{"id":38329,"date":"2017-10-13T11:30:17","date_gmt":"2017-10-13T09:30:17","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=38329"},"modified":"2017-10-24T10:22:07","modified_gmt":"2017-10-24T08:22:07","slug":"micronedadors-usen-bacteris-sans-para-atacar-les-biopel%c2%b7licules-nocives","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/micronedadors-usen-bacteris-sans-para-atacar-les-biopel%c2%b7licules-nocives\/","title":{"rendered":"Micronedadors usen bacteris &#8216;sans&#8217; para atacar les biopel\u00b7l\u00edcules nocives"},"content":{"rendered":"<h6 class=\"caption\" style=\"float: left; width: 100%; padding: 0px 40px 10px 0px;\">A dalt a l&#8217;esquerra: c\u00e8l\u00b7lules MSR-1 capturades dins d&#8217;un microtub; a dalt a la dreta: bioh\u00edbrid atrapat en una biopel\u00b7l\u00edcula d&#8217;E. coli.<\/h6>\n<p>Les col\u00f2nies que proliferen en les biopel\u00b7l\u00edcules generalment s\u00f3n resistents als antibi\u00f2tics i requereixen de m\u00e8todes espec\u00edfics d&#8217;eliminaci\u00f3. Un d&#8217;aquests m\u00e8todes utilitza nanopart\u00edcules com a portadors per a l&#8217;administraci\u00f3 d&#8217;antibi\u00f2tics, que circulen de forma aleat\u00f2ria en l\u00edquid fins que entren en contacte amb les \u00e0rees infectades. No obstant aix\u00f2, aquests no s\u00f3n molt efectius, ja que necessiten poder acostar-se molt a la biopel\u00b7l\u00edcula.<\/p>\n<p>En l&#8217;article publicat en <em>ACS Nano<\/em>, el grup i els seus col\u00b7laboradors del <em>Max Planck Institute for Intelligent Systems<\/em> de Stuttgart demostren que els bacteris no pat\u00f2gens <em>Magnetosopirrillum gryphiswalense<\/em> (MSR-1) poden integrar-se amb els microtubs carregats de f\u00e0rmac per construir sistemes bioh\u00edbrids controlables o &#8216;micronedadors&#8217; capa\u00e7os d&#8217;administrar antibi\u00f2tics per combatre una biopel\u00b7l\u00edcula infecciosa.<\/p>\n<p>&#8220;Aplicant la capacitat d&#8217;orientaci\u00f3 magn\u00e8tica externa i el potencial de les c\u00e8l\u00b7lules MSR-1 com a nedadors, els nostres bioh\u00edbrids poden ser dirigits i introdu\u00efts en biopel\u00edcul\u00b7les madures d&#8217;E. <em>coli<\/em>&#8220;, explica el Professor ICREA i investigador principal de l&#8217;IBEC, Samuel S\u00e1nchez. &#8220;L&#8217;alliberament de l&#8217;antibi\u00f2tic, ciprofloxacina, \u00e9s desencadenada pel microambient \u00e0cid de la biopel\u00b7l\u00edcula&#8221;.<\/p>\n<p>En revisar les biopel\u00b7l\u00edcules que van tractar amb els seus bioh\u00edbrids despr\u00e9s de 24 hores i de 48 hores respectivament, els investigadors van veure que les biopel\u00b7l\u00edcules no tornaven a formar-se. &#8220;Els nostres bioh\u00edbrids penetren profundament en les capes i impedeixen la progressi\u00f3 de la biopel\u00b7l\u00edcula&#8221;, afirma Samuel.<\/p>\n<p>La capacitat dels bacteris no pat\u00f2gens per dirigir-se i desmantellar biopel\u00b7l\u00edcules nocives obre les portes al seu \u00fas per a sistemes bioh\u00edbrids en aplicacions anti-biopel\u00b7l\u00edcula en el futur.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Article referenciat:<\/strong> <\/em>Morgan M. Stanton, Byung-Wook Park, Diana Vilela, Klaas Bente, Damien Faivre, Metin Sitti, and Samuel S\u00e1nchez (2017). <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.7b04128\" target=\"_blank\" rel=\"noopener\">Magnetotactic Bacteria Powered Biohybrids Target E. coli Biofilms.<\/a> <em>ACS Nano<\/em>, 10.1021\/acsnano.7b04128<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/10\/Samuel_ACS_Nano_biofilms.jpg\" alt=\"\" width=\"500\" height=\"325\" class=\"left size-full wp-image-38242 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/325;\" \/> L&#8217;\u00faltim article del grup <em>Smart nano-bio-devices<\/em> de l&#8217;IBEC aborda el problema de les biopel\u00b7l\u00edcules, les &#8220;ciutats de microbis&#8221; que faciliten la comunicaci\u00f3 de c\u00e8l\u00b7lula a c\u00e8l\u00b7lula entre els bacteris, permetent que la infecci\u00f3 prosperi i augmentant les possibilitats d&#8217;evadir el sistema immune. En el cos, aquestes biopel\u00b7l\u00edcules es poden trobar en una \u00e0mplia varietat d&#8217;infeccions microbianes, com en els pulmons dels pacients amb fibrosis qu\u00edstica o en la malaltia pulmonar obstructiva cr\u00f2nica (EPOC). <\/h3>\n","protected":false},"author":4,"featured_media":38242,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-38329","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Micronedadors usen bacteris &#039;sans&#039; para atacar les biopel\u00b7l\u00edcules nocives - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/micronedadors-usen-bacteris-sans-para-atacar-les-biopel\u00b7licules-nocives\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Micronedadors usen bacteris &#039;sans&#039; para atacar les biopel\u00b7l\u00edcules nocives - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L&#039;\u00faltim article del grup Smart nano-bio-devices de l&#039;IBEC aborda el problema de les biopel\u00b7l\u00edcules, les &quot;ciutats de microbis&quot; que faciliten la comunicaci\u00f3 de c\u00e8l\u00b7lula a c\u00e8l\u00b7lula entre els bacteris, permetent que la infecci\u00f3 prosperi i augmentant les possibilitats d&#039;evadir el sistema immune. En el cos, aquestes biopel\u00b7l\u00edcules es poden trobar en una \u00e0mplia varietat d&#039;infeccions microbianes, com en els pulmons dels pacients amb fibrosis qu\u00edstica o en la malaltia pulmonar obstructiva cr\u00f2nica (EPOC).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/micronedadors-usen-bacteris-sans-para-atacar-les-biopel\u00b7licules-nocives\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-10-13T09:30:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-10-24T08:22:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/10\/Samuel_ACS_Nano_biofilms.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"172\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/micronedadors-usen-bacteris-sans-para-atacar-les-biopel%c2%b7licules-nocives\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/micronedadors-usen-bacteris-sans-para-atacar-les-biopel%c2%b7licules-nocives\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Micronedadors usen bacteris &#8216;sans&#8217; 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