{"id":58137,"date":"2018-03-20T17:09:55","date_gmt":"2018-03-20T16:09:55","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=58137"},"modified":"2018-03-22T10:03:40","modified_gmt":"2018-03-22T09:03:40","slug":"enzims-sintetics-per-a-ladministracio-controlada-de-farmacs-en-les-cel%c2%b7lules","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/enzims-sintetics-per-a-ladministracio-controlada-de-farmacs-en-les-cel%c2%b7lules\/","title":{"rendered":"Enzims sint\u00e8tics per a l’administraci\u00f3 controlada de f\u00e0rmacs en les c\u00e8l\u00b7lules"},"content":{"rendered":"
Image: Les SCPN activen la fluoresc\u00e8ncia localment (en verd) activant una mol\u00e8cula pro-fluor\u00f2for.<\/h6>\n

Les SCPN s\u00f3n objectes de nan\u00f2metres de mida inspirades en el funcionament dels enzims; carreguen un catalitzador que s’activa quan l’estructura es plega. Encara que no es tracta del primer enzim artificial que es proposa en el camp, aquest estudi \u00e9s el primer a demostrar la seva viabilitat en entorns complexos com la c\u00e8l\u00b7lula. “El blindatge que ofereixen les SCPN als catalitzadors sint\u00e8tics \u00e9s una forma no t\u00f2xica i biocompatible de contenir-los que funciona en harmonia amb el que ja est\u00e0 succeint en la c\u00e8l\u00b7lula”, diu Silvia Pujals, investigadora postdoctoral en el grup de Lorenzo Albertazzi a l’IBEC. “En altres paraules, les SCPN no interfereixen amb el comportament normal de les c\u00e8l\u00b7lules”.<\/p>\n

Les SCPN en estudi es poden administrar intracel\u00b7lular o extracel\u00b7lularment depenent de l’aplicaci\u00f3 prevista. Per a aplicacions de ter\u00e0pia fotodin\u00e0mica (PDT, Photodynamic Therapy<\/em>) es necessita una administraci\u00f3 intracel\u00b7lular, mentre que els catalitzadors organomet\u00e0l\u00b7lics funcionen b\u00e9 extracel\u00b7lularment. Aquesta \u00faltima aplicaci\u00f3 de les SCPN pot suposar un aven\u00e7 en l’alliberament controlat de medicaments. Per exemple, els enzims sint\u00e8tics podrien activar f\u00e0rmacs antitumorals subministrats a trav\u00e9s del corrent sanguini just a l’\u00e0rea del tumor. “Fins ara, hem obtingut resultats prometedors activant localment un fluor\u00f2for amb els SCPN com a catalitzadors a les \u00e0rees 1ue contenen les nanopart\u00edcules”, diu Lorenzo. “Creiem que aquestes nanopart\u00edcules similars a enzims podrien usar-se per la seva activitat pro-f\u00e0rmac en diferents aplicacions biom\u00e8diques”.<\/p>\n

—<\/p>\n

Article referenciat:<\/strong> <\/em>Yiliu Liu, Silvia Pujals, Patrick J.M. Stals, Thomas Pauloehrl, Stanislav I. Presolski, E. W. Meijer, Lorenzo Albertazzi, and Anja R.A. Palmans (2018). Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media<\/a>. J. Am. Chem. Soc.<\/em>, 140(9):3423-3433<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"El grup Nanoscopy for Nanomedicine<\/em> proposa les nanopart\u00edcules polim\u00e8riques de cadena \u00fanica (SCPN, de l’angl\u00e8s Single-Chain Polymeric Nanoparticles<\/em>) que imiten els enzims com a possibles activadores de f\u00e0rmacs en entorns biol\u00f2gics, com la c\u00e8l\u00b7lula viva.<\/h3>\n

Les nanopart\u00edcules d’inspiraci\u00f3 biol\u00f2gica podrien usar-se per controlar espacialment l’administraci\u00f3 de f\u00e0rmacs en el tractament de malalties com el c\u00e0ncer.<\/p>\n

A trav\u00e9s del seu estudi, publicat a la revista JACS<\/em>, els investigadors han optimitzat les estrat\u00e8gies d’alliberament de SCPN din\u00e0miques perqu\u00e8 conservin la seva activitat catal\u00edtica en l’entorn cel\u00b7lular. Aix\u00f2 aplana el cam\u00ed cap al disseny racional de nanosistemes que poden realitzar una cat\u00e0lisi efectiva in vivo<\/em>.<\/p>\n","protected":false},"author":4,"featured_media":58130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-58137","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nEnzims sint\u00e8tics per a l'administraci\u00f3 controlada de f\u00e0rmacs en les c\u00e8l\u00b7lules - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/enzims-sintetics-per-a-ladministracio-controlada-de-farmacs-en-les-cel\u00b7lules\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enzims sint\u00e8tics per a l'administraci\u00f3 controlada de f\u00e0rmacs en les c\u00e8l\u00b7lules - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup Nanoscopy for Nanomedicine proposa les nanopart\u00edcules polim\u00e8riques de cadena \u00fanica (SCPN, de l'angl\u00e8s Single-Chain Polymeric Nanoparticles) que imiten els enzims com a possibles activadores de f\u00e0rmacs en entorns biol\u00f2gics, com la c\u00e8l\u00b7lula viva. Les nanopart\u00edcules d'inspiraci\u00f3 biol\u00f2gica podrien usar-se per controlar espacialment l'administraci\u00f3 de f\u00e0rmacs en el tractament de malalties com el c\u00e0ncer. A trav\u00e9s del seu estudi, publicat a la revista JACS, els investigadors han optimitzat les estrat\u00e8gies d'alliberament de SCPN din\u00e0miques perqu\u00e8 conservin la seva activitat catal\u00edtica en l'entorn cel\u00b7lular. 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