{"id":25348,"date":"2016-10-27T15:03:42","date_gmt":"2016-10-27T13:03:42","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=25348"},"modified":"2016-10-27T15:27:00","modified_gmt":"2016-10-27T13:27:00","slug":"molecules-que-sactiven-amb-llum-per-controlar-lactivitat-dels-receptors-de-glutamat","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/molecules-que-sactiven-amb-llum-per-controlar-lactivitat-dels-receptors-de-glutamat\/","title":{"rendered":"Mol\u00e8cules que s’activen amb llum per controlar l’activitat dels receptors de glutamat"},"content":{"rendered":"

Aquest acoblament fa que el receptor s’activi o no, el que desencadena al seu torn l’activitat<\/p>\n

Un treball publicat recentment a la revista Cell Chemical Biology i liderat per Pau Gorostiza, cient\u00edfic ICREA a l’Institut de Bioenginyeria de Catalunya (IBEC), Amadeu Llebaria, de l’Institut de Qu\u00edmica Avan\u00e7ada del CSIC a Catalunya (IQAC), i Cyril Goudet, de l’Institut de Gen\u00f2mica Funcional del CNRS de Fran\u00e7a, ha presentat unes noves mol\u00e8cules d’aquest tipus.<\/p>\n

En aquest cas, els cient\u00edfics han aconseguit una mol\u00e8cula que canvia de forma en rebre llum violeta i que s’acobla al receptor de glutamat, el que fa que aquest \u00faltim disminueixi o augmenti la seva activitat. L’\u00fas controlat de la llum permetria un \u00fas localitzat i prec\u00eds d’aquesta mol\u00e8cula.<\/p>\n

Els receptors de glutamat estan implicats en les transmissions sin\u00e0ptiques del sistema nervi\u00f3s central. Estan implicats en multitud de processos, com la percepci\u00f3 del dolor, la mem\u00f2ria, o la regulaci\u00f3 motora. Igualment, l’alteraci\u00f3 de la seva activitat s’associa a diferents malalties, de manera que constitueixen punts d’acci\u00f3 interessants per al desenvolupament de f\u00e0rmacs.<\/p>\n

En un comentari publicat sobre l’article en la mateixa revista, Ferdinando Nicoletti, un expert mundial en receptors de glutamat, destaca la import\u00e0ncia i novetat de la investigaci\u00f3. A m\u00e9s, destaca el potencial dels compostos fotoactivables en la investigaci\u00f3 de f\u00e0rmacs per a malalties com el Parkinson i la seva possible aplicaci\u00f3 en tractaments localitzats en dolor.<\/p>\n

Es podria plantejar el seu \u00fas per a estudis biol\u00f2gics del sistema nervi\u00f3s central, o per avaluar mol\u00e8cules en noves ter\u00e0pies. Igualment, explica Amadeu Llebaria, es pot pensar la seva aplicaci\u00f3 en f\u00e0rmacs que actu\u00efn de manera controlada en una zona determinada del cervell i activar-amb ‘microleds’ implantables en el cos. El treball encara est\u00e0 en la fase del que anomenen prova de concepte, en la qual s’intenta demostrar si l’estrat\u00e8gia \u00e9s possible o no.<\/p>\n

Aquestes mol\u00e8cules podrien obrir la porta a un tractament personalitzat i millorat de malalties mitjan\u00e7ant un diagn\u00f2stic previ espec\u00edfic i un ajust personalitzat del f\u00e0rmac. A m\u00e9s, l’\u00fas d’aquest tipus de f\u00e0rmacs podria portar a un control prec\u00eds del lloc d’acci\u00f3 i de l’ajust de la durada dels seus efectes, en l\u00ednia amb les noves tend\u00e8ncies de la ‘medicina de precisi\u00f3’.<\/p>\n

En el treball tamb\u00e9 han participat cient\u00edfics de la Universitat Aut\u00f2noma de Barcelona i el Centre d’investigaci\u00f3 Biom\u00e8dica en xarxa CIBER-BNN.<\/p>\n

Refer\u00e8ncia<\/em><\/strong>: Xavier Rovira, Ana Trapero, Silvia Pittolo, Charleine Zussy, Ad\u00e8le Faucherre, Chris Jopling, Jes\u00fas Giraldo, Jean-Philippe Pin, Pau Gorostiza, Cyril Goudet, Amadeu Llebaria. OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity<\/a>. Cell Chemical Biology, Volume 23, Issue 8, 18 August 2016, Pages 929-934<\/p>\n","protected":false},"excerpt":{"rendered":"

\"immunoliposomes\" <\/p>\n

Investigadors de l’IBEC, IQAC-CSIC i CNRS han desenvolupat unes mol\u00e8cules que poden modular l’activitat dels receptors de glutamat en el sistema nervi\u00f3s central, amb importants aplicacions en biomedicina.<\/h3>\n

Des de fa uns pocs anys es treballa en el desenvolupament dels anomenats f\u00e0rmacs o mol\u00e8cules ‘fotoconmutadors covalents’ o TCP (de l’angl\u00e8s ‘targeted covalent photoswitches’). S\u00f3n mol\u00e8cules l’estructura de la qual es pot canviar amb llum. Aquest canvi de forma fa que la mol\u00e8cula sigui reconeguda o no per un receptor biol\u00f2gic i que, per tant, s’acobli a ell com ho faria una clau a un pany. <\/p>\n","protected":false},"author":4,"featured_media":25333,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[349,348],"post_formats":[],"class_list":["post-25348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-foto","tag-glutamat"],"yoast_head":"\nMol\u00e8cules que s'activen amb llum per controlar l'activitat dels receptors de glutamat - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/molecules-que-sactiven-amb-llum-per-controlar-lactivitat-dels-receptors-de-glutamat\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mol\u00e8cules que s'activen amb llum per controlar l'activitat dels receptors de glutamat - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC, IQAC-CSIC i CNRS han desenvolupat unes mol\u00e8cules que poden modular l'activitat dels receptors de glutamat en el sistema nervi\u00f3s central, amb importants aplicacions en biomedicina. 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