{"id":56709,"date":"2017-12-04T10:01:49","date_gmt":"2017-12-04T09:01:49","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/deciphering-cell-language\/"},"modified":"2020-06-09T10:33:17","modified_gmt":"2020-06-09T08:33:17","slug":"deciphering-cell-language","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/deciphering-cell-language\/","title":{"rendered":"Desxifrant el llenguatge de les c\u00e8l\u00b7lules"},"content":{"rendered":"
Reconstrucci\u00f3 tridimensional de c\u00e8l\u00b7lules expressant el receptor EphB2 en la membrana de c\u00e8l\u00b7lules que han estat estimulades amb el lligant efrina. S’observa com les c\u00e8l\u00b7lules es contreuen deixant un rastre de projeccions a la base del substrat.<\/h6>\n

“Vol\u00edem entendre aquest sistema de comunicaci\u00f3, que \u00e9s molt sofisticat, al m\u00e0xim detall possible. Encara que ja coneix\u00edem els agents implicats, fins ara no ten\u00edem les eines per desxifrar el llenguatge, \u00e9s a dir, el seu mecanisme de funcionament”, comenta Samuel Ojosnegros, primer autor de l’estudi. Per estudiar els missatges que s’envien les c\u00e8l\u00b7lules, en un esfor\u00e7 conjunt entre instituts de Barcelona i de Calif\u00f2rnia, els autors han desenvolupat una nova t\u00e8cnica de microsc\u00f2pia que permet observar els senyals de comunicaci\u00f3 en c\u00e8l\u00b7lules vives. Aquesta t\u00e8cnica \u00e9s capa\u00e7 de resoldre a nivell subp\u00edxel l’agregaci\u00f3 de prote\u00efnes, que es representa amb una escala de colors, i permet registrar seq\u00fc\u00e8ncies a temps real de com una c\u00e8l\u00b7lula respon a un determinat est\u00edmul a gran resoluci\u00f3.<\/p>\n

Aquest sistema de comunicaci\u00f3 l’utilitzen les c\u00e8l\u00b7lules com una mena de GPS intern per arribar al seu dest\u00ed en els \u00f2rgans durant el desenvolupament embrionari, la regeneraci\u00f3 de c\u00e8l\u00b7lules mare i durant les met\u00e0stasis de tumors invasius.<\/p>\n

Una de les limitacions actuals de la medicina regenerativa \u00e9s la dificultat d’assegurar que les c\u00e8l\u00b7lules mare trasplantades a un pacient arribin i s’implantin al dest\u00ed desitjat. “Un cop descrit aquest mecanisme, hem fet el primer pas de cara a ser capa\u00e7os de manipular-lo per redirigir les c\u00e8l\u00b7lules mare de forma molt m\u00e9s eficient, ja que es tracta del sistema que elles utilitzen de manera natural”, apunta l’investigador del CMR[ B].<\/p>\n

Condensaci\u00f3 versus polimeritzaci\u00f3<\/strong><\/p>\n

La comunicaci\u00f3 entre c\u00e8l\u00b7lules \u00e9s un proc\u00e9s molt prec\u00eds basat en l’exist\u00e8ncia de prote\u00efnes receptores de membrana que s\u00f3n capaces de captar senyals externs de l’entorn i traduir-les a nivell intern. En l’estudi, l’equip del CMR[B] s’ha centrat en els receptors de membrana Eph i el seu lligant efrina.<\/p>\n

“Gr\u00e0cies a les nostres t\u00e8cniques de microsc\u00f2pia, hem observat que el receptor Eph, en pres\u00e8ncia d\u2019efrina, comen\u00e7a a agregar-se formant grans estructures. Aquesta agregaci\u00f3 no \u00e9s homog\u00e8nia, sin\u00f3 que segueix dos patrons diferenciats, que hem anomenat polimeritzaci\u00f3 (uni\u00f3 de mon\u00f2mers) i condensaci\u00f3 (uni\u00f3 d\u2019olig\u00f2mers). El balan\u00e7 entre aquests dos processos regula el rang din\u00e0mic de resposta, ja que si b\u00e9 la polimeritzaci\u00f3 implica l’activaci\u00f3 dels mon\u00f2mers, en la condensaci\u00f3 l’agregat \u00e9s absorbit per la c\u00e8l\u00b7lula tallant el senyal”, explica el Dr. Ojosnegros.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia: <\/strong><\/em>Ojosnegros, S., Cutrale, F., Rodr\u00edgues, D., Otterstrom, JJ., Chiu, CL., Hortig\u00fcela, V., Tarantino, C., Seriola, A., Mieruszynski, S., Martinez, E., Lakadamyali, M., Raya, A., Fraser, Se. (2017) Eph-ephrin signaling modulated by polymerization and condensation of receptors.<\/a> PNAS<\/em>, epub ahead of print<\/p>\n

Article de refer\u00e8ncia 2: <\/strong><\/em>Ver\u00f3nica Hortig\u00fcela, Enara Larra\u00f1aga, Francesco Cutrale, Anna Seriola, Mar\u00eda Garc\u00eda-D\u00edaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena Mart\u00ednez (2017) Nanopatterns of surface-bound ephrinB1 produce multivalent ligand-receptor interactions that tune EphB2 receptor clustering.<\/a> NANO Letters, epub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>Con\u00e8ixer el mecanisme de comunicaci\u00f3 intercel\u00b7lular que regula el posicionament de c\u00e8l\u00b7lules obre cam\u00ed cap al desenvolupament de ter\u00e0pies dirigides en medicina regenerativa<\/h3>\n

Con\u00e8ixer el llenguatge de les c\u00e8l\u00b7lules per poder-les redirigir cap a on sigui necessari. Aquesta \u00e9s una de les possibilitats obertes pels investigadors del Centre de Medicina Regenerativa de Barcelona (CMR[B]), liderats pel Dr. Samuel Ojosnegros, que han aconseguit descriure en el seu \u00faltim estudi el mecanisme de comunicaci\u00f3 intercel\u00b7lular implicat en el posicionament de les c\u00e8l\u00b7lules. <\/p>\n

El treball, publicat per la prestigiosa revista Proceedings of the National Academy of Sciences (PNAS) <\/em>, compta amb la col\u00b7laboraci\u00f3 dels grups d’Elena Mart\u00ednez (IBEC) i Melike Lakadamyali (ICFO), entre d’altres. La fruct\u00edfera col\u00b7laboraci\u00f3 tamb\u00e9 ha donat lloc a la publicaci\u00f3 del treball de la Ver\u00f3nica Hortig\u00fcela, ex estudiant de doctorat al grup de l’Elena, que ha dissenyat un patr\u00f3 nanom\u00e8tric de prote\u00efnes que permet controlar aquest mecanisme de comunicaci\u00f3.<\/p>\n","protected":false},"author":4,"featured_media":56703,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[820,1071],"post_formats":[],"class_list":["post-56709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-elena-martinez-ca","tag-samuel-ojosnegros-ca"],"yoast_head":"\nDesxifrant el llenguatge de les c\u00e8l\u00b7lules - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/deciphering-cell-language\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desxifrant el llenguatge de les c\u00e8l\u00b7lules - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Con\u00e8ixer el mecanisme de comunicaci\u00f3 intercel\u00b7lular que regula el posicionament de c\u00e8l\u00b7lules obre cam\u00ed cap al desenvolupament de ter\u00e0pies dirigides en medicina regenerativa Con\u00e8ixer el llenguatge de les c\u00e8l\u00b7lules per poder-les redirigir cap a on sigui necessari. Aquesta \u00e9s una de les possibilitats obertes pels investigadors del Centre de Medicina Regenerativa de Barcelona (CMR[B]), liderats pel Dr. Samuel Ojosnegros, que han aconseguit descriure en el seu \u00faltim estudi el mecanisme de comunicaci\u00f3 intercel\u00b7lular implicat en el posicionament de les c\u00e8l\u00b7lules. El treball, publicat per la prestigiosa revista Proceedings of the National Academy of Sciences (PNAS) , compta amb la col\u00b7laboraci\u00f3 dels grups d'Elena Mart\u00ednez (IBEC) i Melike Lakadamyali (ICFO), entre d'altres. 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