{"id":22849,"date":"2016-05-17T07:44:45","date_gmt":"2016-05-17T07:44:45","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=22849"},"modified":"2016-05-23T12:12:35","modified_gmt":"2016-05-23T12:12:35","slug":"buscant-la-solucio-per-a-la-malaria-en-el-fons-mari","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/buscant-la-solucio-per-a-la-malaria-en-el-fons-mari\/","title":{"rendered":"Buscant la soluci\u00f3 per a la mal\u00e0ria en el fons mar\u00ed"},"content":{"rendered":"

Des de fa temps se sap que algunes biomol\u00e8cules com l’heparina poden bloquejar l’adhesi\u00f3 i entrada dels merozo\u00efts als gl\u00f2buls vermells; no obstant aix\u00f2, l’heparina no \u00e9s un bon candidat terap\u00e8utic a causa que les quantitats necess\u00e0ries per al tractament de la mal\u00e0ria podrien provocar hemorr\u00e0gies internes.<\/p>\n

En un estudi publicat en la revista Scientifc Reports, els autors van explorar la capacitat antimal\u00e0rica de polisac\u00e0rids sulfatats semblats a l’heparina, derivats de cogombres de mar, algues vermelles i esponges marines, i van trobar que aquests compostos inhibeixen de manera significativa el creixement de P. falciparum, encara que es trobi a concentracions baixes a les quals aquestes mol\u00e8cules no tenen activitat anticoagulant. A m\u00e9s, la majoria dels compostos analitzats van augmentar la superviv\u00e8ncia de ratolins infectats amb una altra esp\u00e8cie de Plasmodium i, fins i tot en algun dels ratolins infectats, van observar l’aparici\u00f3 d’anticossos contra el par\u00e0sit, la qual cosa suggereix que el fet de retardar la invasi\u00f3 dels gl\u00f2buls vermells afavoreix la generaci\u00f3 d’una resposta immune contra el par\u00e0sit.<\/p>\n

“Els organismes marins s\u00f3n una font rica en polisac\u00e0rids sulfatats similars a l’heparina”, diu Joana Marquis, investigadora de la unitat mixta IBEC\/ISGlobal i primera autora de l’article. “L’avantatge \u00e9s que aquestes mol\u00e8cules tenen activitats anticoagulants suficientment petites per ser utilitzades en la sang circulant a les seves concentracions actives sense inc\u00f3rrer en el risc d’hemorr\u00e0gia interna”.<\/p>\n

“En els experiments in vitro que hem fet amb tots aquests compostos es va demostrar una inhibici\u00f3 significativa del creixement del Plasmodium falciparum, fins i tot a baixes activitats anticoagulants, i els assajos preliminars in vivo en ratolins s\u00f3n prometedors”, diu Xavier Fern\u00e1ndez-Busquets, responsable de la unitat mixta IBEC\/ISGlobal. “Aquests compostos alenteixen la invasi\u00f3 dels gl\u00f2buls vermells per Plasmodium, i tal vegada la resultant exposici\u00f3 perllongada del par\u00e0sit als limf\u00f2cits circulants d\u00f3na al sistema immunitari una major oportunitat de construir defenses”.<\/p>\n

El seu descobriment implica que les mol\u00e8cules relacionades amb l’heparina es poden considerar i explorar per al disseny de nous enfocaments terap\u00e8utics contra la mal\u00e0ria en els quals els polisac\u00e0rids amb baixa activitat anticoagulant podrien exercir un doble paper; com a f\u00e0rmacs inhibint el creixement del par\u00e0sit i, alhora, promovent la resposta immune contra el mateix.<\/p>\n

En aquest estudi tamb\u00e9 han participat l’Institut de Nanociencia i Nanotecnologia de Barcelona (IN2UB) i la Universidade Federal do Rio de Janeiro.<\/p>\n

Xavier Fern\u00e1ndez-Busquets donar\u00e0 un seminari, A Short (Hi)story of Malaria<\/a>, a l’IBEC el divendres 20 de maig a les 10:00h.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/strong><\/em> Joana Marques, Eduardo Vilanova, Paulo A. S. Mour\u00e3o and Xavier Fern\u00e0ndez-Busquets (2016). Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by <\/a>Plasmodium. <\/a>Sci Rep\u00a0<\/em>6, Article\u00a0number:\u00a024368<\/p>\n

—<\/p>\n

IBEC in the media:<\/strong>
\nLa Vanguardia, “Descubren una posible soluci\u00f3n para la malaria en el fondo marino”<\/a>
\nAgencia SINC, “La soluci\u00f3n para la malaria podr\u00eda estar en el fondo marino”<\/a>
\nTe interesa, “Investigadores descubren una posible soluci\u00f3n para la malaria en el fondo marino”<\/a>
\nLa Vanguardia (Big Vang), “Pepinos, algas y esponjas marinas para curar la malaria”<\/a>
\nEcodiario, “Investigadores descubren una posible soluci\u00f3n para la malaria en el fondo marino”<\/a>
\nEcoticias, “Los fondos marinos podr\u00edan curar la malaria”<\/a>
\nNCYT, “Buscando soluci\u00f3n para la malaria en el fondo marino”
\n<\/a>Diario M\u00e9dico, “Hallan propiedades antimal\u00e1ricas en az\u00facares derivados de organismos marinos”<\/a>
\nGaceta M\u00e9dica, “Hallan propiedades antimal\u00e1ricas en az\u00facares derivados de organismos marinos”<\/a>
\nNoticiero Universal, “La soluci\u00f3n para la malaria podr\u00eda estar en el fondo marino”<\/a>
\nDiario Siglo XXI, “Investigadores descubren una posible soluci\u00f3n para la malaria en el fondo marino”<\/a>
\nCatalunya Vanguardista, “Organismos marinos contra la malaria”<\/a>
\nEl Correo de Andaluc\u00eda, “Descubren una posible soluci\u00f3n para la malaria en el fondo marino”<\/a>
\nCiencia Explora, “La soluci\u00f3n para la malaria podr\u00eda estar en el fondo marino”<\/a>
\nEuropaPress, “Descobreixen una possible soluci\u00f3 per la malaria en el fons mar\u00ed”
\n<\/a>La Informaci\u00f3n, “Investigadores descubren una posible soluci\u00f3n para la malaria”<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"Microciona_forweb\"<\/a>Investigadors de la unitat mixta de Nanomalaria IBEC\/ISGlobal, han trobat mol\u00e8cules similars a l’heparina, a\u00efllades a partir de cogombres de mar, algues vermelles i esponges marines, que inhibeixen el creixement del Plasmodium falciparum, un dels par\u00e0sits causants de la mal\u00e0ria. A difer\u00e8ncia de l’heparina, aquestes mol\u00e8cules tenen una activitat redu\u00efda com a anticoagulant sanguini, la qual cosa obre noves vies per al desenvolupament de medicaments antimal\u00e0rics.<\/h3>\n

Quan el par\u00e0sit de la mal\u00e0ria entra en el torrent sanguini, envaeix les c\u00e8l\u00b7lules del fetge per produir milers de merozo\u00efts (una fase del cicle de vida del par\u00e0sit Plasmodium). Aquests merozo\u00efts tornen a incorporar-se al torrent, on infecten els gl\u00f2buls vermells i aconsegueixen escapar a la vigil\u00e0ncia del sistema immunitari.<\/p>\n","protected":false},"author":4,"featured_media":22812,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[161,162,539,158,159,157],"post_formats":[],"class_list":["post-22849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-fondo-marino-ca","tag-heparina-ca","tag-ibec-es-ca","tag-ibec-ca","tag-isglobal-ca","tag-malaria-ca"],"yoast_head":"\nBuscant la soluci\u00f3 per a la mal\u00e0ria en el fons mar\u00ed - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/buscant-la-solucio-per-a-la-malaria-en-el-fons-mari\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Buscant la soluci\u00f3 per a la mal\u00e0ria en el fons mar\u00ed - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de la unitat mixta de Nanomalaria IBEC\/ISGlobal, han trobat mol\u00e8cules similars a l'heparina, a\u00efllades a partir de cogombres de mar, algues vermelles i esponges marines, que inhibeixen el creixement del Plasmodium falciparum, un dels par\u00e0sits causants de la mal\u00e0ria. 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