{"id":61370,"date":"2018-09-13T10:01:28","date_gmt":"2018-09-13T08:01:28","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=61370"},"modified":"2020-06-09T13:45:10","modified_gmt":"2020-06-09T11:45:10","slug":"el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\/","title":{"rendered":"El nou grup de l’IBEC crea ‘mapes d’impacte’ de mutacions gen\u00e8tiques"},"content":{"rendered":"

“Les prote\u00efnes que s’agreguen formant amiloides s\u00f2lids, o fibril\u00b7les, s’associen amb una s\u00e8rie de condicions neurodegeneratives, per\u00f2 ara sabem que aquestes prote\u00efnes, que s\u00f3n t\u00f2xiques, tamb\u00e9 poden formar agregats l\u00edquids”, comenta Bolognesi.<\/p>\n

El seu grup de l’IBEC desenvolupar\u00e0 i expandir\u00e0 un m\u00e8tode conegut com escombrat mutacional profund, que quantifica milers de mutacions proteiques bones i dolentes alhora per produir un “mapa d’impacte” de les mutacions. “Amb l’escaneig mutacional a gran escala, podem “mapejar” milers de mutacions en dominis proteics similars als prions – un exemple d’agregat amiloide que causa malalties neurodegeneratives – i despr\u00e9s jugar amb les concentracions i combinacions per veure quins tenen un impacte en la salut”, diu Benedetta. “Aquest m\u00e8tode a gran escala ens ajudar\u00e0 a descobrir com i en quines circumst\u00e0ncies les mutacions poden resultar en afeccions devastadores com l’Alzheimer o l’esclerosi lateral amiotr\u00f2fica”.<\/p>\n

L’inter\u00e8s de la Benedetta en els agregats de prote\u00efnes va comen\u00e7ar quan estava fent el seu doctorat a Cambridge amb el professor Chris Dobson, fundador del Cambridge Center for Misfolding Diseases<\/a>, que va ser nomenat cavaller aquest any. En aquell moment, ella estava buscant amiloides en relaci\u00f3 amb la malaltia d’Alzheimer. “Despr\u00e9s del meu doctorat volia abordar preguntes m\u00e9s generals, per la qual cosa al CRG vaig decidir treballar amb models computacionals i llevats amb una beca interdisciplin\u00e0ria compartida entre dos laboratoris”, diu. “A trav\u00e9s d’aquesta experi\u00e8ncia, em vaig interessar en com la seq\u00fc\u00e8ncia de les prote\u00efnes determina la formaci\u00f3 d’agregats l\u00edquids enfront d’agregats s\u00f2lids, i en l’impacte que aix\u00f2 pot tenir en la salut i la malaltia”.<\/p>\n

A l’IBEC, Bolognesi compartir\u00e0 amb el grup Molecular and cellular neurobiotechnology<\/a> – liderat per Jos\u00e9 Antonio del R\u00edo – la missi\u00f3 de comprendre les malalties neurodegeneratives, i espera col\u00b7laborar amb molts altres grups. “De fet, vaig coincidir amb el Lorenzo Albertazzi<\/a> a la Universitat de Pavia”, comenta Benedetta. “M’agradaria treballar amb ell i amb el Pau Gorostiza<\/a>, per les seves capacitats en microsc\u00f2pia STORM i AFM. Tamb\u00e9 estic interessada a col\u00b7laborar amb grups que treballen amb c\u00e8l\u00b7lules mare o l\u00ednies cel\u00b7lulars de mam\u00edfers amb l’objectiu de realitzar proves en models m\u00e9s complexos que el llevat”.<\/p>\n

Quan no est\u00e0 treballant, a la Benedetta li agrada anar a caminar a la muntanya. La investigadora comenta que est\u00e0 encantada de formar part de l’IBEC, tant pel seu entorn interdisciplinari i els seus equipaments com pel fet que Barcelona \u00e9s “un fant\u00e0stic lloc per a la ci\u00e8ncia biom\u00e8dica”.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>La tardor arriba a l’IBEC amb la incorporaci\u00f3 de la Dra. Benedetta Bolognesi a la comunitat, unint-se a l’institut com a investigadora principal junior.<\/h3>\n

Benedetta ve del Centre de Regulaci\u00f3 Gen\u00f2mica de Barcelona, on va ser postdoc en els grups de Ben Lehner i Gian Gaetano Tartaglia. A l’IBEC, dirigir\u00e0 el grup recentment fundat Protein Phase Transitions in Health and Disease<\/a>.<\/p>\n

Durant el seu postdoc, Benedetta es va centrar a estudiar per qu\u00e8 certs gens s\u00f3n t\u00f2xics quan es sobreexpressen. Ella va descobrir que, en alguns casos, causen toxicitat perqu\u00e8 les prote\u00efnes que codifiquen acaben formant una fase l\u00edquida diferent en el citoplasma.<\/p>\n","protected":false},"author":4,"featured_media":61269,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[],"post_formats":[],"class_list":["post-61370","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals"],"yoast_head":"\nEl nou grup de l'IBEC crea 'mapes d'impacte' de mutacions gen\u00e8tiques - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El nou grup de l'IBEC crea 'mapes d'impacte' de mutacions gen\u00e8tiques - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La tardor arriba a l'IBEC amb la incorporaci\u00f3 de la Dra. 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Ella va descobrir que, en alguns casos, causen toxicitat perqu\u00e8 les prote\u00efnes que codifiquen acaben formant una fase l\u00edquida diferent en el citoplasma.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-13T08:01:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-09T11:45:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/09\/benedetta_news.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"333\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"El nou grup de l’IBEC crea ‘mapes d’impacte’ de mutacions gen\u00e8tiques\",\"datePublished\":\"2018-09-13T08:01:28+00:00\",\"dateModified\":\"2020-06-09T11:45:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\\\/\"},\"wordCount\":450,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/09\\\/benedetta_news.jpg\",\"articleSection\":[\"Not\u00edcies institucionals\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/el-nou-grup-de-libec-crea-mapes-dimpacte-de-mutacions-genetiques\\\/\",\"name\":\"El nou grup de l'IBEC crea 'mapes d'impacte' de mutacions gen\u00e8tiques - 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