7l\u00edcula de P. aeruginosa<\/em> com un conjunt de capes amb diferents perfils d\u2019expressi\u00f3 de RNR. \u201cHem trobat que els bacteris tenien dificultats de formar una biopel\u00b7l\u00edcula quan faltaven les RNR de classe II i III -la classe independent i la sensible a l\u2019oxigen-\u201d, explica Anna Crespo, primera autora de l\u2019article. \u201cLes RNR de classes II i III s\u00f3n clarament essencials per al creixement anaer\u00f2bic i, sense elles, les biopel\u00b7l\u00edcules totalment madures no poden establir-se\u201d.<\/p>\n

Les seves troballes porten als investigadors a apropar-se a comprendre aquest complex patr\u00f3 de creixement dels bacteris, sobretot en infeccions pulmonars cr\u00f2niques on juguen un paper molt important. Entendre la virul\u00e8ncia de les biopel\u00b7l\u00edcules bacterianes ajudar\u00e0 a millorar el disseny de f\u00e0rmacs antibacterians espec\u00edfics.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia: <\/strong>Anna Crespo, Lucas Pedraz, Josep Astola, Eduard Torrents (2016). Pseudomonas aeruginosa<\/em> exhibits deficient biofilm formation in the absence of class II and III ribonucleotide reductases due to hindered anaerobic growth.<\/a> Frontiers in Microbiology<\/em> 7:688. doi: 10.3389\/fmicb.2016.00688.<\/p>\n

—<\/p>\n

IBEC in the media:<\/strong><\/p>\n

La Vanguardia, “Investigadores abren nuevas v\u00edas para mejorar los f\u00e1rmacos antibacterianos”
\n<\/a>NCYT, “C\u00f3mo evitar que las bacterias se sientan como en casa”
\n<\/a>Gaceta M\u00e9dica, “RNRII y III son clave para que las bacterias formen la biopel\u00edcula”
\n<\/a>Agencia SINC, “C\u00f3mo evitar que las bacterias se sientan como en casa”
\n<\/a>F\u00e1rmaco Salud, “C\u00f3mo evitar que las bacterias se sienta como en casa”<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"torrentsFig2_web\"<\/a>Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) estan m\u00e9s a prop de comprendre com els bacteris provoquen infeccions cr\u00f2niques mitjan\u00e7ant la identificaci\u00f3 dels enzims clau que els permeten crear les condicions adequades per a la infecci\u00f3 en forma de biopel\u00b7l\u00edcula, la qual cosa ajudar\u00e0 a millorar el disseny de f\u00e0rmacs antibacterians espec\u00edfics.<\/h3>\n

Quan els bacteris P. aeruginosa<\/em> provoquen infeccions cr\u00f2niques de pulm\u00f3, com per exemple en pacients de Fibrosi Qu\u00edstica o de Malaltia Pulmonar Obstructiva Cr\u00f2nica (EPOC), significa que han estat capaces de formar una biopel\u00b7l\u00edcula madura in situ que els permet cr\u00e9ixer i adaptar-se. <\/p>\n","protected":false},"author":4,"featured_media":22744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-22763","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nCom evitar que els bacteris se sentin com a casa - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/com-evitar-que-els-bacteris-se-sentin-com-a-casa\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Com evitar que els bacteris se sentin com a casa - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) estan m\u00e9s a prop de comprendre com els bacteris provoquen infeccions cr\u00f2niques mitjan\u00e7ant la identificaci\u00f3 dels enzims clau que els permeten crear les condicions adequades per a la infecci\u00f3 en forma de biopel\u00b7l\u00edcula, la qual cosa ajudar\u00e0 a millorar el disseny de f\u00e0rmacs antibacterians espec\u00edfics. 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