{"id":38234,"date":"2017-10-05T17:52:13","date_gmt":"2017-10-05T15:52:13","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=38234"},"modified":"2017-10-11T15:03:36","modified_gmt":"2017-10-11T13:03:36","slug":"una-estrategia-eficac-per-a-la-distribucio-selectiva-de-nous-compostos-antimalarics","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-estrategia-eficac-per-a-la-distribucio-selectiva-de-nous-compostos-antimalarics\/","title":{"rendered":"Una estrat\u00e8gia efica\u00e7 per a la distribuci\u00f3 selectiva de nous compostos antimal\u00e0rics"},"content":{"rendered":"
Els immunoliposomes carregats de f\u00e0rmac afavoreixen l’eliminaci\u00f3 r\u00e0pida del par\u00e0sit i podrien fer-se servir per tractar la mal\u00e0ria greu.<\/h6>\n

Per aix\u00f2, l’equip de Nanomal\u00e0ria<\/a> de l’investigador Fern\u00e1ndez Busquets porta uns anys desenvolupant nanovehicles que alliberin el f\u00e0rmac directa i selectivament en els gl\u00f2buls vermells (eritr\u00f2cits) infectats pel par\u00e0sit. En un estudi previ amb ratolins \u2018humanitzats\u2019, van mostrar que la cloroquina encapsulada en nanoves\u00edcules cobertes amb anticossos (immunoliposomes) contra una prote\u00efna d’eritr\u00f2cits era m\u00e9s efica\u00e7 en eliminar el par\u00e0sit que la cloroquina lliure. No obstant aix\u00f2, l’OMS ha deixat de recomanar la cloroquina a causa de la pres\u00e8ncia global de par\u00e0sits resistents a la mateixa.<\/p>\n

En aquest estudi, els investigadors van aplicar una t\u00e8cnica similar amb nous antimal\u00e0rics que escapen als mecanismes de resist\u00e8ncia: una amiquinolina i un aminoalcohol. Primer, van validar un m\u00e8tode per carregar eficientment els liposomes amb aquests f\u00e0rmacs, i un antic\u00f2s que permet dirigir-los de manera espec\u00edfica als eritr\u00f2cits. Despr\u00e9s, van demostrar que aquests immunoliposomes, quan es subministren a ratolins infectats amb Plasmodium yoelli<\/em> (que causa una malaltia similar a la dels humans), disminueixen de manera considerable la densitat de par\u00e0sits en la sang- prou per passar de mal\u00e0ria greu a mal\u00e0ria sense complicacions- a difer\u00e8ncia del f\u00e0rmac encapsulat en ves\u00edcules no cobertes per anticossos.<\/p>\n

\u201cHi ha una necessitat urgent d’augmentar el repertori de f\u00e0rmacs per tractar la mal\u00e0ria greu. Els immunoliposomas que descrivim en aquest estudi representen una eina atractiva ja que actuen de manera r\u00e0pida i dirigida per eliminar el par\u00e0sit d’eritr\u00f2cits infectats\u201d explica Fern\u00e1ndez Busquets, investigador d\u2019ISGlobal, centre impulsat per la Fundaci\u00f3 Banc\u00e0ria \u201cla Caixa\u201d. <\/p>\n

Els autors conclouen que es necessita millorar el temps mitj\u00e0 de vida dels immunoliposomas en la sang i reduir el seu efecte d’aglutinaci\u00f3 d’eritr\u00f2cits perqu\u00e8 el prototip descrit en l’estudi pugui ser usat en la cl\u00ednica.<\/p>\n

—<\/p>\n

Article referenciat:<\/strong><\/em> Moles\u00a0E, Galiano S, Gomes A, Quiliano M, Teixeira C, Aldana I, Gomes P, Fern\u00e0ndez-Busquets X. (2017). ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model.<\/a> Biomaterials<\/em>, 145:178-191.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\" L’equip de Xavier Fern\u00e1ndez Busquets, director de la unitat mixta de nanomal\u00e0ria ISGlobal-IBEC, fa una passa m\u00e9s en la validaci\u00f3 dels immunoliposomes com a vehicle de f\u00e0rmacs antimal\u00e0rics al mostrar que augmenten l’efic\u00e0cia de nous compostos lipof\u00edlics (poc solubles en aigua) en un model de mal\u00e0ria en ratol\u00ed.<\/h3>\n

Els resultats, publicats en Biomaterials<\/em>, suggereixen que aquesta estrat\u00e8gia podria usar-se per al tractament de la mal\u00e0ria greu.
\nMolts dels f\u00e0rmacs antimal\u00e0rics que s’estan desenvolupant actualment s\u00f3n poc solubles en aigua, per la qual cosa necessiten subministrar-se en altes dosis per assegurar la seva efic\u00e0cia.<\/p>\n","protected":false},"author":4,"featured_media":38107,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-38234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nUna estrat\u00e8gia efica\u00e7 per a la distribuci\u00f3 selectiva de nous compostos antimal\u00e0rics - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-estrategia-eficac-per-a-la-distribucio-selectiva-de-nous-compostos-antimalarics\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una estrat\u00e8gia efica\u00e7 per a la distribuci\u00f3 selectiva de nous compostos antimal\u00e0rics - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L'equip de Xavier Fern\u00e1ndez Busquets, director de la unitat mixta de nanomal\u00e0ria ISGlobal-IBEC, fa una passa m\u00e9s en la validaci\u00f3 dels immunoliposomes com a vehicle de f\u00e0rmacs antimal\u00e0rics al mostrar que augmenten l'efic\u00e0cia de nous compostos lipof\u00edlics (poc solubles en aigua) en un model de mal\u00e0ria en ratol\u00ed. 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