{"id":56684,"date":"2017-11-30T17:04:47","date_gmt":"2017-11-30T16:04:47","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=56684"},"modified":"2017-12-01T11:41:49","modified_gmt":"2017-12-01T10:41:49","slug":"investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\/","title":{"rendered":"Investigadors de l&#8217;IBEC dissenyen un contacte el\u00e8ctric amb una sola prote\u00efna"},"content":{"rendered":"<h6 class=\"caption\" style=\"float: left; padding: 0px 30px 10px 0px;\">Transfer\u00e8ncia d&#8217;electrons en la proteina azurina sense la mutaci\u00f3 (esquerra, transport en dos passos) i despr\u00e9s de la mutaci\u00f3 puntual (dreta, transport per efecte t\u00fanel).<\/h6>\n<p> &nbsp;<\/p>\n<p>La bioelectr\u00f2nica avan\u00e7a cap al disseny de plataformes electr\u00f2niques en la nanoescala, que permetin connectar biomol\u00e8cules complexes a dispositius electr\u00f2nics per la transducci\u00f3n de senyals. L&#8217;apropament a aquestes tecnologies ha de ser de \u201cbaix-a-dalt\u201d: necessitem entendre la signatura el\u00e8ctrica de les biomol\u00e8cules m\u00e9s simples per crear despr\u00e9s circuits m\u00e9s complexos o entendre estructures macromoleculars.<\/p>\n<p>Amb aquest objectiu, el <a href=\"https:\/\/ibecbarcelona.eu\/nanoprobes\" target=\"_blank\" rel=\"noopener\">grup de l&#8217;investigador principal de l&#8217;IBEC i professor de recerca ICREA Pau Gorostiza<\/a> ha desenvolupat un contacte el\u00e8ctric d&#8217;una sola prote\u00efna capa\u00e7 de transportar c\u00e0rrega el\u00e8ctrica de forma eficient. Els resultats revelen que una sola mutaci\u00f3 puntual en l&#8217;Azurina, la biomol\u00e8cula emprada en l&#8217;estudi, promou un eficient efecte t\u00fanel als electrons que la travessen. \u201cLa Azurina t\u00e9 un \u00e0tom de coure; normalment, el transport electr\u00f2nic intervingut per aquest metall succeeix en dos passos per a cada electr\u00f3; amb una sola mutaci\u00f3, nosaltres hem aconseguit que el transport electr\u00f2nic segueixi un efecte t\u00fanel directe\u201d, explica Marta Pozuelo, recentment doctorada en el grup de Pau i que ha desenvolupat l&#8217;estudi.<\/p>\n<p>Els resultats demostren que les vies de conducci\u00f3 el\u00e8ctrica de l&#8217;Azurina es poden ajustar amb molta precisi\u00f3 per mitj\u00e0 de mutacions puntuals en la part externa de la prote\u00efna, sense afectar a la seva estructura i funci\u00f3 global. \u201cHem demostrat un mecanisme estructural mitjan\u00e7ant el qual la prote\u00efna podria controlar el transport de c\u00e0rrega en molts escenaris d&#8217;inter\u00e8s biol\u00f2gic\u201d, suggereix Pau.<\/p>\n<p>Aquest contacte nanom\u00e8tric suposa a m\u00e9s una plataforma \u00fanica per estudiar els canvis en la transfer\u00e8ncia d&#8217;electrons relacionats amb l&#8217;estructura de diverses biomol\u00e8cules similars a l&#8217;azurina.<\/p>\n<p>&#8212;<\/p>\n<p><strong>Article referenciat:<\/strong> Ruiz MP, Aragon\u00e8s AC, Camarero N, Vilhena JG, Ortega M, Zotti LA, P\u00e9rez R, Cuevas JC, Gorostiza P, D\u00edez-P\u00e9rez I. (2017). <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.7b06130\" target=\"_blank\" rel=\"noopener\">Bioengineering a Single-Protein Junction<\/a>. <em>J Am Chem Soc.<\/em> 139(43):15337-15346<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><a href=\"https:\/\/ibecbarcelona.eu\/azurinjacs\/\"><img decoding=\"async\" class=\"left size-full wp-image-56660 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS.jpg\" alt=\"\" width=\"400\" height=\"209\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS-300x157.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS-230x120.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS-150x78.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/209;\" \/><\/a>El grup de l&#8217;IBEC Nanoprobes and Nanoswitches ha dissenyat un contacte el\u00e8ctric nanom\u00e8tric basat en una \u00fanica prote\u00efna. <\/h3>\n<p>A trav\u00e9s d&#8217;una subtil mutaci\u00f3 en la prote\u00efna Azurina, responsable de diversos processos metab\u00f2lics REDOX en el bacteri <em>Pseudomona Aeruginosa<\/em>, han aconseguit controlar el transport d&#8217;electrons en la biomol\u00e8cula.<\/p>\n","protected":false},"author":4,"featured_media":56660,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-56684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors de l&#039;IBEC dissenyen un contacte el\u00e8ctric amb una sola prote\u00efna - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l&#039;IBEC dissenyen un contacte el\u00e8ctric amb una sola prote\u00efna - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup de l&#039;IBEC Nanoprobes and Nanoswitches ha dissenyat un contacte el\u00e8ctric nanom\u00e8tric basat en una \u00fanica prote\u00efna.   A trav\u00e9s d&#039;una subtil mutaci\u00f3 en la prote\u00efna Azurina, responsable de diversos processos metab\u00f2lics REDOX en el bacteri Pseudomona Aeruginosa, han aconseguit controlar el transport d&#039;electrons en la biomol\u00e8cula.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-30T16:04:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-12-01T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"209\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadors de l&#8217;IBEC dissenyen un contacte el\u00e8ctric amb una sola prote\u00efna\",\"datePublished\":\"2017-11-30T16:04:47+00:00\",\"dateModified\":\"2017-12-01T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\\\/\"},\"wordCount\":362,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/azurinJACS.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-dissenyen-un-contacte-electric-amb-una-sola-proteina\\\/\",\"name\":\"Investigadors de l'IBEC dissenyen un contacte el\u00e8ctric amb una sola prote\u00efna - 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