{"id":55831,"date":"2017-10-27T09:48:01","date_gmt":"2017-10-27T07:48:01","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=55831"},"modified":"2017-10-27T11:21:25","modified_gmt":"2017-10-27T09:21:25","slug":"investigadors-de-libec-desvetllen-com-les-forces-fisiques-activen-gens-implicats-en-el-cancer","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-desvetllen-com-les-forces-fisiques-activen-gens-implicats-en-el-cancer\/","title":{"rendered":"Investigadors de l\u2019IBEC desvetllen com les forces f\u00edsiques activen gens implicats en el c\u00e0ncer"},"content":{"rendered":"

La prote\u00efna YAP, a m\u00e9s de governar, per exemple, el creixement dels \u00f2rgans durant el desenvolupament embrionari, \u00e9s un conegut oncog\u00e8n que activa la transcripci\u00f3 de gens que promouen el c\u00e0ncer en augmentar la proliferaci\u00f3 i impedir la mort de les c\u00e8l\u00b7lules canceroses. Els investigadors de l\u2019IBEC van observar que quan les forces no arribaven al nucli de la c\u00e8l\u00b7lula, YAP romania en equilibri entre el citoplasma i el nucli.<\/p>\n

D’altra banda, quan les forces afectaven al nucli, com passa en \u00e0rees de teixit tumoral que s\u00f3n particularment r\u00edgides, les c\u00e8l\u00b7lules responien obrint els porus del nucli i permetent que entr\u00e9s m\u00e9s YAP. Aix\u00f2 activa als gens implicats en la proliferaci\u00f3 o superviv\u00e8ncia cel\u00b7lular, i permet que el c\u00e0ncer es dissemini i creixi.<\/p>\n

 <\/p>\n

\"\"
\n“Ara comprenem com la rigidesa del teixit tumoral afecta les c\u00e8l\u00b7lules a gen\u00e8ticament, promovent l’estrat\u00e8gia de superviv\u00e8ncia de les c\u00e8l\u00b7lules canceroses”, diu el Pere Roca-Cusachs, investigador principal del grup Mecanobiologia molecular i cel\u00b7lular de l\u2019IBEC i professor agregat de la Universitat de Barcelona (UB), que va dur a terme l’estudi juntament amb el grup Biomec\u00e0nica cel\u00b7lular i respirat\u00f2ria de l\u2019IBEC, i en col\u00b7laboraci\u00f3 amb investigadors del King’s College a Londres.<\/p>\n

En el panell superior, la c\u00e8l\u00b7lula no reacciona a les forces, i YAP roman en equilibri entre el citoplasma i el nucli. En el panell inferior, la c\u00e8l\u00b7lula reacciona a les forces f\u00edsiques i aix\u00f2 promou l’entrada de YAP al nucli a trav\u00e9s dels porus cel\u00b7lulars.<\/h6>\n

“Utilitzant com a diana terap\u00e8utica la connexi\u00f3 mec\u00e0nica entre el nucli i el cos de la c\u00e8l\u00b7lula, el seu esquelet, podr\u00edem prevenir els efectes adversos de la rigidesa tissular en el c\u00e0ncer o la fibrosi”, afegeix l’Alberto Elosegui-Artola, investigador s\u00e8nior a l\u2019IBEC i primer autor de l’estudi. Aquest mecanisme de mecanodetecci\u00f3 tamb\u00e9 podria ser utilitzat per les c\u00e8l\u00b7lules en altres processos on les forces juguen un paper important, com en el desenvolupament embrionari.<\/p>\n

Aquest treball ha estat finan\u00e7at per la Comissi\u00f3 Europea, el Ministeri d’Economia i Competitivitat d’Espa\u00f1a, el Consell Europeu de Recerca, l’Obra Social “La Caixa”, la Fundaci\u00f3 la Marat\u00f3 de Tv3 i el Govern Basc.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia: <\/strong>A. Elosegui-Artola, I. Andreu, A. E.M. Beedle, A. Lezamiz, M. Uroz, A. J. Kosmalska, R. Oria, J. Z. Kechagia, P. Rico-Lastres, A.-L. Le Roux, C. M. Shanahan, X. Trepat, D. Navajas, S. Garcia-Manyes and P. Roca-Cusachs (2017). Force triggers YAP nuclear entry by regulating transport across nuclear pores.<\/a> Cell<\/em>, in press<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"En un estudi publicat avui en la revista Cell, investigadors de l’IBEC, liderats per Pere Roca-Cusachs, revelen com les forces desencadenen l’expressi\u00f3 de gens promotors del c\u00e0ncer mitjan\u00e7ant l’activaci\u00f3 de la prote\u00efna YAP en el nucli cel\u00b7lular.<\/h3>\n

Les c\u00e8l\u00b7lules apliquen forces mec\u00e0niques al teixit que les envolta, produint un efecte crucial per a la funci\u00f3 del teixit sa. En malalties com el c\u00e0ncer o la fibrosi hep\u00e0tica i pulmonar, el teixit es torna m\u00e9s r\u00edgid i les forces mec\u00e0niques augmenten, promovent la progressi\u00f3 de la malaltia.<\/p>\n","protected":false},"author":4,"featured_media":55804,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-55831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nInvestigadors de l\u2019IBEC desvetllen com les forces f\u00edsiques activen gens implicats en el c\u00e0ncer - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-desvetllen-com-les-forces-fisiques-activen-gens-implicats-en-el-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l\u2019IBEC desvetllen com les forces f\u00edsiques activen gens implicats en el c\u00e0ncer - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En un estudi publicat avui en la revista Cell, investigadors de l'IBEC, liderats per Pere Roca-Cusachs, revelen com les forces desencadenen l'expressi\u00f3 de gens promotors del c\u00e0ncer mitjan\u00e7ant l'activaci\u00f3 de la prote\u00efna YAP en el nucli cel\u00b7lular. 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