{"id":5218,"date":"2010-01-13T16:11:54","date_gmt":"2010-01-13T16:11:54","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/simulacio-computacional-per-predir-el-comportament-de-bastida-per-a-teixit-ossi-implantada-in-vivo\/"},"modified":"2015-01-15T15:53:43","modified_gmt":"2015-01-15T15:53:43","slug":"simulacio-computacional-per-predir-el-comportament-de-bastida-per-a-teixit-ossi-implantada-in-vivo","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/simulacio-computacional-per-predir-el-comportament-de-bastida-per-a-teixit-ossi-implantada-in-vivo\/","title":{"rendered":"Simulaci\u00f3 computacional per predir el comportament de bastida per a teixit ossi implantada in vivo"},"content":{"rendered":"<p>En l\u2019estudi\u00a0<a title=\"doi.org\/10.1016\/j.biomaterials.2009.11.063\" href=\"http:\/\/dx.doi.org\/10.1016\/j.biomaterials.2009.11.063\" target=\"_blank\">Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach<\/a> publicat a Biomaterials, Clara Sandino i Damien Lacroix de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i investigadors del Trinity College de Dublin, Irlanda, han simulat l\u2019angiog\u00e8nesi i la diferenciaci\u00f3 de teixits en una bastida per aplicar-la en enginyeria de teixit ossi. En una bastida de porositat heterog\u00e8nia, el creixement dels vasos i la diferenciaci\u00f3 de les c\u00e8l\u00b7lules dintre dels porus de la bastida es van determinar d\u2019acord a est\u00edmuls mec\u00e0nics locals i les propietats mec\u00e0niques es van actualitzar basant-se en un concepte de mecanoregulaci\u00f3. Al comen\u00e7ament de la simulaci\u00f3, es va trobar que els vasos creixien en els porus exteriors de la bastida, per\u00f2 que estaven bloquejats per les parets d\u2019aquesta i no podien arribar al centre de la mostra.<\/p>\n<p>Al final de la simulaci\u00f3, es van predir diferents tipus de c\u00e8l\u00b7lules en tota la bastida d\u2019acord amb els est\u00edmuls i l\u2019aportaci\u00f3 d\u2019oxigen. Els osteoblasts es van predir en porus a la perif\u00e8ria de la mostra, prop dels vasos, els condr\u00f2cits als porus del centre de la bastida i els fibroblasts en les estretes regions de l\u2019estructura porosa on els est\u00edmuls eren m\u00e9s alts.<\/p>\n<p>Comparant aquesta construcci\u00f3 heterog\u00e8nia amb\u00a0 bastides de morfologia regular, que es poden obtenir fent servir el rapid prototyping per exemple, \u00e9s possible entendre de quina manera la interconnectivitat dels porus influeix en la formaci\u00f3 tissular dintre de les bastides. La morfologia irregular pot ser la causa tant del bloqueig del creixement de vasos com dels pics d\u2019est\u00edmuls mec\u00e0nics, que t\u00e9 un important efecte en el comportament de la bastida. Aquests resultats s\u00f3n rellevants per entendre el comportament de les bastides quan s\u2019implanten in vivo. Un dels resultats clau \u00e9s la sensibilitat de la diferenciaci\u00f3 tissular a la c\u00e0rrega mec\u00e0nica. Els resultats d\u2019aquest estudi poden, per tant, explicar part de la variabilitat trobada en els bioreactors in vitro i en els estudis in vivo.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-5214\" src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2010\/01\/simulation bone scaffold.jpg\" alt=\"\" width=\"400\" height=\"300\" border=\"0\" srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2010\/01\/simulation%20bone%20scaffold.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2010\/01\/simulation%20bone%20scaffold-300x225.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2010\/01\/simulation%20bone%20scaffold-200x150.jpg 200w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2010\/01\/simulation%20bone%20scaffold-150x112.jpg 150w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>L\u2019aportaci\u00f3 d\u2019oxigen i nutrients des dels capil\u00b7lars, aix\u00ed com els est\u00edmuls mec\u00e0nics transmesos a les c\u00e8l\u00b7lules s\u00f3n factors crucials que influeixen en la diferenciaci\u00f3 de teixits. L\u2019efecte d\u2019aquests dos factors es pot investigar fent servir models computacionals mecanobiol\u00f2gics.<\/h3>\n","protected":false},"author":4,"featured_media":5216,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-5218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Simulaci\u00f3 computacional per predir el comportament de bastida per a teixit ossi implantada in vivo - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/simulacio-computacional-per-predir-el-comportament-de-bastida-per-a-teixit-ossi-implantada-in-vivo\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simulaci\u00f3 computacional per predir el comportament de bastida per a teixit ossi implantada in vivo - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L\u2019aportaci\u00f3 d\u2019oxigen i nutrients des dels capil\u00b7lars, aix\u00ed com els est\u00edmuls mec\u00e0nics transmesos a les c\u00e8l\u00b7lules s\u00f3n factors crucials que influeixen en la diferenciaci\u00f3 de teixits. 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