{"id":5396,"date":"2010-11-12T14:05:29","date_gmt":"2010-11-12T14:05:29","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/vencer-els-bloquejants-de-la-regeneracio\/"},"modified":"2015-01-15T15:31:30","modified_gmt":"2015-01-15T15:31:30","slug":"vencer-els-bloquejants-de-la-regeneracio","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/","title":{"rendered":"V\u00e8ncer els bloquejants de la regeneraci\u00f3"},"content":{"rendered":"

Ara, investigadors de l\u2019IBEC han descobert un nou grup de lligands per a receptors relacionats amb la mielina, que podrien aclarir la transcend\u00e8ncia de la producci\u00f3 desequilibrada d\u2019aquesta subst\u00e0ncia o les seves modificacions.<\/p>\n

En un estudi publicat online per la revista FASEB aquesta setmana, el director del grup Jos\u00e9 Antonio del R\u00edo, junt amb els seus postdocs Vanessa Gil i Franc Llorens, han estat estudiant els axons, lligands i receptors del sistema nervi\u00f3s central dels mam\u00edfers. En adults, la capacitat per a tornar a cr\u00e9ixer dels axons despr\u00e9s d\u2019una lesi\u00f3 \u00e9s limitada aquesta restricci\u00f3 la causen els inhibidors associats a la mielina (MAIs).<\/p>\n

En evitar la inhibici\u00f3 de la mielina la regeneraci\u00f3 neuronal millora, i els tres investigadors del grup de Neurobiotecnologia Molecular i Cel\u00b7lular han descobert que en bloquejar dos d\u2019alguns dels receptors compartits per aquestes prote\u00efnes \u2013NgR1, junt amb els seus coreceptors p75(NTR), TROY i Lingo-1, i el corresponent receptor B semblant a la immunoglobulina (PirB) \u2013 impedeix als inhibidors restringir els brots axonals i limitar la regeneraci\u00f3 de trams de fibres danyades.<\/p>\n

Altres elements de la ruta inhibidora de la mielina segueixen essent desconeguts, per\u00f2 aquesta identificaci\u00f3 i caracteritzaci\u00f3 dels rols i funcions d\u2019algunes de les mol\u00e8cules inhibidores \u00e9s un avan\u00e7 dins d\u2019una de les \u00e0rees de recerca en neuroregeneraci\u00f3 m\u00e9s competitiva dels darrers anys. A m\u00e9s a m\u00e9s, altres dades tant del CNS com externes suggereixen que la majoria d\u2019aquestes prote\u00efnes tenen altres funcions a part de la inhibici\u00f3 del creixement axonal. \u201cPot ser que tinguin altres funcions fisiol\u00f2giques en altres processos com el desenvolupament, la homeostasi neuronal, la plasticitat i la neurodegeneraci\u00f3\u201d, diu Jos\u00e9 Antonio. \u201cLes modificacions es podrien considerar marcadors de certes malalties neuronals\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors identifiquen mol\u00e8cules inhibidores de la neuroregeneraci\u00f3<\/h3>\n

Es sap que el desenvolupament de malalties neuronals com l\u2019esclerosi m\u00faltiple i la malaltia d\u2019Alzheimer est\u00e0 relacionat amb els nivells de mielina \u2013una subst\u00e0ncia a\u00efllant que envolta les fibres nervioses- del cos, tot i que les veritables causes d\u2019aquestes afeccions segueixen sent desconegudes. <\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-5396","post","type-post","status-publish","format-standard","hentry","category-noticies-de-recerca"],"yoast_head":"\nV\u00e8ncer els bloquejants de la regeneraci\u00f3 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"V\u00e8ncer els bloquejants de la regeneraci\u00f3 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors identifiquen mol\u00e8cules inhibidores de la neuroregeneraci\u00f3 Es sap que el desenvolupament de malalties neuronals com l\u2019esclerosi m\u00faltiple i la malaltia d\u2019Alzheimer est\u00e0 relacionat amb els nivells de mielina \u2013una subst\u00e0ncia a\u00efllant que envolta les fibres nervioses- del cos, tot i que les veritables causes d\u2019aquestes afeccions segueixen sent desconegudes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2010-11-12T14:05:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-01-15T15:31:30+00:00\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"V\u00e8ncer els bloquejants de la regeneraci\u00f3\",\"datePublished\":\"2010-11-12T14:05:29+00:00\",\"dateModified\":\"2015-01-15T15:31:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/\"},\"wordCount\":309,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/\",\"name\":\"V\u00e8ncer els bloquejants de la regeneraci\u00f3 - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"datePublished\":\"2010-11-12T14:05:29+00:00\",\"dateModified\":\"2015-01-15T15:31:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/vencer-els-bloquejants-de-la-regeneracio\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"V\u00e8ncer els bloquejants de la regeneraci\u00f3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\",\"name\":\"\u00c0ngels L\u00f3pez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"caption\":\"\u00c0ngels L\u00f3pez\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/alopez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"V\u00e8ncer els bloquejants de la regeneraci\u00f3 - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/","og_locale":"ca_ES","og_type":"article","og_title":"V\u00e8ncer els bloquejants de la regeneraci\u00f3 - Institute for Bioengineering of Catalonia","og_description":"Investigadors identifiquen mol\u00e8cules inhibidores de la neuroregeneraci\u00f3 Es sap que el desenvolupament de malalties neuronals com l\u2019esclerosi m\u00faltiple i la malaltia d\u2019Alzheimer est\u00e0 relacionat amb els nivells de mielina \u2013una subst\u00e0ncia a\u00efllant que envolta les fibres nervioses- del cos, tot i que les veritables causes d\u2019aquestes afeccions segueixen sent desconegudes.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2010-11-12T14:05:29+00:00","article_modified_time":"2015-01-15T15:31:30+00:00","author":"\u00c0ngels L\u00f3pez","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"\u00c0ngels L\u00f3pez","Temps estimat de lectura":"2 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/"},"author":{"name":"\u00c0ngels L\u00f3pez","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8"},"headline":"V\u00e8ncer els bloquejants de la regeneraci\u00f3","datePublished":"2010-11-12T14:05:29+00:00","dateModified":"2015-01-15T15:31:30+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/"},"wordCount":309,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/","url":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/","name":"V\u00e8ncer els bloquejants de la regeneraci\u00f3 - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"datePublished":"2010-11-12T14:05:29+00:00","dateModified":"2015-01-15T15:31:30+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/vencer-els-bloquejants-de-la-regeneracio\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"V\u00e8ncer els bloquejants de la regeneraci\u00f3"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8","name":"\u00c0ngels L\u00f3pez","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","caption":"\u00c0ngels L\u00f3pez"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/alopez\/"}]}},"AFP_featured_media_urls":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false},"AFP_attachments":[],"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/5396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=5396"}],"version-history":[{"count":0,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/5396\/revisions"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=5396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=5396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=5396"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=5396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}