{"id":5997,"date":"2011-08-01T12:46:41","date_gmt":"2011-08-01T12:46:41","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\/"},"modified":"2015-01-08T16:51:51","modified_gmt":"2015-01-08T16:51:51","slug":"investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\/","title":{"rendered":"Investigadors llencen nova llum en la predicci\u00f3 de la degeneraci\u00f3 dels discs intervertebrals"},"content":{"rendered":"<p> El mal d\u2019esquena est\u00e0 estretament relacionat amb l\u2019envelliment dels discos de la columna, un proc\u00e9s caracteritzat per una s\u00e8rie de canvis en la seva estructura i funci\u00f3, per\u00f2 fins ara la cadena d\u2019esdeveniments que converteix l\u2019envelliment discal normal en una malaltia degenerativa no ha estat plenament compr\u00e9s. En un article publicat avui a PLoS Computational Biology, investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) descriuen importants troballes obtingudes d\u2019observar l\u2019efecte de influ\u00e8ncies externes en discs sans i afectats. Aquestes troballes varen mostrar que el pes o la pressi\u00f3 en discs ja degenerats s\u00f3n menys efectius per als nutrients i productes cel\u00b7lulars que en discs encara sans \u2013 i que els canvis en densitat cel\u00b7lular s\u00f3n fonamentals pel proc\u00e9s de degeneraci\u00f3 discal.<\/p>\n<p>Fent servir un model computacional de l\u2019espina lumbar que t\u00e9 en compte els efectes nutricionals i mec\u00e0nics, els cient\u00edfics observaren l\u2019efecte de les c\u00e0rregues externes en dos importants soluts cel\u00b7lulars relacionats amb el metabolisme discal: oxigen i lactat. Es suposa que els canvis degeneratius estan relacionats amb una fallada en el transport de nutrients des dels vasos sanguinis perif\u00e8rics fins els discs, el que afecta a la concentraci\u00f3 d\u2019aquests soluts dins del disc i dep\u00e8n de la composici\u00f3 dels teixits i de la resposta del disc a les c\u00e0rregues mec\u00e0niques. Varen descobrir que l\u2019efecte de la c\u00e0rrega era m\u00e9s gran en comprimir un disc sa que un ja degenerat, i que fomentava fluctuacions en la concentraci\u00f3 dels soluts.<\/p>\n<p>\u201cPer al funcionament sa de la columna \u00e9s essencial que les c\u00e8l\u00b7lules discals rebin els nutrients necessaris pel manteniment dels teixits,\u201d explica l\u2019Andrea Malandrino, del grup de Biomec\u00e0nica i Mecanobiologia de l\u2019IBEC, que va dur a terme la recerca. \u201cEn un disc sa, veiem que l\u2019estr\u00e8s mec\u00e0nic sostingut \u2013 que altera la concentraci\u00f3 de soluts \u2013 afecta el transport de nutrients m\u00e9s dr\u00e0sticament que en discos que ja han degenerat, suggerint que les c\u00e0rregues en el disc sa s\u00f3n importants per mantenir l\u2019equilibri metab\u00f2lic adequat. Podem dir amb seguretat que una alteraci\u00f3 del nombre de c\u00e8l\u00b7lules causada per aquesta pertorbaci\u00f3 del transport metab\u00f2lic podria resultar en el possible inici de degeneraci\u00f3 discal.\u201d<\/p>\n<p>Amb el coneixement de que tant els patrons mec\u00e0nics com cel\u00b7lulars contribueixen a mantenir una condici\u00f3 saludable, s\u2019han obert nous camins de recerca i desenvolupament en el camp de la medicina regenerativa discal. \u201cAix\u00f2 tindr\u00e0 un gran impacte no nom\u00e9s en el camp de la modelitzaci\u00f3 espinal, sin\u00f3 en el conjunt de la modelitzaci\u00f3 en bioenginyeria, doncs destaca la import\u00e0ncia de combinar processos mec\u00e0nics i biol\u00f2gics,\u201d diu en Damien Lacroix, responsable del grup de Biomec\u00e0nica i Mecanobiologia. <\/p>\n<p>\u00a0<\/p>\n<h5>Andrea Malandrino, J\u00e9r\u00f4me Noailly, Damien Lacroix , 2011,<a href=\"http:\/\/www.ploscompbiol.org\/doi\/pcbi.1002112\">\u201cThe effect  of sustained compression on oxygen metabolic transport in the  intervertebral disc decreases with degenerative changes\u201d<\/a>. PLoS  Computational Biology<\/h5>\n<p>\u00a0<\/p>\n<p>This news has been covered on the BBC website today: <a href=\"http:\/\/www.bbc.co.uk\/news\/health-14403201\">http:\/\/www.bbc.co.uk\/news\/health-14403201<\/a><\/p>\n<p>ABC Salud coverage: <a href=\"http:\/\/www.abc.es\/salud\/noticias\/nuevo-paso-para-regeneracion-vertebral-9879.html\">http:\/\/www.abc.es\/salud\/noticias\/nuevo-paso-para-regeneracion-vertebral-9879.html<\/a><\/p>\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><img decoding=\"async\" class=\"left size-full wp-image-5993 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/08\/bbcdamien.jpg\" border=\"0\" width=\"300\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/08\/bbcdamien.jpg 444w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/08\/bbcdamien-235x300.jpg 235w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/08\/bbcdamien-117x150.jpg 117w\" data-sizes=\"(max-width: 444px) 100vw, 444px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 444px; --smush-placeholder-aspect-ratio: 444\/566;\" \/>El patiment del dolor lumbar \u00e9s, malauradament, molt familiar per moltes persones. Ara, investigadors han donat un gran pas vers la comprensi\u00f3 d\u2019una de les afeccions m\u00e9s comunes i afeblidores del m\u00f3n industrialitzat, amb resultats que podrien ajudar a predir el comen\u00e7ament de la degeneraci\u00f3 discal.<\/p>\n","protected":false},"author":4,"featured_media":5993,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-5997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors llencen nova llum en la predicci\u00f3 de la degeneraci\u00f3 dels discs intervertebrals - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors llencen nova llum en la predicci\u00f3 de la degeneraci\u00f3 dels discs intervertebrals - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El patiment del dolor lumbar \u00e9s, malauradament, molt familiar per moltes persones. Ara, investigadors han donat un gran pas vers la comprensi\u00f3 d\u2019una de les afeccions m\u00e9s comunes i afeblidores del m\u00f3n industrialitzat, amb resultats que podrien ajudar a predir el comen\u00e7ament de la degeneraci\u00f3 discal.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2011-08-01T12:46:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-01-08T16:51:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/08\/bbcdamien.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"444\" \/>\n\t<meta property=\"og:image:height\" content=\"566\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadors llencen nova llum en la predicci\u00f3 de la degeneraci\u00f3 dels discs intervertebrals\",\"datePublished\":\"2011-08-01T12:46:41+00:00\",\"dateModified\":\"2015-01-08T16:51:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\\\/\"},\"wordCount\":549,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2011\\\/08\\\/bbcdamien.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-llencen-nova-llum-en-la-prediccio-de-la-degeneracio-dels-discs-intervertebrals\\\/\",\"name\":\"Investigadors llencen nova llum en la predicci\u00f3 de la degeneraci\u00f3 dels discs intervertebrals - 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