{"id":56979,"date":"2017-12-15T14:17:01","date_gmt":"2017-12-15T13:17:01","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=56979"},"modified":"2017-12-19T14:05:45","modified_gmt":"2017-12-19T13:05:45","slug":"els-nanomotors-enzimatics-alliberen-medicaments-contra-el-cancer-de-manera-mes-eficient","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/els-nanomotors-enzimatics-alliberen-medicaments-contra-el-cancer-de-manera-mes-eficient\/","title":{"rendered":"Els nanomotors enzim\u00e0tics alliberen medicaments contra el c\u00e0ncer de manera m\u00e9s eficient"},"content":{"rendered":"

Els investigadors mostren que els seus nanomotors (nanobots) propulsats amb ureasa s\u00f3n sistemes de subministrament eficients per al f\u00e0rmac Dox contra el c\u00e0ncer. L’an\u00e0lisi confirma que aquests nanobots mesoporosos d’estructura multicapa i fabricats amb s\u00edlice s\u00f3n capa\u00e7os d’autopropulsar-se en medis i\u00f2nics, i es va detectar un major contingut de Dox dins de les c\u00e8l\u00b7lules HeLa despr\u00e9s d’una, quatre, sis i 24 hores d’incubaci\u00f3 fent servir les nanopart\u00edcules actives en comparaci\u00f3 amb els nanomotors passius carregats amb el mateix f\u00e0rmac.<\/p>\n

“Aquesta alta efic\u00e0cia contra el c\u00e0ncer \u00e9s el resultat d’un major alliberament del f\u00e0rmac que funciona en sinergia amb l’amon\u00edac produ\u00eft en altes concentracions pel substrat d’urea”, diu el professor de recerca ICREA Samuel.<\/p>\n

La millora assolida pels nanobots propulsats per enzims en el subministrament de f\u00e0rmacs pot tenir potencial per al seu \u00fas futur en aplicacions biom\u00e8diques, com l’alliberament de f\u00e0rmacs al contacte amb substrats espec\u00edfics en ubicacions espec\u00edfiques.<\/p>\n

—<\/p>\n

Article referenciat:<\/strong> <\/em>Ana C. Hortel\u00e3o, Tania Pati\u00f1o, Ariadna Perez-Jim\u00e9nez, \u00c0ngel Blanco & Samuel S\u00e1nchez (2017). Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery. Advanced Functional Materials<\/em>, epub ahead of print.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>Investigadors de l’IBEC han demostrat que els seus nanorobots propulsats amb enzims milloren el subministrament de f\u00e0rmacs en comparaci\u00f3 amb els nanorobots passius.<\/h3>\n

L’article, publicat en Advanced Functional Materials<\/em>, \u00e9s el resultat de dos anys de recerca a l’IBEC, en els quals el grup de Samuel S\u00e1nchez<\/a> ha estat experimentant amb la cat\u00e0lisi enzim\u00e0tica per impulsar micro i nanomotors. En consumir combustibles biocompatibles, aquestes nanopart\u00edcules es poden utilitzar per a aplicacions biom\u00e8diques, com l’alliberament dirigit de f\u00e0rmacs a les c\u00e8l\u00b7lules canceroses.<\/p>\n","protected":false},"author":4,"featured_media":56937,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-56979","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nEls nanomotors enzim\u00e0tics alliberen medicaments contra el c\u00e0ncer de manera m\u00e9s eficient - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/els-nanomotors-enzimatics-alliberen-medicaments-contra-el-cancer-de-manera-mes-eficient\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Els nanomotors enzim\u00e0tics alliberen medicaments contra el c\u00e0ncer de manera m\u00e9s eficient - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC han demostrat que els seus nanorobots propulsats amb enzims milloren el subministrament de f\u00e0rmacs en comparaci\u00f3 amb els nanorobots passius. L'article, publicat en Advanced Functional Materials, \u00e9s el resultat de dos anys de recerca a l'IBEC, en els quals el grup de Samuel S\u00e1nchez ha estat experimentant amb la cat\u00e0lisi enzim\u00e0tica per impulsar micro i nanomotors. 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