{"id":60960,"date":"2018-08-21T13:54:09","date_gmt":"2018-08-21T11:54:09","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=60960"},"modified":"2020-06-15T11:46:45","modified_gmt":"2020-06-15T09:46:45","slug":"millors-models-in-vitro-per-estudiar-lintesti-huma","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/millors-models-in-vitro-per-estudiar-lintesti-huma\/","title":{"rendered":"Millors models in vitro per estudiar l’intest\u00ed hum\u00e0"},"content":{"rendered":"
Imatge: Representaci\u00f3 esquem\u00e0tica de la diferenciaci\u00f3 in vitro del teixit intestinal de les c\u00e8l\u00b7lules mare pluripotents.<\/h6>\n

No obstant aix\u00f2, els models actuals, que fan servir c\u00e8l\u00b7lules Caco-2 derivades de tumors intestinals humans, no s\u00f3n completament representatius de l’intest\u00ed prim hum\u00e0.<\/p>\n

L’article suggereix usar iPSCs (de l’angl\u00e8s induced Pluripotent Stem Cells) i diferenciar-les perqu\u00e8 es converteixin en c\u00e8l\u00b7lules similars a les intestinals, amb la finalitat de desenvolupar models que proporcionin millors prediccions del comportament dels nous f\u00e0rmacs. \u00abLes c\u00e8l\u00b7lules similars als enter\u00f2cits obtingudes de iPSCs tenen m\u00e9s similituds amb els enter\u00f2cits primaris que Caco-2, que \u00e9s l’est\u00e0ndard d’or’ actual\u00bb, diu la primera autora Helena Macedo, estudiant de doctorat de Porto, co-supervisada per Elena. \u00abFer servir aquestes c\u00e8l\u00b7lules en models intestinals pot permetre una correlaci\u00f3 m\u00e9s fiable amb la situaci\u00f3 que es d\u00f3na in vivo<\/em>\u00ab.<\/p>\n

No obstant aix\u00f2, encara queden diversos obstacles que salvar. Si b\u00e9 \u00e9s possible obtenir c\u00e8l\u00b7lules de tipus enter\u00f2cit a partir de iPSCs, el percentatge de c\u00e8l\u00b7lules immadures segueix sent alt, la qual cosa indica que els protocols de diferenciaci\u00f3 actuals no produeixen una poblaci\u00f3 amb el nivell requerit d’homogene\u00eftat. A m\u00e9s, mentre que les c\u00e8l\u00b7lules de tipus enter\u00f2cit derivades de iPSC mostren una major expressi\u00f3 de la majoria dels transportadors i enzims que les c\u00e8l\u00b7lules Caco-2, encara estan lluny dels nivells habituals in vivo<\/em>. Els costos i el temps associats amb la diferenciaci\u00f3 de iPSCs tamb\u00e9 suposen desavantatges.<\/p>\n

\u00abPerqu\u00e8 les iPSCs siguin vistes com una eina prometedora per als models intestinals en el futur, els protocols de diferenciaci\u00f3 haurien de millorar\u00bb, diu l’Elena Mart\u00ednez, investigadora principal del grup. \u00abAix\u00f2 augmentaria encara m\u00e9s les similituds entre aquestes c\u00e8l\u00b7lules i els enter\u00f2cits, fent-les encara m\u00e9s interessants per al seu \u00fas en models intestinals\u00bb.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/em><\/strong> Maria Helena Macedo, Francisca Ara\u00fajo, \u00a0Elena Mart\u00ednez, Cristina Barrias, and Bruno Sarmento\u00a0(2018). iPSC-Derived Enterocyte-like Cells for Drug Absorption and Metabolism Studies<\/a>. Trends in Molecular Medicine<\/em>, 24, 8, 696-708<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>El grup de l’IBEC Biomimetic Systems for Cell Engineering<\/a> ha publicat un article de revisi\u00f3 sobre noves estrat\u00e8gies per estudiar l’absorci\u00f3 de f\u00e0rmacs en l’intest\u00ed a la revista d’alt impacte Trends in Molecular Medicine<\/em>. <\/h3>\n

Juntament amb els seus col\u00b7laboradors a la Universidade do Porto, el grup d’Elena Mart\u00ednez examina l’estat de l’art dels models intestinals basats en c\u00e8l\u00b7lules, que s’han utilitzat per a estudis d’absorci\u00f3 i metabolisme de f\u00e0rmacs des de la d\u00e8cada de 1980. <\/p>\n","protected":false},"author":4,"featured_media":60894,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[820],"post_formats":[],"class_list":["post-60960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-elena-martinez-ca"],"yoast_head":"\nMillors models in vitro per estudiar l'intest\u00ed hum\u00e0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/millors-models-in-vitro-per-estudiar-lintesti-huma\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Millors models in vitro per estudiar l'intest\u00ed hum\u00e0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup de l'IBEC Biomimetic Systems for Cell Engineering ha publicat un article de revisi\u00f3 sobre noves estrat\u00e8gies per estudiar l'absorci\u00f3 de f\u00e0rmacs en l'intest\u00ed a la revista d'alt impacte Trends in Molecular Medicine. Juntament amb els seus col\u00b7laboradors a la Universidade do Porto, el grup d'Elena Mart\u00ednez examina l'estat de l'art dels models intestinals basats en c\u00e8l\u00b7lules, que s'han utilitzat per a estudis d'absorci\u00f3 i metabolisme de f\u00e0rmacs des de la d\u00e8cada de 1980.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/millors-models-in-vitro-per-estudiar-lintesti-huma\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-21T11:54:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T09:46:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/08\/ElenaTrendsposs-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"203\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/millors-models-in-vitro-per-estudiar-lintesti-huma\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/millors-models-in-vitro-per-estudiar-lintesti-huma\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Millors models in vitro per estudiar l’intest\u00ed hum\u00e0\",\"datePublished\":\"2018-08-21T11:54:09+00:00\",\"dateModified\":\"2020-06-15T09:46:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/millors-models-in-vitro-per-estudiar-lintesti-huma\\\/\"},\"wordCount\":371,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/millors-models-in-vitro-per-estudiar-lintesti-huma\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/08\\\/ElenaTrendsposs-1.jpg\",\"keywords\":[\"Elena Martinez\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/millors-models-in-vitro-per-estudiar-lintesti-huma\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/millors-models-in-vitro-per-estudiar-lintesti-huma\\\/\",\"name\":\"Millors models in vitro per estudiar l'intest\u00ed hum\u00e0 - 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