{"id":31113,"date":"2017-07-28T13:28:49","date_gmt":"2017-07-28T11:28:49","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=31113\/"},"modified":"2017-09-05T10:23:33","modified_gmt":"2017-09-05T08:23:33","slug":"un-nou-model-per-lestudi-de-la-migracio-cel%c2%b7lular","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-model-per-lestudi-de-la-migracio-cel%c2%b7lular\/","title":{"rendered":"Un nou model per l’estudi de la migraci\u00f3 cel\u00b7lular"},"content":{"rendered":"
Aquestes imatges mostren col\u00b7lagen (gris) i fibronectina (vermell) en les matrius dissenyades pel grup Nanobioengineering de l’IBEC. La fila superior mostra matrius desordenades (is\u00f2tropes) i la fila inferior alineades (anis\u00f2tropes), amb fletxes blanques indicant l’orientaci\u00f3 de les fibres. El color rosa mostra les imatges fusionades i els \u00faltims panells mostren una an\u00e0lisi de correlaci\u00f3 creuada.<\/h6>\n

A dia d’avui se sap que les propietats f\u00edsiques de la matriu extracel\u00b7lular (MEC), incloent la seva topologia, propietats mec\u00e0niques i composici\u00f3 molecular, s\u00f3n senyals f\u00edsics que es sinergitzen amb comportaments cel\u00b7lulars com la contracci\u00f3 de l’actomiosina – que genera estr\u00e8s mec\u00e0nic en les c\u00e8l\u00b7lules animals – per a regular la migraci\u00f3 cel\u00b7lular.<\/p>\n

No obstant aix\u00f2, \u00e9s un desafiament estudiar aquestes sinergies, perqu\u00e8 mentre que la topologia de la matriu \u00e9s dif\u00edcil de controlar in vivo<\/em>, els models dissenyats in vitro<\/em> manquen de la complexitat bioqu\u00edmica i f\u00edsica de l’entorn cel\u00b7lular.<\/p>\n

Els investigadors necessitaven trobar un model de MEC in vitro capa\u00e7 de reproduir de manera fidel la interacci\u00f3 entre les propietats f\u00edsiques de la matriu amb els factors moleculars que es troben en el cos.<\/p>\n

Treballant en col\u00b7laboraci\u00f3 amb col\u00b7legues del Laboratori Ib\u00e8ric Internacional de Nanotecnologia (INL) en Braga, Portugal, el grup de recerca del director de l’IBEC <\/a> va sembrar c\u00e8l\u00b7lules sobre matrius 3D polaritzades que imitaven les caracter\u00edstiques estructurals i bioqu\u00edmiques de la matriu extracel\u00b7lular in vivo, incloent la seva topologia, que era anis\u00f2tropa (alineada) o is\u00f2tropa (desordenada). Els investigadors van trobar que la direcci\u00f3 del moviment cel\u00b7lular, per\u00f2 no la dist\u00e0ncia recorreguda, persisteix quan les matrius manipulades s\u00f3n topol\u00f2gicament anis\u00f2tropes, per\u00f2 quan no ho s\u00f3n – quan s\u00f3n is\u00f2tropes – la direccionalitat cel\u00b7lular \u00e9s independent de la contractilitat de l’actomiosina.<\/p>\n

Per tant podrien concloure que, per al moviment cel\u00b7lular dirigit, es requereix una sinergia de la contractilitat de l’actomiosina amb l’anisotropia de l’entorn cel\u00b7lular. Tamb\u00e9 van observar que l’anisotropia contraresta la falta de forces dirigides per la actomiosina per millorar la capacitat de les c\u00e8l\u00b7lules per moure’s o envair, i per estabilitzar la seva direccionalitat.<\/p>\n

Aquests avan\u00e7os respecte als mecanismes biof\u00edsics de la migraci\u00f3 cel\u00b7lular dirigida en entorns de tipus natiu poden contribuir a la comprensi\u00f3 de la motilitat direccional de les c\u00e8l\u00b7lules, essencial en processos com el c\u00e0ncer o el desenvolupament embrionari.<\/p>\n

—<\/p>\n

Article referenciat:<\/em> <\/strong>David Caballero, Lucas Palacios, Paulo P. Freitas, Josep Samitier (2017). “An Interplay Between Matrix Anisotropy and Actomyosin Contractility Regulates 3D Directed Cell Migration<\/a>“. Advanced Functional Materials<\/em>, disponible en epub.<\/p>\n

—
\nAquest treball ha estat finan\u00e7at per la beca postdoctoral Beatriu de Pin\u00f3s (COFUND MSCA) de David Caballero a l’IBEC i pel programa “Explora Ciencia” del MINECO.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"El grup Nanobioengineering de l’IBEC ha contrib\u00eft al camp de la mecanobiologia creant un model in vitro <\/em> de matriu extracel\u00b7lular que mostra com interacciona aquest entorn amb l’actomiosina – la proteina que permet a les c\u00e8l\u00b7lules contreure’s per dirigir la seva migraci\u00f3. <\/h3>\n

L’article, publicat en Advanced Functional Materials<\/em> aquesta setmana, aboca llum sobre la migraci\u00f3 cel\u00b7lular, que \u00e9s essencial per a molts processos biol\u00f2gics saludables com el desenvolupament embrionari i la cicatritzaci\u00f3 o la progressi\u00f3 del c\u00e0ncer en la malaltia.<\/p>\n","protected":false},"author":4,"featured_media":30801,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-31113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nUn nou model per l'estudi de la migraci\u00f3 cel\u00b7lular - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-nou-model-per-lestudi-de-la-migracio-cel\u00b7lular\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nou model per l'estudi de la migraci\u00f3 cel\u00b7lular - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup Nanobioengineering de l'IBEC ha contrib\u00eft al camp de la mecanobiologia creant un model in vitro de matriu extracel\u00b7lular que mostra com interacciona aquest entorn amb l'actomiosina - la proteina que permet a les c\u00e8l\u00b7lules contreure's per dirigir la seva migraci\u00f3. 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