{"id":24733,"date":"2016-09-28T17:30:13","date_gmt":"2016-09-28T15:30:13","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=24733"},"modified":"2016-09-29T13:10:22","modified_gmt":"2016-09-29T11:10:22","slug":"noves-estrategies-per-combatre-la-malaria-heparina-i-nanomedicina","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/noves-estrategies-per-combatre-la-malaria-heparina-i-nanomedicina\/","title":{"rendered":"Noves estrat\u00e8gies per combatre la mal\u00e0ria: heparina i nanomedicina"},"content":{"rendered":"

\"dr-xavier-fernandez-busquets-2\"<\/p>\n

Des de fa diverses d\u00e8cades se sap que quan el par\u00e0sit de la mal\u00e0ria entra en el torrent sanguini, envaeix les c\u00e8l\u00b7lules del fetge per produir milers de merozo\u00efts\u00a0(una fase de vida del par\u00e0sit) que tornen a incorporar-se a la circulaci\u00f3, on infecten els gl\u00f2buls vermells i aconsegueixen escapar a la vigil\u00e0ncia del sistema immunitari. \u201cEl nostre primer pas va ser demostrar que l’heparina pot bloquejar l’adhesi\u00f3 i entrada delsmerozo\u00efts als gl\u00f2buls vermells. Aix\u00ed, inhibint el creixement del par\u00e0sit, es podria promoure la resposta immune contra el mateix\u201d, ha explicat el Dr. Fern\u00e1ndez-Busquets aquest mat\u00ed.<\/p>\n

A m\u00e9s, el grup del Dr. Fern\u00e1ndez Busquets va descobrir que l’heparina mostra afinitat d’uni\u00f3 espec\u00edfica per als gl\u00f2buls vermells infectats enfront dels gl\u00f2buls no infectats. \u201cAix\u00f2 podria permetre el desenvolupament de ter\u00e0pies antimal\u00e1ricas espec\u00edfiques per a les c\u00e8l\u00b7lules infectades, basades tamb\u00e9 en l’heparina\u201d afegeix.<\/p>\n

Fins ara, l’heparina no havia progressat cap a aquest tipus d’aplicacions cl\u00edniques perqu\u00e8 presenta una forta activitat anticoagulant i les quantitats necess\u00e0ries per al tractament contra la mal\u00e0ria podria provocar hemorr\u00e0gies internes. Per solucionar aquest problema s’investiga per tres vies diferents:<\/p>\n

D’una banda s’ha vist que la uni\u00f3 de nanopart\u00edcules a l’heparina minimitza la seva activitat anticoagulant. Ara s’est\u00e0 explorant la capacitat de l’heparina unida a nanopart\u00edcules per exercir una doble activitat: com a agent transportador d’altres antimal\u00e0rics (que estarien inclosos en les nanopart\u00edcules) i com a f\u00e0rmac en si mateix.<\/p>\n

En segon lloc s’estudia l’\u00fas de l’heparina com a f\u00e0rmac contra les fases del par\u00e0sit de la mal\u00e0ria que es troben en els mosquits; l’administraci\u00f3 directa a aquests insectes eliminaria els problemes relacionats amb la anticoagulaci\u00f3 i permetria un desenvolupament r\u00e0pid del compost.<\/p>\n

Finalment, s’estan testant in vitro 19 compostos derivats d’heparina modificats qu\u00edmicament i amb una baixa capacitat anticoagulant, que podrien obrir noves estrat\u00e8gies contra la mal\u00e0ria basades en l’estimulaci\u00f3 del sistema immunitari perqu\u00e8 pugui eliminar m\u00e9s eficientment al patogen. D’aquests, 8 han mostrat una activitat antimal\u00e0rica significativa.<\/p>\n

\u201cHem finalitzat una primera fase molt interessant. Les tres s\u00f3n estrat\u00e8gies que obren la porta a dissenyar nous enfocaments terap\u00e8utics contra la mal\u00e0ria i aix\u00f2 ens anima a seguir investigant\u201d, conclou Fern\u00e1ndez Busquets.<\/p>\n","protected":false},"excerpt":{"rendered":"

L’Institut de Bioenginyeria de Catalunya (IBEC), l’Institut de Salut Global de Barcelona (ISGlobal)<\/a> y la companyia biotecnol\u00f2gica Bioib\u00e9rica<\/a> han presentat avui en roda de premsa, un acord de col\u00b7laboraci\u00f3 per estudiar el desenvolupament de nous compostos derivats d’heparina per combatre la mal\u00e0ria. <\/h3>\n

La col\u00b7laboraci\u00f3, que s’ha presentat aquest mat\u00ed en el marc del Congr\u00e9s internacional Biospain (Bilbao)<\/a>, es basa en la recerca que desenvolupa el Dr. Xavier Fern\u00e1ndez Busquets -responsable de la unitat conjunta de Nanomalaria IBEC\/ISGlobal-<\/a>, que treballa per desenvolupar ter\u00e0pies antimal\u00e0riques espec\u00edfiques, i el projecte d’R+D de Bioib\u00e9rica, l\u00edder mundial en la producci\u00f3 d’heparina, per buscar noves aplicacions d’aquesta mol\u00e8cula.<\/p>\n

La mal\u00e0ria infecta cada any a 200 milions de persones i causa mig mili\u00f3 de morts a tot el m\u00f3n. <\/p>\n","protected":false},"author":4,"featured_media":24729,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[279,280,162,158,159,157],"post_formats":[],"class_list":["post-24733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-bioiberica","tag-biospain","tag-heparina-ca","tag-ibec-ca","tag-isglobal-ca","tag-malaria-ca"],"yoast_head":"\nNoves estrat\u00e8gies per combatre la mal\u00e0ria: heparina i nanomedicina - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/noves-estrategies-per-combatre-la-malaria-heparina-i-nanomedicina\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Noves estrat\u00e8gies per combatre la mal\u00e0ria: heparina i nanomedicina - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L'Institut de Bioenginyeria de Catalunya (IBEC), l'Institut de Salut Global de Barcelona (ISGlobal) y la companyia biotecnol\u00f2gica Bioib\u00e9rica han presentat avui en roda de premsa, un acord de col\u00b7laboraci\u00f3 per estudiar el desenvolupament de nous compostos derivats d'heparina per combatre la mal\u00e0ria. 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