{"id":27281,"date":"2017-01-31T09:07:19","date_gmt":"2017-01-31T08:07:19","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=27281"},"modified":"2017-01-31T12:07:38","modified_gmt":"2017-01-31T11:07:38","slug":"light-regulated-drugs-as-analgesics","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/light-regulated-drugs-as-analgesics\/","title":{"rendered":"Mol\u00e8cules regulades amb llum per alleujar s\u00edmptomes del dolor cr\u00f2nic"},"content":{"rendered":"

i va acompanyat de s\u00edmptomes com a hipersensibilitat al dolor, ansietat i comportament depressiu. No t\u00e9 cura, el seu tractament \u00e9s dif\u00edcil i els f\u00e0rmacs actuals no aconsegueixen alleujar els s\u00edmptomes.<\/p>\n

En el treball publicat en la revista\u00a0ACS Central Science<\/em>, el grup de Nanosondes\u00a0i Nanocommuntadors\u00a0de l’IBEC juntament amb els seus col\u00b7laboradors, van obtenir una s\u00e8rie de fenilazopiridines, mol\u00e8cules que actuen sobre el receptor mGlu5, un dels dos receptors cerebrals relacionats amb les emocions associades a dolor cr\u00f2nic, com l’ansietat.<\/p>\n

Els assajos, realitzats sobre c\u00e8l\u00b7lules i sobre larves de peixos zebra, demostren que l’administraci\u00f3 localitzada de llum i de les fenilazopiridines fotoconmutables t\u00e9 efectes sobre l’activitat dels receptors mGlu. Aquest efecte dep\u00e8n de la il\u00b7luminaci\u00f3, la qual cosa demostra, expliquen els cient\u00edfics, que es pot regular amb llum l’activitat biol\u00f2gica de les mol\u00e8cules sobre el receptor mGlu5. A m\u00e9s, el treball tamb\u00e9 demostra que l’acci\u00f3 de la llum i mol\u00e8cules fotoconmutables en teixits localitzats, incloent el cervell en ratolins vius, pot regular el seu efecte analg\u00e9sico.<\/p>\n

“Els resultats, encara en etapa preliminar, demostren les possibilitats de desenvolupament futur de ter\u00e0pies basades en la fotofarmacologia”, diu Pau Gorostiza, professor ICREA i responsable de grup a l’IBEC.<\/p>\n

—<\/p>\n

Article referenciat:<\/strong>
\nXavier G\u00f3mez-Santacana, Silvia Pittolo, Xavier Rovira, Marc Lopez, Charleine Zussy, James A. R. Dalton, Ad\u00e8le Faucherre, Chris Jopling, Jean-Philippe Pin, Francisco Ciruela, Cyril Goudet, Jes\u00fas Giraldo, Pau Gorostiza, and Amadeu Llebaria. (2017). Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.<\/a> ACS Central Science<\/em> DOI: 10.1021\/acscentsci.6b00353<\/p>\n

—
\nIBEC en els medis:<\/strong>\u00a0Aquest cap de setmana, Pau Gorostiza va ser\u00a0entrevistat\u00a0en la Radio Nacional de Espa\u00f1a (RNE)<\/a>\u00a0 amb motiu d’aquest estudi. \u00a0Pots\u00a0escoltar-ho\u00a0fent clic sobre l’enlla\u00e7, la seva part comen\u00e7a en el mintu\u00a033\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Un nou estudi, en el qual estan involucrats investigadors de l’IBEC, IQAC\/CSIC i CNRS a Fran\u00e7a, troba noves dianes terap\u00e8utiques per alleujar, mitjan\u00e7ant mol\u00e8cules regulades amb llum, s\u00edmptomes i emocions negatives associats al dolor cr\u00f2nic, com l’ansietat i la por. <\/h3>\n

El dolor cr\u00f2nic \u00e9s aquell que no respon a una causa puntual en el temps i es perllonga m\u00e9s enll\u00e0 de sis mesos o, fins i tot, anys. De vegades \u00e9s dif\u00edcil determinar el seu origen, que pot ser tant fisiol\u00f2gic com a emocional, <\/p>\n","protected":false},"author":4,"featured_media":27337,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-27281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nMol\u00e8cules regulades amb llum per alleujar s\u00edmptomes del dolor cr\u00f2nic - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/light-regulated-drugs-as-analgesics\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mol\u00e8cules regulades amb llum per alleujar s\u00edmptomes del dolor cr\u00f2nic - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un nou estudi, en el qual estan involucrats investigadors de l'IBEC, IQAC\/CSIC i CNRS a Fran\u00e7a, troba noves dianes terap\u00e8utiques per alleujar, mitjan\u00e7ant mol\u00e8cules regulades amb llum, s\u00edmptomes i emocions negatives associats al dolor cr\u00f2nic, com l'ansietat i la por. 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