Nanoscale Organization of the Pathogen Receptor DC-SIGN Mapped by Single-Molecule High-Resolution Fluorescence Microscopy<\/p>\n
Les malalties infeccioses tenen efectes devastadors en una gran part de la poblaci\u00f3 mundial i en el seu desenvolupament socio-econ\u00f2mic. El sistema immunitari \u00e9s la nostra defensa enfront dels microorganismes pat\u00f2gens. Les c\u00e8l\u00b7lules dendr\u00edtiques (DC) tenen un paper fonamental en la resposta immunit\u00e0ria al capturar pat\u00f2gens en els teixits perif\u00e8rics i migrar-los als n\u00f2duls limf\u00e0tics, transferint per tant informaci\u00f3 a les c\u00e8l\u00b7lules T i B. Les c\u00e8l\u00b7lules dendr\u00edtiques, unes de les primeres c\u00e8l\u00b7lules del sistema immunitari que entren en contacte amb pat\u00f2gens, estan equipades amb una mir\u00edada de receptors de reconeixement i captura de pat\u00f2gens. Un d’aquests receptors \u00e9s el DC-SIGN, una lectina de tipus C.<\/p>\n
Encara que ja es disposava de molta informaci\u00f3 rellevant sobre l’estructura del DC-SIGN, encara no hi havia dades concretes sobre si aquest receptor era capa\u00e7 de recon\u00e8ixer de manera efica\u00e7 una \u00e0mplia gamma de pat\u00f2gens, incl\u00f2s el virus VIH. Usant una t\u00e8cnica de microscopia \u00f2ptica d’alta resoluci\u00f3 (NSOM), al laboratori de Bionanofot\u00f2nica, van observar que el DC-SIGN est\u00e0 organitzat en diferents dominis de grand\u00e0ria nanom\u00e8trica. El fet que aix\u00f2 no s’hagi conegut anteriorment est\u00e0 relacionat amb la limitada resoluci\u00f3 dels microscopis \u00f2ptics (el l\u00edmit de difracci\u00f3 de llum visible \u00e9s de 350-500 nm, depenent de la longitud d’ona) i amb el fet que no era f\u00e0cil estudiar grans superf\u00edcies de c\u00e8l\u00b7lules a alta resoluci\u00f3. Un nou m\u00f3n es fa visible!<\/p>\n
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