{"id":6134,"date":"2011-11-04T13:24:10","date_gmt":"2011-11-04T13:24:10","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/noticies-en-imatges-el-ball-de-les-celmlules-minuet-o-ska\/"},"modified":"2015-01-08T16:50:43","modified_gmt":"2015-01-08T16:50:43","slug":"noticies-en-imatges-el-ball-de-les-celmlules-minuet-o-ska","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/noticies-en-imatges-el-ball-de-les-celmlules-minuet-o-ska\/","title":{"rendered":"Not\u00edcies en imatges: \u201cEl ball de les c\u00e8l\u00b7lules: minuet o ska?\u201d"},"content":{"rendered":"\n<p>L\u2019objectiu d\u2019aquesta col\u00b7laboraci\u00f3 \u00e9s comprendre com el moviment de cada c\u00e8l\u00b7lula d\u2019un grup determina la seva migraci\u00f3 col\u00b7lectiva, un mecanisme intr\u00ednsec a processos com la regeneraci\u00f3 de teixits o la met\u00e0stasi cancerosa. \u201cFa temps que sospit\u00e0vem que cada c\u00e8l\u00b7lula exerceix for\u00e7a no nom\u00e9s sobre la seva matriu extracel\u00b7lular sin\u00f3 sobre les c\u00e8l\u00b7lules ve\u00efnes,\u201d explica el responsable de grup de l\u2019IBEC Xavier Trepat.<\/p>\n<p>La plitotaxi, que prov\u00e9 del grec plithos, que vol dir multitud o eixam, descriu el que v\u00e0rem descobrir en inventar una forma de mesurar aquestes forces: que cada c\u00e8l\u00b7lula empeny i estira les seves ve\u00efnes en un \u2018ball\u2019 ca\u00f2tic, i tanmateix movent cooperativament tot el conjunt en la direcci\u00f3 desitjada.\u201d \u201cQuan pensem en processos col\u00b7lectius en biologia, solem imaginar que el moviment de cada c\u00e8l\u00b7lula est\u00e0 perfectament sincronitzat amb el de les seves ve\u00efnes, com si ball\u00e9ssin un minuet. Ben al contrari, hem descobert que aquest \u2018ball\u2019 \u00e9s m\u00e9s semblant a l\u2019ska, desordenat i violent.\u201d<\/p>\n<p>L\u2019imatge mostra el citoesquelet o \u2018bastida\u2019 d\u2019un grup de c\u00e8l\u00b7lules epitelials migrat\u00f2ries (l\u2019epiteli \u00e9s una membrana d\u2019una o m\u00e9s capes de c\u00e8l\u00b7lules que cobreix la majoria de les superf\u00edcies del cos, inclosos els \u00f2rgans). Algunes de les c\u00e8l\u00b7lules estan marcades fent servir codis de colors per mostrar com poden existir difer\u00e8ncies extremes de for\u00e7a dins de la l\u00e0mina.<\/p>\n<p>Donat que la migraci\u00f3 cel\u00b7lular, en la que grups de c\u00e8l\u00b7lules es desplacen llargues dist\u00e0ncies sense perdre la seva cohesi\u00f3, \u00e9s fonamental per a que els teixits puguin regenerar-se i, per altra banda, un factor important en la propagaci\u00f3 del c\u00e0ncer, el treball dels investigadors podria portar a importants aven\u00e7os en la predicci\u00f3 del moviment de les c\u00e8l\u00b7lules canceroses.<\/p>\n<p>\u00a0<\/p>\n<p><strong>Image \u00a9 Xavier Serra\/IBEC. Font: <\/strong>Trepat, X and Fredberg, J.J. (2011). <a href=\"http:\/\/www.cell.com\/trends\/cell-biology\/abstract\/S0962-8924%2811%2900127-9\">Plithotaxis and emergent dynamics in collective cellular migration<\/a>. Trends in Cell Biology, 21(11), 638-646<\/p>\n<p>Descarregueu una versi\u00f3 d\u2019aquesta imatge en alta resoluci\u00f3 desde \u2028<a href=\"images\/stories\/transfer\/ticb_21-11_cover_midblue.jpg\">http:\/\/<\/a><a href=\"images\/stories\/transfer\/ticb_21-11_cover_midblue.jpg\">www.ibecbarcelona.eu<\/a><a href=\"images\/stories\/transfer\/ticb_21-11_cover_midblue.jpg\">\/images\/stories\/transfer\/ticb_21-11_cover_midblue.jpg<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><img decoding=\"async\" class=\"left size-full wp-image-6130 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/11\/ticb_21-11_cover_midblueweb.jpg\" border=\"0\" width=\"600\" height=\"503\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/11\/ticb_21-11_cover_midblueweb.jpg 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/11\/ticb_21-11_cover_midblueweb-300x251.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/11\/ticb_21-11_cover_midblueweb-178x150.jpg 178w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2011\/11\/ticb_21-11_cover_midblueweb-150x125.jpg 150w\" data-sizes=\"(max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/503;\" \/><\/p>\n<p>Aquesta imatge, que apareix a la portada de novembre de la revista d\u2019alt impacte Trends in Cell Biology, il\u00b7lustra el treball d\u2019investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) que varen col\u00b7laborar amb cient\u00edfics de Harvard per definir un nou concepte en biologia, la plitotaxi.<\/p>\n","protected":false},"author":4,"featured_media":6130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-6134","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Not\u00edcies en imatges: \u201cEl ball de les c\u00e8l\u00b7lules: minuet o ska?\u201d - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/noticies-en-imatges-el-ball-de-les-celmlules-minuet-o-ska\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" 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