{"id":58512,"date":"2018-04-19T14:57:56","date_gmt":"2018-04-19T12:57:56","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=58512"},"modified":"2018-04-23T09:49:45","modified_gmt":"2018-04-23T07:49:45","slug":"les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\/","title":{"rendered":"Les c\u00e8l\u00b7lules es comuniquen canviant el seu entorn"},"content":{"rendered":"

No solament aix\u00f2, sin\u00f3 que els canvis en la MEC desencadenats per les c\u00e8l\u00b7lules tamb\u00e9 poden propagar-se, afectant a les seves c\u00e8l\u00b7lules ve\u00efnes.<\/p>\n

Contracci\u00f3 cel\u00b7lular causant un gradient de rigidesa en una matriu extracel\u00b7lular 3D. En blau, c\u00e8l\u00b7lula MDA-MB-231. En verd, matriu de col\u00b7lagen.<\/h6>\n

Durant la seva estada de recerca en el laboratori de mecanobiologia del Roger Kamm al MIT en el per\u00edode 2015-2017, l’investigador postdoctoral de l’IBEC Andrea Malandrino va estar involucrat en el desenvolupament d’un m\u00e8tode, anomenat Microsc\u00f2pia d’Infer\u00e8ncia d’Estr\u00e8s No-lineal (NSIM, de l’angl\u00e8s Nonlinear Stress Inference Microscopy<\/em>), que revela en 3D les tensions mec\u00e0niques que les c\u00e8l\u00b7lules causen a la MEC basant-se en la mesura local de la seva rigidesa.<\/p>\n

“Hem observat que la contracci\u00f3 de les c\u00e8l\u00b7lules causa l’enduriment local de la MEC”, diu l’Andrea. “A m\u00e9s, aquests canvis locals en la rigidesa es transmeten recorrent dist\u00e0ncies que van m\u00e9s enll\u00e0 de l’\u00e0rea de la c\u00e8l\u00b7lula original. Aix\u00f2 suggereix un mecanisme espec\u00edfic a trav\u00e9s del qual les c\u00e8l\u00b7lules poden controlar el seu microentorn i comunicar-se mec\u00e0nicament entre si, podent explicar fen\u00f2mens com la durotaxis, un tipus de migraci\u00f3 cel\u00b7lular”.<\/p>\n

La comprensi\u00f3 d’aquest mecanisme podria conduir a esclarir fen\u00f2mens com l’enduriment dels teixits tumorals o les malalties fibr\u00f2tiques.<\/p>\n

—<\/p>\n

Yu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger Kamm, Martin Lenz, Chase P. Broedersz and Ming Guo (2018). Cell contraction induces long-ranged stress stiffening in the extracellular matrix<\/a>. PNAS<\/em>, publicaci\u00f3 en l\u00ednea pr\u00e8via a la publicaci\u00f3n impresa.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Els investigadors de l’IBEC i del MIT han demostrat que les c\u00e8l\u00b7lules poden fer servir el seu entorn per comunicar-se mec\u00e0nicament entre si dins dels teixits. \u00c9s com quan un soldat de l’ex\u00e8rcit tiba les cordes d’una xarxa d’entrenament perqu\u00e8 el seu company pugui ascendir amb fermesa.<\/h3>\n

Per proveir els nostres \u00f2rgans i teixits, les c\u00e8l\u00b7lules necessiten detectar i respondre constantment als est\u00edmuls mec\u00e0nics del seu entorn. En general, les c\u00e8l\u00b7lules que componen el nostre organisme estan immerses en una matriu extracel\u00b7lular (MEC), un biopol\u00edmer fet de prote\u00efnes i glicoprote\u00efnes – com el col\u00b7lagen o la fibrina. Aquesta MEC proporciona a les c\u00e8l\u00b7lules una forma d’interactuar amb altres c\u00e8l\u00b7lules, obtenir nutrients, eliminar residus i, finalment, formar teixits integrals i funcionals.<\/p>\n

Quan les c\u00e8l\u00b7lules es mouen, divideixen o diferencien, la MEC juga un paper important en la funci\u00f3 cel\u00b7lular, per la qual cosa \u00e9s vital entendre amb detall les interaccions c\u00e8l\u00b7lula-matriu. No obstant aix\u00f2, es desconeixen molts detalls sobre com les pr\u00f2pies c\u00e8l\u00b7lules afecten a la mec\u00e0nica d’aquesta matriu circumdant. <\/p>\n","protected":false},"author":4,"featured_media":58466,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-58512","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nLes c\u00e8l\u00b7lules es comuniquen canviant el seu entorn - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/les-cel\u00b7lules-es-comuniquen-canviant-el-seu-entorn\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les c\u00e8l\u00b7lules es comuniquen canviant el seu entorn - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Els investigadors de l'IBEC i del MIT han demostrat que les c\u00e8l\u00b7lules poden fer servir el seu entorn per comunicar-se mec\u00e0nicament entre si dins dels teixits. \u00c9s com quan un soldat de l'ex\u00e8rcit tiba les cordes d'una xarxa d'entrenament perqu\u00e8 el seu company pugui ascendir amb fermesa. Per proveir els nostres \u00f2rgans i teixits, les c\u00e8l\u00b7lules necessiten detectar i respondre constantment als est\u00edmuls mec\u00e0nics del seu entorn. En general, les c\u00e8l\u00b7lules que componen el nostre organisme estan immerses en una matriu extracel\u00b7lular (MEC), un biopol\u00edmer fet de prote\u00efnes i glicoprote\u00efnes - com el col\u00b7lagen o la fibrina. Aquesta MEC proporciona a les c\u00e8l\u00b7lules una forma d'interactuar amb altres c\u00e8l\u00b7lules, obtenir nutrients, eliminar residus i, finalment, formar teixits integrals i funcionals. Quan les c\u00e8l\u00b7lules es mouen, divideixen o diferencien, la MEC juga un paper important en la funci\u00f3 cel\u00b7lular, per la qual cosa \u00e9s vital entendre amb detall les interaccions c\u00e8l\u00b7lula-matriu. No obstant aix\u00f2, es desconeixen molts detalls sobre com les pr\u00f2pies c\u00e8l\u00b7lules afecten a la mec\u00e0nica d'aquesta matriu circumdant.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/les-cel\u00b7lules-es-comuniquen-canviant-el-seu-entorn\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-04-19T12:57:56+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-04-23T07:49:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/04\/celula.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"445\" \/>\n\t<meta property=\"og:image:height\" content=\"609\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Les c\u00e8l\u00b7lules es comuniquen canviant el seu entorn\",\"datePublished\":\"2018-04-19T12:57:56+00:00\",\"dateModified\":\"2018-04-23T07:49:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\\\/\"},\"wordCount\":289,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/04\\\/celula.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/les-cel%c2%b7lules-es-comuniquen-canviant-el-seu-entorn\\\/\",\"name\":\"Les c\u00e8l\u00b7lules es comuniquen canviant el seu entorn - 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