{"id":63395,"date":"2018-11-16T09:50:26","date_gmt":"2018-11-16T08:50:26","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=63395"},"modified":"2020-06-15T11:42:05","modified_gmt":"2020-06-15T09:42:05","slug":"els-investigadors-de-libec-revelen-una-estrategia-per-reduir-els-efectes-secundaris-de-la-quimioterapia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/els-investigadors-de-libec-revelen-una-estrategia-per-reduir-els-efectes-secundaris-de-la-quimioterapia\/","title":{"rendered":"Els investigadors de l’IBEC revelen una estrat\u00e8gia per reduir els efectes secundaris de la quimioter\u00e0pia"},"content":{"rendered":"

Una manera de resoldre-ho seria dissenyar rutes per garantir que els medicaments administrats en la quimioter\u00e0pia nom\u00e9s s’activin quan arribin a l’objectiu desitjat. Investigadors del grup de Nanoprobes i Nanoswitches<\/a> de l’IBEC, que s\u00f3n pioners en l’\u00fas de la llum per activar i desactivar remotament l’acci\u00f3 dels medicaments i altres mol\u00e8cules, acaben de revelar a la revista JACS que aquesta possibilitat existeix.<\/p>\n

En el seu estudi, els investigadors presenten el fototrexat, una mol\u00e8cula que es pot activar i desactivar remotament mitjan\u00e7ant la llum i que actua com a inhibidor de la dihidrofolat reductasa (DHFR), un enzim ubic que t\u00e9 un paper essencial en la regulaci\u00f3 de la proliferaci\u00f3 i el creixement de les c\u00e8l\u00b7lules. Aix\u00ed, el fototrexat es podria usar com a variant controlada per la llum del metotrexat, un medicament d’\u00e0mplia prescripci\u00f3 en quimioter\u00e0pia i utilitzat per al tractament del c\u00e0ncer i la psoriasi.<\/p>\n

El fototrexat es va provar en el peix zebra \u2013un organisme model que \u00e9s \u00fatil per la seva estructura gen\u00e8tica, similar a la de l’\u00e9sser hum\u00e0\u2013 i es va demostrar que bloqueja s\u00f2lidament la DHFR en la seva configuraci\u00f3 fotoactivada, per\u00f2 que queda pr\u00e0cticament inactiu en la seva forma fosca o “relaxada”. <\/p>\n

“El fototrexat constitueix la demostraci\u00f3 conceptual del disseny de mol\u00e8cules citot\u00f2xiques regulades per la llum”, afirma Carlo Matera, investigador del grup de Nanoprobes and Nanoswitches de l’IBEC i primer autor de l’article. “El nostre descobriment representa un pas decisiu vers el desenvolupament de fotoquimioter\u00e0pies antic\u00e0ncer personalitzades amb una efic\u00e0cia localitzada i amb reducci\u00f3 dels efectes secundaris.”<\/p>\n

—
\nCarlo Matera, Alexandre M. J. Gomila, N\u00faria Camarero, Michela Libergoli, Concepci\u00f3 Soler, and Pau Gorostiza (2018). Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy.<\/a> JACS<\/em>, just accepted manuscript<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadors de l’IBEC i d’IDIBELL han desenvolupat una mol\u00e8cula regulada amb llum que podria millorar els tractaments de quimioter\u00e0pia en controlar l’activitat dels agents antic\u00e0ncer.<\/h3>\n

La quimioter\u00e0pia (l’\u00fas d’agents citot\u00f2xics per matar r\u00e0pidament les c\u00e8l\u00b7lules que proliferen en els tumors) \u00e9s una de les armes principals en la lluita contra el c\u00e0ncer. Malgrat aix\u00f2, la seva efectivitat i la toler\u00e0ncia del cos a aquesta t\u00e8cnica sovint estan enormement limitades: a banda de les \u00e0rees canceroses, tamb\u00e9 pot afectar \u00e0rees sanes i provocar efectes secundaris. <\/p>\n","protected":false},"author":4,"featured_media":63387,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1150],"post_formats":[],"class_list":["post-63395","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-pau-gorostiza-ca"],"yoast_head":"\nEls investigadors de l'IBEC revelen una estrat\u00e8gia per reduir els efectes secundaris de la quimioter\u00e0pia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/els-investigadors-de-libec-revelen-una-estrategia-per-reduir-els-efectes-secundaris-de-la-quimioterapia\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Els investigadors de l'IBEC revelen una estrat\u00e8gia per reduir els efectes secundaris de la quimioter\u00e0pia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC i d'IDIBELL han desenvolupat una mol\u00e8cula regulada amb llum que podria millorar els tractaments de quimioter\u00e0pia en controlar l'activitat dels agents antic\u00e0ncer. 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