{"id":22969,"date":"2016-05-19T13:12:39","date_gmt":"2016-05-19T13:12:39","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=22969"},"modified":"2016-05-23T07:57:53","modified_gmt":"2016-05-23T07:57:53","slug":"investigadors-generen-empelts-de-cor-funcionals-a-partir-de-cel%c2%b7lules-mare-pluripotentes-humanes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-generen-empelts-de-cor-funcionals-a-partir-de-cel%c2%b7lules-mare-pluripotentes-humanes\/","title":{"rendered":"Investigadors generen empelts de cor funcionals a partir de c\u00e8l\u00b7lules mare pluripotentes humanes"},"content":{"rendered":"
Imatge: Diferenciaci\u00f3 card\u00edaca de c\u00e8l\u00b7lules mare pluripotents humanes derivades a cardiomiocits en la matriu extracel\u00b7lular d’un ventricle descel\u00b7lularitzat<\/h6>\n

Les c\u00e8l\u00b7lules dins de la matriu descel\u00b7lularitzada de cor hum\u00e0 van mostrar un major grau de diferenciaci\u00f3 card\u00edaca fisiol\u00f2gica i molecular en comparaci\u00f3 de les c\u00e8l\u00b7lules conreades en plaques de cultiu de teixit, que ha estat el m\u00e8tode utilitzat fins ara. En tan sols 24 dies els empelts card\u00edacs humans ja presentaven les respostes electrofisiol\u00f2giques necess\u00e0ries per desenvolupar una funci\u00f3 card\u00edaca correcta, \u00e9s a dir, bombaven d’una manera similar al del cor.<\/p>\n

\"Imatge:<\/a>
Cardiomyocyte-like cells derived from human pluripotent stem cells<\/figcaption><\/figure>\n

Aquest tipus de des- i recel\u00b7lularitzaci\u00f3 d’\u00f2rgans representa una estrat\u00e8gia prometedora per al desenvolupament d’\u00f2rgans biofuncionals que es poden ser utilitzats per a la detecci\u00f3 de drogues i el desenvolupament de la medicina personalitzada.<\/p>\n

“La descel\u00b7lularitzaci\u00f3 de tot un cor implica centenars de seccions acel\u00b7lulars llistes per utilitzar-se com a bastides”, diu la N\u00faria Montserrat des del IBEC, una dels tres autors principals de l’article cient\u00edfic. “Anticipem que el nostre procediment r\u00e0pid pot ser aplicat immediatament en els laboratoris per a l’enginyeria card\u00edaca i el modelatge de malalties aplicat als \u00e9ssers humans.”<\/p>\n

L’estudi en el qual han participat investigadors de l’IBEC i de l’Hospital General Universitari Gregorio Mara\u00f1\u00f3n d’Espanya, aix\u00ed com la Universitat de Minnesota, el Texas Heart Institute i el Salk Institute for Biological Studies en els EUA, va ser finan\u00e7at en part per una subvenci\u00f3 European Research Council.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/em> <\/strong>Elena Garreta, Lorena de O\u00f1ate, M. Eugenia Fern\u00e1ndez-Santos, Roger Oria, Carolina Tarantino, Andreu M. Climent, Andr\u00e9s Marco, Mireia Samitier, Elena Mart\u00ednez, Maria Valls-Margarit, Rafael Matesanz, Doris A. Taylor, Francisco Fern\u00e1ndez-Avil\u00e9s, Juan Carlos Izpisua Belmonte & Nuria Montserrat (2016). Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts.<\/a> Biomaterials<\/em>, 98, 64-78<\/p>\n

—<\/p>\n

IBEC in the media:<\/strong><\/em>
\nLa Vanguardia, “Crean injertos de coraz\u00f3n a partir de c\u00e9lulas madre en menos de un mes”<\/a>
\nLa Raz\u00f3n, “Crean injertos de coraz\u00f3n con c\u00e9lulas madre”<\/a>
\nDiario M\u00e9dico, “Crean injertos de coraz\u00f3n a partir de c\u00e9lulas madre”
\n<\/a>Agencia SINC, “Injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre pluripotentes humanas”<\/a>
\nHuelva Informaci\u00f3n, “Injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre”<\/a>
\nEl D\u00eda de C\u00f3rdoba,\u00a0“Injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre”<\/a>
\nM\u00e1laga Hoy,\u00a0“Injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre”<\/a>
\nDiario de C\u00e1diz,\u00a0“Injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre”<\/a>
\nDiaro de Sevilla,\u00a0“Injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre”<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"Foto2\"Investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb l’Hospital General Universitari Gregorio Mara\u00f1\u00f3n i dos grups dels EUA han creat, per primera vegada, empelts de cor a partir de c\u00e8l\u00b7lules mare pluripotents humanes en un per\u00edode inferior a un mes.<\/h3>\n

L’estudi, publicat recentment en la revista Biomaterials, descriu com els investigadors han descel\u00b7lularitzat cors humans qualificats com “no aptes per al trasplantament” per l’Organitzaci\u00f3 Nacional de Trasplantaments, deixant la matriu extracel\u00b7lular intacta i lliure de c\u00e8l\u00b7lules, i a continuaci\u00f3, l’han repoblat amb c\u00e8l\u00b7lules card\u00edaques obtingudes a partir de t\u00e8cniques d’edici\u00f3 del genoma en c\u00e8l\u00b7lules mares pluripotents humanes (hPSCs) (c\u00e8l\u00b7lules no diferenciades, a partir de les quals es poden desenvolupar altres tipus cel\u00b7lulars). Les c\u00e8l\u00b7lules mare pluripotents s\u00f3n crucials per a aquest proc\u00e9s, ja que el cos no \u00e9s capa\u00e7 de generar noves c\u00e8l\u00b7lules card\u00edaques despr\u00e9s d’un atac al cor o un altre tipus de dany card\u00edac.<\/p>\n","protected":false},"author":4,"featured_media":22880,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-22969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nInvestigadors generen empelts de cor funcionals a partir de c\u00e8l\u00b7lules mare pluripotentes humanes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-generen-empelts-de-cor-funcionals-a-partir-de-cel\u00b7lules-mare-pluripotentes-humanes\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors generen empelts de cor funcionals a partir de c\u00e8l\u00b7lules mare pluripotentes humanes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb l'Hospital General Universitari Gregorio Mara\u00f1\u00f3n i dos grups dels EUA han creat, per primera vegada, empelts de cor a partir de c\u00e8l\u00b7lules mare pluripotents humanes en un per\u00edode inferior a un mes. 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