{"id":63602,"date":"2018-12-09T14:09:38","date_gmt":"2018-12-09T13:09:38","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/iproteos-ibec-and-vhir-to-develop-an-innovative-therapy-against-solid-tumors\/"},"modified":"2023-03-30T09:46:57","modified_gmt":"2023-03-30T07:46:57","slug":"iproteos-ibec-and-vhir-to-develop-an-innovative-therapy-against-solid-tumors","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/iproteos-ibec-and-vhir-to-develop-an-innovative-therapy-against-solid-tumors\/","title":{"rendered":"Iproteos, l\u2019IBEC i el VHIR desenvoluparan una innovadora ter\u00e0pia contra els tumors s\u00f2lids"},"content":{"rendered":"\n

\u2022 El projecte \u2013que ha rebut 935.000\u20ac en la convocat\u00f2ria Retos-Colaboraci\u00f3n 2017<\/a>\u2013 se centrar\u00e0, en una primera fase, en dos dels tumors s\u00f2lids m\u00e9s freq\u00fcents en nens i adolescents, rabdomiosarcoma i neuroblastoma, aix\u00ed com en c\u00e0ncer de pulm\u00f3 i c\u00f2lon, els de major incid\u00e8ncia i mortalitat en adults.<\/p>\n\n\n\n

Un mecanisme d\u2019acci\u00f3 antitumoral innovador<\/strong><\/p>\n\n\n\n

Investigadors del Grup de Mecanobiologia Cel\u00b7lular i Molecular de l\u2019IBEC, liderats per Pere Roca-Cusachs, van descobrir que la uni\u00f3 de les prote\u00efnes Talina i Vinculina \u2013 desencadenada per la for\u00e7a mec\u00e0nica exercida per les c\u00e8l\u00b7lules en resposta a un augment de la rigidesa del seu teixit circumdant \u2013activa un important oncogen anomenat YAP<\/a>, present en la majoria dels tumors s\u00f2lids. Els resultats de la recerca\u2013 publicada a Nature Cell Biology<\/em> el 2016<\/a>\u2013 van revelar que la inhibici\u00f3 de la interacci\u00f3 d\u2019ambdues prote\u00efnes prev\u00e9 l\u2019activaci\u00f3 de l\u2019oncogen YAP i t\u00e9 el potencial d\u2019alentir, aturar o fins i tot revertir el creixement tumoral.<\/p>\n\n\n\n

\u201cEn comptes d\u2019enfocar-nos en mutacions gen\u00e8tiques o factors bioqu\u00edmics, proposem atacar els tumors basant-nos en les seves propietats mec\u00e0niques, que estan fortament alterades. Aix\u00f2 representa una estrat\u00e8gia completament nova en ter\u00e0pia del c\u00e0ncer, que podria potencialment ser revolucion\u00e0ria, i fer-se servir en combinaci\u00f3 amb altres ter\u00e0pies m\u00e9s convencionals, explica el Dr. Roca-Cusachs.<\/p>\n\n\n\n

La biotecnol\u00f2gica Iproteos abordar\u00e0 el disseny, s\u00edntesi i caracteritzaci\u00f3 de les mol\u00e8cules inhibidores de la interacci\u00f3 d\u2019ambdues prote\u00efnes, Talina i Vinculina, mitjan\u00e7ant la seva plataforma IPROTech, una tecnologia d’\u00faltima generaci\u00f3 que combina eines de qu\u00edmica computacional (in silico<\/em>) amb biotecnol\u00f2giques (in vitro<\/em>) per accelerar el disseny d\u2019una nova generaci\u00f3 de f\u00e0rmacs basats en p\u00e8ptids.<\/p>\n\n\n\n

\u201cEl nou mecanisme d\u2019acci\u00f3 antitumoral descobert pel grup de Pere Roca-Cusachs \u00e9s de gran rellev\u00e0ncia, at\u00e8s la seva prevalen\u00e7a en la majoria de tumors s\u00f2lids malignes, els m\u00e9s freq\u00fcents en oncologia. Es tracta, aix\u00ed doncs, d\u2019un projecte amb un gran potencial, ja que abasta un ampli mercat que demana nous f\u00e0rmacs innovadors que puguin ajudar a millorar les taxes de superviv\u00e8ncia actuals. La nostra plataforma IPROTech<\/a> tindr\u00e0 un paper fonamental, ja que ens permet obtenir f\u00e0rmacs per a dianes complicades, com les interaccions prote\u00efna-prote\u00efna\u201d, revela Teresa Tarrag\u00f3, cofundadora i CEO d\u2019Iproteos.<\/p>\n\n\n\n

El Grup de Recerca Traslacional en C\u00e0ncer en la Inf\u00e0ncia i l’Adolesc\u00e8ncia del VHIR, dirigit pel Dr. Josep S\u00e1nchez de Toledo i la Dra. Soledad Gallego, avaluar\u00e0 in vitro i in vivo en tumors pedi\u00e0trics els efectes anti-oncog\u00e8nics dels f\u00e0rmacs candidats, una investigaci\u00f3 que ser\u00e0 liderada des del VHIR pel Dr. Josep Roma. L’obtenci\u00f3 de resultats sobre biodisponibilitat, farmacocin\u00e8tica i farmacodin\u00e0mica ser\u00e0 clau en el desenvolupament del projecte, a m\u00e9s de crucial per iniciar les proves de concepte amb la dosi \u00f2ptima.<\/p>\n\n\n\n

\u201cPoder tirar endavant aquest projecte, obre una nova via molt prometedora per al desenvolupament de nous f\u00e0rmacs basats en mecanismes biol\u00f2gics altament innovadors per a la lluita contra c\u00e0ncer. A m\u00e9s, poder obrir aquesta l\u00ednia de recerca tamb\u00e9 en tumors de la inf\u00e0ncia, d\u00f3na un elevat valor afegit al projecte, doncs sovint la investigaci\u00f3 per a desenvolupar nous f\u00e0rmacs se centra exclusivament en tumors de l\u2019adult i deixa de banda els tumors en els infants. Els tumors s\u00f2lids infantils inclosos en aquest estudi presenten encara una superviv\u00e8ncia clarament per sota de la mitjana per als c\u00e0ncers infantils i, per tant, \u00e9s molt necessari estudiar noves vies de tractament per tal de millorar-ne les taxes de superviv\u00e8ncia\u201d, afirma el Dr. Josep Roma.<\/p>\n\n\n\n

El projecte, anomenat \u201cDesenvolupament d’una ter\u00e0pia innovadora per al tractament dels tumors s\u00f2lids mitjan\u00e7ant la inhibici\u00f3 de la mecanotransducci\u00f3\u201d, d\u2019un any de durada, ha rebut un ajut de 935.000 euros del Ministeri de Ci\u00e8ncia, Innovaci\u00f3 i Universitats, a trav\u00e9s de la convocat\u00f2ria Retos-Colaboraci\u00f3n 2017 del \u2018Programa Estatal de I+D+i Orientada a los Retos de la Sociedad\u2019 (Exp. RTC-2017-6505-1).<\/p>\n\n\n\n

Aquest projecte est\u00e0 cofinan\u00e7at a trav\u00e9s dels fons FEDER de la Uni\u00f3 Europea amb el principal objectiu de promoure el desenvolupament tecnol\u00f2gic, la innovaci\u00f3 i una recerca de qualitat.<\/p>\n\n\n

\n
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\"\"\u2022\tLa biotecnol\u00f2gica Iproteos i l\u2019Institut de Bioenginyeria de Catalunya (IBEC), ubicats al Parc Cient\u00edfic de Barcelona (PCB), i el Vall d’Hebron Institut de Recerca (VHIR) desenvoluparan un innovador tractament per alentir, aturar i, fins i tot, revertir el creixement dels tumors s\u00f2lids, que representen m\u00e9s del 90% dels casos de c\u00e0ncer.<\/h3>\n

\u2022\tEs tracta d\u2019una fam\u00edlia de f\u00e0rmacs peptidomim\u00e8tics basats en un mecanisme d\u2019acci\u00f3 antitumoral totalment nou, fruit d\u2019una llarga traject\u00f2ria investigadora del grup de Pere Roca-Cusachs<\/a> de l\u2019IBEC. <\/p>\n

\u2022\tEl Grup de Recerca Traslacional en C\u00e0ncer en la Inf\u00e0ncia i l’Adolesc\u00e8ncia<\/a> del VHIR avaluar\u00e0 in vitro<\/em> i in vivo<\/em> en tumors pedi\u00e0trics l\u2019efic\u00e0cia dels f\u00e0rmacs candidats, desenvolupats mitjan\u00e7ant la tecnologia IPROTech d\u2019Iproteos<\/a>.<\/p>\n","protected":false},"author":4,"featured_media":63593,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1134],"post_formats":[],"class_list":["post-63602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-pere-roca-cusachs-ca"],"yoast_head":"\nIproteos, l\u2019IBEC i el VHIR desenvoluparan una innovadora ter\u00e0pia contra els tumors s\u00f2lids - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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totalment nou, fruit d\u2019una llarga traject\u00f2ria investigadora del grup de Pere Roca-Cusachs de l\u2019IBEC. \u2022 El Grup de Recerca Traslacional en C\u00e0ncer en la Inf\u00e0ncia i l'Adolesc\u00e8ncia del VHIR avaluar\u00e0 in vitro i in vivo en tumors pedi\u00e0trics l\u2019efic\u00e0cia dels f\u00e0rmacs candidats, desenvolupats mitjan\u00e7ant la tecnologia IPROTech d\u2019Iproteos.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/iproteos-ibec-and-vhir-to-develop-an-innovative-therapy-against-solid-tumors\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-09T13:09:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-30T07:46:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/ibec_iproteos_web.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" 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