{"id":57663,"date":"2018-02-08T14:38:24","date_gmt":"2018-02-08T13:38:24","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=57663"},"modified":"2018-02-12T10:52:43","modified_gmt":"2018-02-12T09:52:43","slug":"identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\/","title":{"rendered":"Identifiquen un mecanisme que regula la neurog\u00e8nesi en l’hipocamp adult"},"content":{"rendered":"
Il\u00b7lustraci\u00f3 1: Tinci\u00f3 de l’hipocamp de ratol\u00ed adult, on s’aprecia la morfologia correcta de les l\u00e0mines neuronals en l’hipocamp de l’animal control (en el panell C), i la deformaci\u00f3 en el gir dentat (fletxes) a causa de l’abs\u00e8ncia de Sema3E en el panell D.<\/h6>\n

L’estudi ha estat liderat pel Jos\u00e9 Antonio del R\u00edo, Catedr\u00e0tic de la UB, investigador principal de l’IBEC i membre de CIBERNED i de l’Institut de Neuroci\u00e8ncies de la UB. El treball s’ha realitzat en col\u00b7laboraci\u00f3 amb investigadors de l’IDIBAPS, la UB i la Universitat de Val\u00e8ncia.<\/p>\n

L’equip de del R\u00edo, amb la recentment doctorada \u00c0gata Mata i Vanessa Gil com a primeres autores, ha identificat a Sema3E i el seu receptor PlexinD1 com a prote\u00efnes que regulen la proliferaci\u00f3 de les c\u00e8l\u00b7lules mare adultes de l’hipocamp. Es tracta d’un nou rol desconegut per al binomi Sema3E \u2013 PlexinD1, que fins ara era conegut pel seu paper en la formaci\u00f3 de connexions i sinapsis espec\u00edfiques durant el desenvolupament del cervell.<\/p>\n

L’hipocamp \u00e9s una pe\u00e7a essencial per a la mem\u00f2ria a curt i llarg termini, aix\u00ed com per a la mem\u00f2ria espacial. Es localitza a l’interior del l\u00f2bul temporal del cervell, i li deu el seu nom a la seva forma anat\u00f2mica, que recorda a la del cavallet de mar (o hipocamp). En la malaltia d’Alzheimer, \u00e9s l’hipocamp una de les primeres regions cerebrals a patir danys, causant problemes de mem\u00f2ria i desorientaci\u00f3 com a part dels primers s\u00edmptomes de la malaltia.
\nDurant molt de temps, es va creure que les neurones adultes del sistema nervi\u00f3s central no podien regenerar-se, i que la p\u00e8rdua de mem\u00f2ria era un proc\u00e9s contra el qual l’organisme no era capa\u00e7 de lluitar. No obstant aix\u00f2, en els \u00faltims anys el descobriment de neurog\u00e8nesi en algunes \u00e0rees cerebrals ha trencat aquest dogma. Actualment, ja s’ha demostrat que les c\u00e8l\u00b7lules del bulb olfactori es regeneren, aix\u00ed com tamb\u00e9 ho fan les c\u00e8l\u00b7lules de l’hipocamp, en concret les de la zona subgranular (SGZ, de l’angl\u00e8s subgranular zone). En aquesta regi\u00f3 de l’hipocamp, un n\u00ednxol de c\u00e8l\u00b7lules mare s’encarrega de generar noves neurones i c\u00e8l\u00b7lules glials que posteriorment s’integren funcionalment. En els pacients d’Alzheimer, s’ha descrit que aquesta regeneraci\u00f3 funcional es troba alterada i no \u00e9s suficient com per recuperar el dany neurodegeneratiu present en la malaltia, la qual cosa contribueix, lamentablement, al deteriorament cognitiu dels pacients.<\/p>\n

En el seu \u00faltim treball, publicat recentment en la revista Scientific Reports, els investigadors de l’IBEC desxifren un nou mecanisme molecular que controla la generaci\u00f3 de noves neurones adultes en l’hipocamp. Es tracta de la prote\u00efna Sema3E i el seu receptor de membrana PlexinD1, coneguts per guiar la formaci\u00f3 de connexions i promoure la reorganitzaci\u00f3 del citosquelet neuronal durant el neurodesenvolupament.<\/p>\n

Els assajos desenvolupats en ratol\u00ed han revelat que, en abs\u00e8ncia de Sema3E o el seu receptor PlexinD1 en les neurones de l’hipocamp, es produeix una sobreproducci\u00f3 de noves neurones en els n\u00ednxols de l’hipocamp que migren de forma an\u00f2mala, provocant malformacions en aquesta \u00e0rea del cervell. Com a conseq\u00fc\u00e8ncia, les connexions neuronals i les ones gamma generades pels ratolins adults tamb\u00e9 pateixen canvis. \u201cSabem que les ones gamma tenen un paper rellevant en el manteniment del sistema nervi\u00f3s central; el nostre estudi demostra que l’abs\u00e8ncia de Sema3E o PlexinD1 en l’hipocamp podria promoure canvis patol\u00f2gics no nom\u00e9s a nivell morfol\u00f2gic, sin\u00f3 tamb\u00e9 a nivell de comportament\u201d, comenta \u00c0gata Mata, coprimera autora de l’estudi i investigadora predoctoral de l’IBEC i de la UB.
\nEl descobriment d’aquesta nova funci\u00f3 del binomi Sema3E-PlexinD1 podria llan\u00e7ar llum sobre els mecanismes implicats en la mem\u00f2ria o en el desenvolupament de tumors cerebrals causats per la proliferaci\u00f3 descontrolada de diversos tipus cel\u00b7lulars. \u201cSema3E exerceix un paper fonamental en la regulaci\u00f3 de l’hipocamp en desenvolupament i adult, tenint repercussions a nivell morfol\u00f2gic i fisiol\u00f2gic, que repercuteixen en la mem\u00f2ria a nivell conductual\u201d, afegeix Del R\u00edo.<\/p>\n

—<\/p>\n

Article referenciat: <\/strong>Agata Mata, Vanessa Gil, Jes\u00fas P\u00e9rez-Clausell, Miguel Dasilva, Mari Carmen Gonz\u00e1lez-Calixto,\u00a0Eduardo Soriano,\u00a0Jos\u00e9 Manuel Garc\u00eda-Verdugo,\u00a0Maria V. Sanchez-Vives\u00a0&\u00a0Jos\u00e9 Antonio del R\u00edo (2018). New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.<\/a> Scientific Reports<\/em> 8, 1381<\/p>\n

Aquesta recerca ha estat finan\u00e7ada pel MEICO, CIBERNED, La Fundaci\u00f3 Marat\u00f3 de Tv3, la Generalitat de Catalunya i PRIONET Spain.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>Investigadors del grup de l’IBEC Molecular and Cellular Neurobiotechnology descobreixen que la prote\u00efna Sema3E i el seu receptor PlexinD1 controlen la proliferaci\u00f3 de les c\u00e8l\u00b7lules mare adultes de l’hipocamp. <\/h3>\n

A m\u00e9s, el binomi Sema3E – PlexinD1 ha demostrat ser crucial per al correcte posicionament de les noves neurones, aix\u00ed com per al correcte desenvolupament de les seves connexions i el manteniment de les oscil\u00b7lacions gamma cerebrals que es generen en l’hipocamp adult.<\/p>\n","protected":false},"author":4,"featured_media":57625,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-57663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nIdentifiquen un mecanisme que regula la neurog\u00e8nesi en l'hipocamp adult - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifiquen un mecanisme que regula la neurog\u00e8nesi en l'hipocamp adult - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors del grup de l'IBEC Molecular and Cellular Neurobiotechnology descobreixen que la prote\u00efna Sema3E i el seu receptor PlexinD1 controlen la proliferaci\u00f3 de les c\u00e8l\u00b7lules mare adultes de l'hipocamp. A m\u00e9s, el binomi Sema3E - PlexinD1 ha demostrat ser crucial per al correcte posicionament de les noves neurones, aix\u00ed com per al correcte desenvolupament de les seves connexions i el manteniment de les oscil\u00b7lacions gamma cerebrals que es generen en l'hipocamp adult.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-08T13:38:24+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-02-12T09:52:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/02\/josedelrioscirep18.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"550\" \/>\n\t<meta property=\"og:image:height\" content=\"164\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Identifiquen un mecanisme que regula la neurog\u00e8nesi en l’hipocamp adult\",\"datePublished\":\"2018-02-08T13:38:24+00:00\",\"dateModified\":\"2018-02-12T09:52:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\\\/\"},\"wordCount\":779,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/02\\\/josedelrioscirep18.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-mecanisme-que-regula-la-neurogenesi-en-lhipocamp-adult\\\/\",\"name\":\"Identifiquen un mecanisme que regula la neurog\u00e8nesi en l'hipocamp adult - 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