{"id":27830,"date":"2017-02-28T09:34:04","date_gmt":"2017-02-28T08:34:04","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/ca\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/"},"modified":"2017-03-02T15:18:22","modified_gmt":"2017-03-02T14:18:22","slug":"a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/","title":{"rendered":"Troben una nova diana terap\u00e8utica que podria frenar l’avan\u00e7 del Parkinson"},"content":{"rendered":"
a) Dispositiu microflu\u00eddic emprat en l’estudi. Es poden observar neurones corticals prim\u00e0ries despr\u00e9s de 15 dies de cultiu in vitro. b) Immunolocalitzaci\u00f3 de la versi\u00f3 maligna de l\u2019alfa-sinucle\u00efna (verda) en el dispositiu microflu\u00eddic despr\u00e9s de la inoculaci\u00f3 amb l\u2019alfa-sinucle\u00efna recombinant. c) Fotomicrografia mostrant exemples de neurones corticals adultes amb un contingut significatiu de sinucle\u00efna degenerada 45 dies despr\u00e9s de la injecci\u00f3 de l\u2019alfa-sinucle\u00efna en l’estriat.<\/h6>\n

En el seu estudi, publicat aquesta setmana, els investigadors revelen que, a m\u00e9s de dur a terme aquestes funcions, la PrPc<\/sup> tamb\u00e9 s’uneix a una forma pat\u00f2gena de l\u2019alfa-sinucle\u00efna i fomenta la seva propagaci\u00f3 entre neurones. Aquesta prote\u00efna, quan est\u00e0 fosforil\u00b7lada – o el que \u00e9s el mateix, a la seva forma maligna -, causa la degeneraci\u00f3 i mort neuronal en malalties com el Parkinson. El resultat dels investigadors apunta a la PrPc<\/sup> com una possible diana terap\u00e8utica per frenar l’avan\u00e7 en aquest tipus de patologies.<\/p>\n

Aquesta descoberta cient\u00edfica, fruit de la col\u00b7laboraci\u00f3 entre tres grups de l\u2019IBEC, aix\u00ed com d’investigadors del T\u00f2quio Metropolitan Institute of Medical Science, l’Hospital de Bellvitge i l’Institut de Recerca de la Vall d\u2019Hebron a Barcelona, i l’Institut de Recerca en Enginyeria d’Arag\u00f3 a la Universitat de Saragossa, podria ser rellevant en altres patologies neurodegeneratives, incloent alguns tipus de dem\u00e8ncia, l’Alzheimer o l’atr\u00f2fia multisist\u00e8mica.<\/p>\n

El Parkinson \u00e9s una malaltia neurodegenerativa que afecta al moviment. S’origina quan un tipus particular de neurones es degeneren i moren, afectant a les funcions motores i cognitives del sistema nervi\u00f3s central. Els responsables d’aquesta degeneraci\u00f3 s\u00f3n els cossos de Lewy, uns agregats an\u00f2mals que es formen a l’interior de les neurones a base d’una versi\u00f3 maligna de l\u2019alfa-sinucle\u00efna, una prote\u00efna que abunda al citoplasma de les neurones. Quan l\u2019alfa-sinucle\u00efna no es pot degradar correctament, la seva forma canvia, la prote\u00efna es fosforil\u00b7la i comen\u00e7a a aglomerar-se, creant aquests cossos de Lewy densos i insolubles.<\/p>\n

Aquests agregats proliferen a l’interior de la neurona i desperten la seva resposta autoimmune, que acaba causant el su\u00efcidi de la pr\u00f2pia c\u00e8l\u00b7lula. El proc\u00e9s \u00e9s r\u00e0pid i devastador, at\u00e8s que la forma pat\u00f2gena de l\u2019alfa-sinucle\u00efna \u00e9s capa\u00e7 de propagar-se a trav\u00e9s de les connexions entre neurones, creuant diferents regions del cervell i formant nous cossos de Lewy al seu pas, la qual cosa causa un dany irreversible en un nombre creixent de c\u00e8l\u00b7lules al llarg del temps.<\/p>\n

Els investigadors de l\u2019IBEC i els seus col\u00b7laboradors han observat que la sobre-expressi\u00f3 de la PrPc<\/sup> a la membrana neuronal incrementa la uni\u00f3 i expansi\u00f3 de l\u2019alfa-sinucle\u00efna pat\u00f2gena entre neurones i, m\u00e9s tard, la formaci\u00f3 dels cossos de Lewy. \u201cHem vist clarament com l\u2019alfa-sinucle\u00efna \u00e9s capa\u00e7 de viatjar d’una regi\u00f3 cerebral a unes altres, deixant al seu pas un nombre molt alt de neurones mortes i d\u2019altres moribundes\u201d, diu la Laura Urrea, primera autora de l’estudi.<\/p>\n

\u201cLa PrPc<\/sup> \u00e9s una pe\u00e7a clau per a la propagaci\u00f3 dels cossos de Lewy\u201d, afegeix Jos\u00e9 Antonio Del R\u00edo, coordinado de l’estudi i investigador principal del grup de Neurobiologia Molecular i Cel\u00b7lular de l’IBEC i professor de\u00a0la Universitat de Barcelona (UB). \u201cSi pogu\u00e9ssim evitar que aquestes acumulacions malicioses es formessin i propaguessin, podr\u00edem detenir la progressi\u00f3 de la mort neuronal en malalties com el Parkinson\u201d.<\/p>\n

A m\u00e9s dels seus experiments in vivo<\/em> i in vitro<\/em>, l’equip de Del R\u00edo ha desenvolupat un dispositiu microflu\u00eddic capa\u00e7 de distingir la interacci\u00f3 espec\u00edfica entre la PrPc i l\u2019alfa-sinucle\u00efna que facilita el seu transport entre neurones. \u201cA dia d’avui, hem identificat un domini en la PrPc<\/sup> que podria ser la diana terap\u00e8utica clau per a contenir el transport de l\u2019alfa-sinucle\u00efna entre neurones i aix\u00ed frenar l’avan\u00e7 de la malaltia\u201d, afegeix l’investigador.<\/p>\n

Aquest estudi, en el qual tamb\u00e9 han participat els grups de Nanobioingenieria<\/a>\u00a0i\u00a0Infeccions bacterianes: terapies antimicrobianes<\/a>\u00a0del IBEC -liderats respectivament per Josep Samitier i\u00a0Eduard Torrents, tots dos\u00a0professores de\u00a0la Universitat de Barcelona (UB)-,ha estat possible gr\u00e0cies al finan\u00e7ament de\u00a0La Marat\u00f3 de TV3<\/a>, el MINECO<\/a>\u00a0i el Centre de Recerca Biom\u00e8dica en Xarxa sobre Malalties Neurodegeneratives (CIBERNED<\/a>), entre altres.<\/p>\n

 <\/p>\n

—<\/p>\n

Article:<\/strong> <\/em>Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gav\u00edn R, Hagesawa M, Del R\u00edo JA. (2017). Involvement of Cellular Prion Protein in \u03b1-Synuclein Transport in Neurons.<\/a> Mol Neurobiol.<\/em>, epub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadors de l’IBEC han identificat un possible mecanisme per frenar la progressi\u00f3 neurodegenerativa de la malaltia de Parkinson.\u00a0<\/h3>\n

La clau de l’estudi es troba a la prote\u00efna pri\u00f2nica cel\u00b7lular (PrPc<\/sup>), una mol\u00e8cula especialitzada que es troba a la membrana de les neurones i que participa en moltes de les seves funcions, com el control del cicle cel\u00b7lular i la neurotransmissi\u00f3.<\/p>\n","protected":false},"author":4,"featured_media":27819,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-27830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nTroben una nova diana terap\u00e8utica que podria frenar l'avan\u00e7 del Parkinson - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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