{"id":5956,"date":"2011-07-19T08:04:09","date_gmt":"2011-07-19T08:04:09","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/identificada-una-interaccio-essencial-per-lepilepsia\/"},"modified":"2015-01-08T16:52:13","modified_gmt":"2015-01-08T16:52:13","slug":"identificada-una-interaccio-essencial-per-lepilepsia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/identificada-una-interaccio-essencial-per-lepilepsia\/","title":{"rendered":"Identificada una interacci\u00f3 essencial per l\u2019epil\u00e8psia"},"content":{"rendered":"

Dins de l\u2019estudi, els investigadors llencen nova llum sobre la import\u00e0ncia d\u2019una prote\u00efna neuronal coneguda com PrPc, que realitza una s\u00e8rie de funcions fisiol\u00f2giques en molts processos neuronals. En mutar o plegar-se malament, la forma patog\u00e8nica de la prote\u00efna, PrPsc, provoca malalties progressives que afecten el cervell i el sistema nervi\u00f3s, com la malaltia de\u00a0 Creutzfeldt-Jakob i l\u2019EEB, mentre que en l\u2019epil\u00e8psia sembla que la prote\u00efna sana hi juga un paper preventiu.<\/p>\n

Estudis previs realitzats pel grup, que va col\u00b7laborar amb metges i especialistes en senyalitzaci\u00f3 cel\u00b7lular de Barcelona per aquest darrer article, havien mostrat que la PrPc modula l\u2019acci\u00f3 d\u2019un dels anomenats receptors de kainat, GluR6, que juga un paper decisiu en la regulaci\u00f3 de l\u2019activitat de les xarxes sin\u00e0ptiques. \u201cEl PrPc en les neurones bloqueja el receptor GluR6 i impedeix el seu enlla\u00e7 amb dues mol\u00e8cules addicionals, PSD95 i MLK3, en la sinapsis neuronal,\u201d explica Patricia Carulla del grup de Neurobiotecnologia Molecular i Cel\u00b7lular de l\u2019IBEC. \u201cL\u2019abs\u00e8ncia de PrPc, tanmateix, permet la formaci\u00f3 d\u2019aquest sistema receptor de tres mol\u00e8cules que a la seva vegada porta a l\u2019activaci\u00f3 de la via JNK3, que resulta en un augment de l\u2019epil\u00e8psia i la mortandat cel\u00b7lular a l\u2019hipocamp.\u201d<\/p>\n

Els investigadors van determinar l\u2019objectiu final de l\u2019activaci\u00f3 de la GluR6 dins de les c\u00e8l\u00b7lules treballant junt amb especialistes en senyalitzaci\u00f3 cel\u00b7lular per tal de gener imitacions in vivo de la PrPc i la JNK3. \u201cEn abs\u00e8ncia tant de la prote\u00efna PrPc com de la via JNK3, desapareix la susceptibilitat a l\u2019epil\u00e8psia experimental: la GluR6 segueix endavant i s\u2019enlla\u00e7a amb les altres dues mol\u00e8cules, per\u00f2 la fase de la JNK3 no es d\u00f3na a continuaci\u00f3,\u201d diu el responsable del grup, Jos\u00e9 Antonio del R\u00edo. \u201cAix\u00f2 mostra que la modulaci\u00f3 que la PrPc exerceix sobre l\u2019activitat de la GluR6 juga un paper clau en l\u2019activaci\u00f3 de la via que porta a la malaltia.\u201d<\/p>\n

Ara, el grup especula que un efecte protector de la PrPc semblant es pugui donar en altres danys cerebrals que comparteixen un sistema d\u2019activaci\u00f3 similar \u2013 en els que la senyalitzaci\u00f3 es transmet a trav\u00e9s de la GluR6-PSD-95-MLK3 fins la via JNK3 \u2013 tot i que faran falta m\u00e9s estudis per confirmar aix\u00f2. \u201cS\u2019ha trobat un augment en els nivells de PrPc en afectats per accidents cerebrovasculars,” diu en Jos\u00e9 Antonio. \u201cDeterminar els seus papers funcionals en les sinapsis, a m\u00e9s de les seves interaccions espec\u00edfiques en condicions normals i patol\u00f2giques podria ajudar-nos a comprendre altres malalties neurodegeneratives o els efectes de l\u2019isqu\u00e8mia (reducci\u00f3 del flux sanguini) en el cervell.\u201d<\/p>\n

Font: <\/strong>Carulla P, Bribi\u00e1n A, Rangel A, Gav\u00edn R, Ferrer I, Caelles C, Del R\u00edo JA, Llorens F. (2011). Neuroprotective role of PrPC against Kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6\/7-PSD-95 binding<\/a>. Mol Biol Cell<\/em>, in press<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Cient\u00edfics de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) descriuen un gran pas vers la comprensi\u00f3 de l\u2019epil\u00e8psia en un article publicat a Molecular Biology of the Cell.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-5956","post","type-post","status-publish","format-standard","hentry","category-noticies-de-recerca"],"yoast_head":"\nIdentificada una interacci\u00f3 essencial per l\u2019epil\u00e8psia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identificada-una-interaccio-essencial-per-lepilepsia\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificada una interacci\u00f3 essencial per l\u2019epil\u00e8psia - 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