{"id":22798,"date":"2016-05-12T12:51:26","date_gmt":"2016-05-12T12:51:26","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=22798"},"modified":"2016-05-19T13:13:58","modified_gmt":"2016-05-19T13:13:58","slug":"el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\/","title":{"rendered":"El seguiment de la virul\u00e8ncia bacteriana: moduladors globals com a indicadors"},"content":{"rendered":"<p>Els tipus d&#8217;<em>E. coli<\/em> virulents com aquest es classifiquen en patotips, que es defineixen per una combinaci\u00f3 de factors de virul\u00e8ncia (mol\u00e8cules produ\u00efdes pels bacteris que contribueixen a la seva patogenicitat), fenotip, i les associacions cl\u00edniques. Una bona part dels patotips d&#8217;<em>E. coli<\/em> ja s&#8217;identifiquen i caracteritzen gr\u00e0cies a l&#8217;estudi de la distribuci\u00f3 dels gens de virul\u00e8ncia en les soques a\u00efllades dels pacients infectats. No obstant aix\u00f2, el fenotip de virul\u00e8ncia no est\u00e0 associat estrictament a cada patotip; \u00e9s a dir, un mateix patotip pot ser m\u00e9s o menys virulent en funci\u00f3 de la soca i el serotip, presentant diferents factors de virul\u00e8ncia.<\/p>\n<p>A l&#8217;article publicat avui en Scientific Reports, els investigadors de l&#8217;IBEC, la Universitat de Barcelona, la Universidade de Santiago de Compostel\u00b7la i l&#8217;Institut de Microbiologia M\u00e8dica i DZIF d&#8217;Alemanya van examinar la correlaci\u00f3 entre la pres\u00e8ncia de certs gens i el fenotip de virul\u00e8ncia de les soques pat\u00f2genes d&#8217;<em>E. coli<\/em>. Els investigadors van trobar que els genomes de diverses soques de pat\u00f2genes intestinals enteroagregatives d&#8217;<em>E. coli<\/em> alberguen dues variants d&#8217;un mateix gen que codifica per a un modulador global (el gen hha). Aquestes variants, denominades hha2 i hha3, predominen en els a\u00efllaments d&#8217;<em>E. coli<\/em> de pacients infectats i que s\u00f3n productors de toxines Shiga, com ocorre en la soca altament virulenta O104:H4. Les variants hha2 i hha3 tamb\u00e9 predominen en les soques d&#8217;<em>E. coli<\/em> tipus ST131, que s\u00f3n resistents als antibi\u00f2tics, provoquen infeccions extraintestinals i s\u00f3n de distribuci\u00f3 mundial.<\/p>\n<p>&#8220;Hem posat de manifest que la detecci\u00f3 d&#8217;aquests tipus de prote\u00efnes i dels seus gens pot ser una nova estrat\u00e8gia per identificar els serotips pat\u00f2gens bacterians&#8221;, diu Antonio Ju\u00e1rez de l&#8217;IBEC \/ UB, qui ha dirigit l&#8217;estudi. &#8220;En el cas d&#8217;<em>E. coli<\/em>, si som capa\u00e7os d&#8217;amplificar les variants hha2 i hha3 i establir-les com a indicadors de la virul\u00e8ncia de les soques d&#8217;<em>E. coli<\/em> a\u00efllades del medi ambient i dels pacients, podrem detectar f\u00e0cilment les variants pat\u00f2genes, podent aix\u00ed prevenir millor els brots infecciosos&#8221;.<br \/>\n&#8212;<\/p>\n<p><em><strong>Article referenciat:<\/strong> <\/em>Alejandro Prieto, Imanol Urcola, Jorge Blanco, Ghizlane Dahbi, Maria Teresa Muniesa, Pablo Quir\u00f3s, Linda Falgenhauer, Trinad Chakraborty, M\u00e1rio H\u00fcttener and Antonio Ju\u00e1rez (2016). <a href=\"http:\/\/www.nature.com\/articles\/srep25973\">Tracking bacterial virulence: global modulators as indicators.<\/a> <em>Sci Rep<\/em> 6, Article number: 25973<\/p>\n<p>&#8212;<\/p>\n<p><strong>IBEC in the media:<\/strong><br \/>\nLa Vanguardia, <a href=\"http:\/\/www.lavanguardia.com\/vida\/20160517\/401856489145\/un-nuevo-marcador-de-virulencia-bacteriana-puede-prevenir-brotes-infecciosos.html\" target=\"_blank\">&#8220;Un nuevo marcador de virulencia bacgeriana puede prevenir brotes infecciosos&#8221;<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/05\/E._coli_Bacteria_fromNIAIDweb.jpg\" alt=\"\" width=\"400\" height=\"289\" class=\"left size-full wp-image-22790 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/05\/E._coli_Bacteria_fromNIAIDweb.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/05\/E._coli_Bacteria_fromNIAIDweb-300x217.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/05\/E._coli_Bacteria_fromNIAIDweb-180x130.jpg 180w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/05\/E._coli_Bacteria_fromNIAIDweb-150x108.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/289;\" \/><\/a>Investigadors de la Universitat de Barcelona (UB) i de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC) juntament amb els seus col\u00b7laboradors han definit un nou tipus de marcadors de virul\u00e8ncia bacteriana que poden ajudar a detectar i prevenir els brots d&#8217;infeccions provocats per <em>Escherichia coli<\/em>. <\/h3>\n<p>La majoria de les soques bacterianes d&#8217; <em>E. coli<\/em>, es troben de forma natural en l&#8217;intest\u00ed hum\u00e0 i no suposen cap risc per a la salut, a excepci\u00f3 de determinats tipus d&#8217;aquests bacteris (patotip), alguns dels quals causen intoxicacions aliment\u00e0ries que pot arribar a ser mortals. Una d&#8217;aquestes soques virulentes d&#8217;<em>E. coli<\/em>, el serotip O104: H4, va causar un important brot infecci\u00f3s a Alemanya durant l&#8217;any 2011, associat a una alta prevalen\u00e7a de la s\u00edndrome hemol\u00edtic-ur\u00e8mic. Es tractava d&#8217;una soca d&#8217;evoluci\u00f3 recent que va fer que es registr\u00e9s l&#8217;\u00edndex m\u00e9s gran de mortaldat per <em>E. coli<\/em> de tots els temps.<\/p>\n","protected":false},"author":4,"featured_media":22792,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-22798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>El seguiment de la virul\u00e8ncia bacteriana: moduladors globals com a indicadors - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El seguiment de la virul\u00e8ncia bacteriana: moduladors globals com a indicadors - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de la Universitat de Barcelona (UB) i de l&#039;Institut de Bioenginyeria de Catalunya (IBEC) juntament amb els seus col\u00b7laboradors han definit un nou tipus de marcadors de virul\u00e8ncia bacteriana que poden ajudar a detectar i prevenir els brots d&#039;infeccions provocats per Escherichia coli.   La majoria de les soques bacterianes d&#039; E. coli, es troben de forma natural en l&#039;intest\u00ed hum\u00e0 i no suposen cap risc per a la salut, a excepci\u00f3 de determinats tipus d&#039;aquests bacteris (patotip), alguns dels quals causen intoxicacions aliment\u00e0ries que pot arribar a ser mortals. Una d&#039;aquestes soques virulentes d&#039;E. coli, el serotip O104: H4, va causar un important brot infecci\u00f3s a Alemanya durant l&#039;any 2011, associat a una alta prevalen\u00e7a de la s\u00edndrome hemol\u00edtic-ur\u00e8mic. Es tractava d&#039;una soca d&#039;evoluci\u00f3 recent que va fer que es registr\u00e9s l&#039;\u00edndex m\u00e9s gran de mortaldat per E. coli de tots els temps.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2016-05-12T12:51:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2016-05-19T13:13:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/05\/E._coli_Bacteria_fromNIAIDweb.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"289\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"El seguiment de la virul\u00e8ncia bacteriana: moduladors globals com a indicadors\",\"datePublished\":\"2016-05-12T12:51:26+00:00\",\"dateModified\":\"2016-05-19T13:13:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\\\/\"},\"wordCount\":425,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2016\\\/05\\\/E._coli_Bacteria_fromNIAIDweb.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-seguiment-de-la-virulencia-bacteriana-moduladors-globals-com-a-indicadors\\\/\",\"name\":\"El seguiment de la virul\u00e8ncia bacteriana: moduladors globals com a indicadors - 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