{"id":58745,"date":"2018-05-03T09:48:00","date_gmt":"2018-05-03T07:48:00","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=58745"},"modified":"2018-05-03T09:55:03","modified_gmt":"2018-05-03T07:55:03","slug":"joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\/","title":{"rendered":"Joves de cor: nova finestra temporal de regeneraci\u00f3 card\u00edaca"},"content":{"rendered":"
Imatge de la matriu extracel\u00b7lular d\u2019un cor amb capacitate de regeneraci\u00f3. En aquest cas, s\u2019ha emprat un cor de peix zebra, que permet una millor visualitzaci\u00f3. Font: CMR[B] <\/h6>\n

\u00abAra comencem a entendre que la matriu extracel\u00b7lular juga un paper important en el comportament de les c\u00e8l\u00b7lules mare i les seves aplicacions terap\u00e8utiques en medicina regenerativa\u00bb comenten els autors de l’estudi. \u00abEls esdeveniments intracel\u00b7lulars regulats per gens i prote\u00efnes sempre s’havien considerat el principal objecte d’estudi fins ara; no obstant, ens falta una visi\u00f3 m\u00e9s \u00e0mplia que englobi a tots els protagonistes de la regeneraci\u00f3 del teixit card\u00edac\u00bb.<\/p>\n

48 hores per regenerar<\/strong><\/p>\n

Fins ara, la capacitat de regeneraci\u00f3 de les c\u00e8l\u00b7lules del cor, els cardiomi\u00f2cits, s’havia associat a la seva capacitat de proliferar. Estudis anteriors permetien teoritzar que els ratolins nounats podrien ser capa\u00e7os de regenerar el seu cor despr\u00e9s d’una ferida fins a set dies despr\u00e9s de n\u00e9ixer, per\u00edode durant el qual les c\u00e8l\u00b7lules card\u00edaques encara estan en fase de desenvolupament.
\nPer primera vegada, els investigadors del CMR[B] han avaluat experimentalment la capacitat de regeneraci\u00f3 del ratol\u00ed davant d’una amputaci\u00f3 de teixit card\u00edac des de les 24 hores fins als nou dies despr\u00e9s del naixement. \u00abSi la capacitat regenerativa del cor neonatal depengu\u00e9s de la capacitat de proliferaci\u00f3 de les c\u00e8l\u00b7lules card\u00edaques, haur\u00edem vist regeneraci\u00f3 diversos dies despr\u00e9s del naixement, com s’havia teoritzat, per\u00f2 no \u00e9s aix\u00ed\u00bb, explica el Dr. Mario Notari, primer autor de l’article. \u00abEn canvi, hem acotat experimentalment aquesta finestra de regeneraci\u00f3 a dos dies, demostrant que passades 48 hores el cor perd la capacitat de regenerar-se, encara que segueixi en desenvolupament. Aix\u00ed doncs, hem desvinculat els fen\u00f2mens de regeneraci\u00f3 i proliferaci\u00f3 cel\u00b7lular dels cardiomi\u00f2cits en ratolins nounats\u00bb.<\/p>\n

La rigidesa de l’entorn, factor limitant<\/strong><\/p>\n

Gr\u00e0cies a la col\u00b7laboraci\u00f3 amb el grup de recerca IBEC-UB del Dr. Daniel Navajas, tamb\u00e9 vinculat al Centre d’Investigaci\u00f3 Biom\u00e8dica en Xarxa (CIBER), els investigadors van realitzar l’an\u00e0lisi transcript\u00f2mica i mec\u00e0nica del cor a les 24 i 48 hores de n\u00e9ixer. La principal difer\u00e8ncia observada va ser un increment significatiu de la rigidesa de matriu extracel\u00b7lular, que envolta als cardiomi\u00f2cits, als dos dies de n\u00e9ixer.<\/p>\n

Despr\u00e9s de disminuir aquesta rigidesa farmacol\u00f2gicament, l’equip d’investigaci\u00f3 va aconseguir ampliar la capacitat de regeneraci\u00f3 del cor fins a tres dies despr\u00e9s del naixement. \u00abEls nostres resultats suggereixen que la composici\u00f3 i rigidesa de la matriu extracel\u00b7lular s\u00f3n un mecanisme limitant en relaci\u00f3 a la capacitat regenerativa del cor en mam\u00edfers, per la qual cosa resulta molt interessant el seu estudi\u00bb, apunta Notari.<\/p>\n

Un nou enfocament per al tractament de malalties cardiovasculars<\/strong><\/p>\n

\u00abCon\u00e8ixer la finestra temporal de regeneraci\u00f3 del cor en nounats de manera tan espec\u00edfica facilitar\u00e0 el desenvolupament de nous estudis que permetin analitzar en profunditat els mecanismes responsables\u00bb, afegeix el Dr. \u00c1ngel Raya, director del CMR[B] i \u00faltim autor del treball. \u00abEn qualsevol cas, aquestes troballes obren una porta esperan\u00e7adora de cara al desenvolupament de noves ter\u00e0pies per a malalties cardiovasculars basades en medicina regenerativa\u00bb. A llarg termini, la disminuci\u00f3 de la rigidesa del microentorn cel\u00b7lular podria convertir-se en una ter\u00e0pia potencial per al tractament de patologies cardiovasculars.<\/p>\n

—<\/p>\n

Source article:<\/strong><\/em> Mario Notari, Antoni Ventura-Rubio, Sylvia J. Bedford-Guaus, Ignasi Jorba, Lola Mulero, Daniel Navajas, Merc\u00e8 Mart\u00ed, \u00c1ngel Raya (2018). The local microenvironment limits the regenerative potential of the mouse neonatal heart<\/a>. Science Advances<\/em>, Vol. 4, no. 5, eaao5553<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>Un nou estudi en ratolins nounats desenvolupat pel CMR[B], en col\u00b7laboraci\u00f3 amb l’IBEC i la UB, ha determinat que l’habilitat del cor per regenerar-se despr\u00e9s d’una ferida est\u00e0 relacionada la rigidesa de l’entorn cel\u00b7lular, i no nom\u00e9s amb la capacitat proliferativa de les c\u00e8l\u00b7lules card\u00edaques, acotant la finestra de regeneraci\u00f3 a 48 hores despr\u00e9s del naixement.
\n<\/h3>\n

El treball de recerca, publicat a Science Advances<\/em>, obre la porta al desenvolupament de ter\u00e0pies basades en la modificaci\u00f3 farmacol\u00f2gica de la matriu extracel\u00b7lular per fomentar la regeneraci\u00f3 de teixit despr\u00e9s d’un infart o accident card\u00edac.<\/p>\n","protected":false},"author":4,"featured_media":58733,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[759],"post_formats":[],"class_list":["post-58745","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-daniel-navajas-ca"],"yoast_head":"\nJoves de cor: nova finestra temporal de regeneraci\u00f3 card\u00edaca - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Joves de cor: nova finestra temporal de regeneraci\u00f3 card\u00edaca - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un nou estudi en ratolins nounats desenvolupat pel CMR[B], en col\u00b7laboraci\u00f3 amb l'IBEC i la UB, ha determinat que l'habilitat del cor per regenerar-se despr\u00e9s d'una ferida est\u00e0 relacionada la rigidesa de l'entorn cel\u00b7lular, i no nom\u00e9s amb la capacitat proliferativa de les c\u00e8l\u00b7lules card\u00edaques, acotant la finestra de regeneraci\u00f3 a 48 hores despr\u00e9s del naixement. El treball de recerca, publicat a Science Advances, obre la porta al desenvolupament de ter\u00e0pies basades en la modificaci\u00f3 farmacol\u00f2gica de la matriu extracel\u00b7lular per fomentar la regeneraci\u00f3 de teixit despr\u00e9s d'un infart o accident card\u00edac.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-05-03T07:48:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-05-03T07:55:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/05\/SArayaheart.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"389\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Joves de cor: nova finestra temporal de regeneraci\u00f3 card\u00edaca\",\"datePublished\":\"2018-05-03T07:48:00+00:00\",\"dateModified\":\"2018-05-03T07:55:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\\\/\"},\"wordCount\":626,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/05\\\/SArayaheart.jpg\",\"keywords\":[\"Daniel Navajas\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/joves-de-cor-nova-finestra-temporal-de-regeneracio-cardiaca\\\/\",\"name\":\"Joves de cor: nova finestra temporal de regeneraci\u00f3 card\u00edaca - 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