{"id":5325,"date":"2010-09-10T09:17:36","date_gmt":"2010-09-10T09:17:36","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/pnas-publica-un-article-dinvestigadors-de-libec\/"},"modified":"2015-01-15T15:49:40","modified_gmt":"2015-01-15T15:49:40","slug":"pnas-publica-un-article-dinvestigadors-de-libec","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/pnas-publica-un-article-dinvestigadors-de-libec\/","title":{"rendered":"PNAS publica un article d\u2019investigadors de l\u2019IBEC"},"content":{"rendered":"<p>Fent servir microscopia \u00f2ptica de camp proper amb detecci\u00f3 de mol\u00e8cules individuals (NSOM) el grup \u2013 junt amb col\u00b7laboradors del Centre M\u00e8dic de la Universitat Radboud de Nijmegen, als Pa\u00efsos Baixos \u2013 varen alterar el nanopaisatge d\u2019aquests rais lip\u00eddics i varen visualitzar la formaci\u00f3 de nanodominis de l\u00edpids GM1 amb mides menors de 120 nm i que depenen del colesterol. Posteriors experiments in silico amb col\u00b7laboradors de la Universitat de Barcelona i del grup Co.S.Mo del PCB varen complementar les dades d\u2019alta resoluci\u00f3 per a demostrar de forma concloent l\u2019exist\u00e8ncia de interconnectivitat a l\u2019escala nanom\u00e8trica en la membrana cel\u00b7lular i basada en els rais lip\u00eddics.<\/p>\n<p>Aquestes troballes constitueixen un pas clau envers una millor comprensi\u00f3 en els processos relacionats amb l\u2019activaci\u00f3 i agrupaci\u00f3 dels components dels rais lip\u00eddics, que amplifiquen i reforcen les interaccions preexistents i intervenen en la transducci\u00f3 de senyals a trav\u00e9s de la membrana cel\u00b7lular.<\/p>\n<p>La <span style=\"font-style: italic;\">Proc. Natl. Acad. Sci. USA<\/span> (<span style=\"font-style: italic;\">PNAS<\/span>) est\u00e0 considerada una de les revistes de major impacte en tots els camps, i ocupa el segon lloc en la llista de les Deu Revistes M\u00e9s Citades 1999-2009 de ScienceWatch.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3>El grup de Maria Garcia-Parajo, Bionanofot\u00f2nica de Mol\u00e8cules Individuals, obt\u00e9 el primer article important despr\u00e9s de la pausa de l\u2019estiu, amb la publicaci\u00f3 \u201cDirect mapping of nanoscale compositional connectivity on intact cell membranes\u201d, el 31 d\u2019agost a la revista. <\/h3>\n<p>En la seva recerca sobre la membrana cel\u00b7lular, on components preorganitzats d\u00f3nen lloc a avantatges estrat\u00e8giques per a la funci\u00f3 i senyalitzaci\u00f3 cel\u00b7lular, Maria i el seu equip han estat investigant els rais lip\u00eddics \u2013 regions de la membrana que concentren prote\u00efnes i l\u00edpids i suren lliurement \u2013 i han demostrat la seva connectivitat selectiva a una escala nanom\u00e8trica a trav\u00e9s del colesterol.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-5325","post","type-post","status-publish","format-standard","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PNAS publica un article d\u2019investigadors de l\u2019IBEC - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/pnas-publica-un-article-dinvestigadors-de-libec\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PNAS publica un article d\u2019investigadors de l\u2019IBEC - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup de Maria Garcia-Parajo, Bionanofot\u00f2nica de Mol\u00e8cules Individuals, obt\u00e9 el primer article important despr\u00e9s de la pausa de l\u2019estiu, amb la publicaci\u00f3 \u201cDirect mapping of nanoscale compositional connectivity on intact cell membranes\u201d, el 31 d\u2019agost a la revista.  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