{"id":59581,"date":"2018-06-07T11:38:00","date_gmt":"2018-06-07T09:38:00","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=59581"},"modified":"2020-06-15T12:52:44","modified_gmt":"2020-06-15T10:52:44","slug":"els-bacteris-tambe-necessiten-vitamines","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/els-bacteris-tambe-necessiten-vitamines\/","title":{"rendered":"Els bacteris tamb\u00e9 necessiten vitamines"},"content":{"rendered":"
Imatge: Model d’activitat de la ribonucle\u00f2tid reductasa (RNR) i disponibilitat de la vitamina B12 durant el creixement de biopel\u00b7l\u00edcules de P. aeruginosa. Els cercles ataronjats representen el gradient de vitamina B12, el blau indica gradients de concentraci\u00f3 d’oxigen i el verd indica activitat de la RNR de classe Ia, II i III.<\/h6>\n

Aquesta biopel\u00b7l\u00edcula no solament millora la comunicaci\u00f3 c\u00e8l\u00b7lula a c\u00e8l\u00b7lula dels bacteris, permetent que la infecci\u00f3 prosperi i creixi, sin\u00f3 que tamb\u00e9 ajuda a les c\u00e8l\u00b7lules a esquivar el sistema immunitari i augmenta les possibilitats de desenvolupar noves resist\u00e8ncies als antibi\u00f2tics.
\nEn els bacteris, com en tots els organismes vius, l’enzim ribonucle\u00f2tid reductasa (RNR) \u00e9s fonamental per a la formaci\u00f3 dels components necessaris per a la s\u00edntesi i reparaci\u00f3 de l’ADN. P. aeruginosa<\/em> \u00e9s un dels pocs bacteris que codifica les tres classes conegudes de RNR: Ia, que dep\u00e8n de l’oxigen, i II i III, que s\u00f3n actives en abs\u00e8ncia d’oxigen. Aquests tres tipus de RNR augmenten la capacitat dels bacteris per cr\u00e9ixer en diferents entorns aer\u00f2bics i anaer\u00f2bics generats en les biopel\u00b7l\u00edcules; sense ells, les biopel\u00b7l\u00edcules completament madures no podrien establir-se per si mateixes.<\/p>\n

Els investigadors han demostrat que la RNR de classe II requereix la vitamina B12 com a cofactor per funcionar correctament. “Sab\u00edem que P. aeruginosa<\/em> sintetitza la vitamina B12 en diferents reaccions metab\u00f2liques”, explica Eduard Torrents, investigador principal del grup de l’IBEC Bacterial infections: antimicrobial therapies<\/a>. “Ara hem demostrat que l’augment dels nivells de vitamina B12 durant els creixements aer\u00f2bic, estacionari i en biopel\u00b7l\u00edcula activen l’activitat de la RNR de classe II, la qual cosa significa que la pres\u00e8ncia d’aquesta vitamina \u00e9s crucial per a l’activitat de la classe de RNR essencial per a la formaci\u00f3 de biopel\u00b7l\u00edcules fins i tot en condicions adverses”.<\/p>\n

Una millor comprensi\u00f3 de com els bacteris creen biopel\u00edcul\u00b7les madures per propagar la seva infecci\u00f3 podria llan\u00e7ar llum sobre com abordar aquesta etapa del cicle de vida de la P. aeruginosa <\/em> i desenvolupar ter\u00e0pies farmacol\u00f2giques espec\u00edfiques i resistents, essencials per al tractament d’infeccions bacterianes cr\u00f2niques.<\/p>\n

—<\/p>\n

Anna Crespo, N\u00faria Blanco-Cabra and Eduard Torrents (2018). Aerobic Vitamin B12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth<\/a>. Front. Microbiol.<\/em> 9:986<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>El grup de l’IBEC Bacterial infections: antimicrobial therapies ha revelat el paper essencial que exerceix una vitamina en el desenvolupament de biopel\u00b7l\u00edcules bacterianes. <\/h3>\n

Aquest nou descobriment podria ajudar a comprendre com es propaguen aquests bacteris, la qual cosa ajudar\u00e0 a dissenyar millors f\u00e0rmacs antibacterians espec\u00edfics.<\/p>\n

L’esp\u00e8cie bacteriana P. aeruginosa<\/em> causa infeccions pulmonars cr\u00f2niques en pacients amb fibrosis qu\u00edstica o malaltia pulmonar obstructiva cr\u00f2nica (MPOC) en formar una biopel\u00b7l\u00edcula madura, on les c\u00e8l\u00b7lules s’adhereixen entre si i poden ocupar moltes superf\u00edcies diferents, la qual cosa els permet cr\u00e9ixer i adaptar-se.<\/p>\n","protected":false},"author":4,"featured_media":59537,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1141],"post_formats":[],"class_list":["post-59581","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-eduard-torrents-ca"],"yoast_head":"\nEls bacteris tamb\u00e9 necessiten vitamines - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/els-bacteris-tambe-necessiten-vitamines\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Els bacteris tamb\u00e9 necessiten vitamines - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup de l'IBEC Bacterial infections: antimicrobial therapies ha revelat el paper essencial que exerceix una vitamina en el desenvolupament de biopel\u00b7l\u00edcules bacterianes. Aquest nou descobriment podria ajudar a comprendre com es propaguen aquests bacteris, la qual cosa ajudar\u00e0 a dissenyar millors f\u00e0rmacs antibacterians espec\u00edfics. L'esp\u00e8cie bacteriana P. aeruginosa causa infeccions pulmonars cr\u00f2niques en pacients amb fibrosis qu\u00edstica o malaltia pulmonar obstructiva cr\u00f2nica (MPOC) en formar una biopel\u00b7l\u00edcula madura, on les c\u00e8l\u00b7lules s'adhereixen entre si i poden ocupar moltes superf\u00edcies diferents, la qual cosa els permet cr\u00e9ixer i adaptar-se.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/els-bacteris-tambe-necessiten-vitamines\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-07T09:38:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T10:52:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/06\/biofilm.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/els-bacteris-tambe-necessiten-vitamines\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/els-bacteris-tambe-necessiten-vitamines\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Els bacteris tamb\u00e9 necessiten vitamines\",\"datePublished\":\"2018-06-07T09:38:00+00:00\",\"dateModified\":\"2020-06-15T10:52:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/els-bacteris-tambe-necessiten-vitamines\\\/\"},\"wordCount\":410,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/els-bacteris-tambe-necessiten-vitamines\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/06\\\/biofilm.jpg\",\"keywords\":[\"Eduard Torrents\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/els-bacteris-tambe-necessiten-vitamines\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/els-bacteris-tambe-necessiten-vitamines\\\/\",\"name\":\"Els bacteris tamb\u00e9 necessiten vitamines - 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