{"id":64456,"date":"2018-12-24T11:35:25","date_gmt":"2018-12-24T10:35:25","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/"},"modified":"2020-06-15T11:39:45","modified_gmt":"2020-06-15T09:39:45","slug":"two-promising-avenues-in-the-fight-against-antibiotic-resistance","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/","title":{"rendered":"Dues vies prometedores en la lluita contra la resist\u00e8ncia als antibi\u00f2tics"},"content":{"rendered":"<p>Grups de recerca com el de l&#8217;<a href=\"https:\/\/ibecbarcelona.eu\/ca\/bactinf\">Eduard Torrents<\/a>, subvencionat en part per beques de l&#8217;Obra Social \u201cla Caixa\u201d, estan treballant en diversos m\u00e8todes per superar la resist\u00e8ncia dels bacteris, com ara desenvolupar nous medicaments adre\u00e7ats a noves dianes o b\u00e9 interferir en els plasmidis que atorguen la resist\u00e8ncia contra els antibi\u00f2tics actuals.<\/p>\n<p>En una publicaci\u00f3 a la revista <em>ACS Omega<\/em>, amb col\u00b7laboradors de la UB, la UAB i la Universitat de Kwazulu-Natal de Sud-\u00c0frica, el grup ha desvelat que els derivats de la hidroxilamina podrien convertir-se en uns nous i prometedors agents en la lluita contra els bacteris pat\u00f2gens resistents als medicaments. Els compostos, coneguts com a N-HA (compostos N-substitu\u00efts d&#8217;hidroxilamina, un h\u00edbrid d&#8217;amon\u00edac i aigua), es poden concebre i sintetitzar amb activitat antibacteriana. Despr\u00e9s, poden actuar com a \u201ccarronyaires radicals\u201d per inhibir la ribonucle\u00f2tid reductasa (RNR), un enzim bacteri\u00e0 que \u00e9s essencial per a la proliferaci\u00f3 dels bacteris durant una infecci\u00f3, perqu\u00e8 proporciona el pilar fonamental per a la s\u00edntesi i la reparaci\u00f3 de l&#8217;ADN. Aquest enzim es podria considerar com un nou objectiu antibacteri\u00e0 a l&#8217;hora de tractar les infeccions per bacteris.<\/p>\n<p>El treball ha demostrat la poca toxicitat dels compostos en l&#8217;hoste i l&#8217;efecte antimicrobi\u00e0 contra diversos bacteris i ha provat que redu\u00efen la massa d&#8217;un biofilm determinat (l&#8217;entorn en el qual els bacteris poden cr\u00e9ixer i adaptar-se, de manera que es creen les condicions adequades per a una infecci\u00f3) en bacteris causants de malalties, inclosos la <em>Pseudomonas aeruginosa<\/em>, l&#8217;<em>Staphylococcus aureus<\/em> i l&#8217;<em>Escherichia coli<\/em>.<\/p>\n<p>El segon estudi, publicat en la revista d&#8217;alt impacte <em>Journal of Medicinal Chemistry<\/em> amb col\u00b7laboradors d&#8217;\u00c0ustria, Nova Zelanda, Hongria, S\u00e8rbia, Singapur i la Rep\u00fablica Eslovaca, descriu un altre agent prometedor que tamb\u00e9 podria presentar propietats anticancer\u00edgenes.<\/p>\n<p>Se sap que la morfolina ha mostrat una acci\u00f3 anticancer\u00edgena (s&#8217;utilitza en diversos medicaments comercialitzats) i els investigadors han sintetitzat h\u00edbrids de morfolina-tiosemicarbazona i complexos de coure(II) soluble en aigua que han proporcionat un clar efecte antibacteri\u00e0, en inhibir l&#8217;RNR a trav\u00e9s d&#8217;un proc\u00e9s conegut com a <em>quelaci\u00f3 del ferro intracel\u00b7lular<\/em>. Aquests compostos amb propietats anticancer\u00edgenes i antibacterianes ofereixen el doble benefici d&#8217;afectar simult\u00e0niament la malignitat del c\u00e0ncer alhora que disminueixen el risc d&#8217;infecci\u00f3 bacteriana, que pot ser sovint una causa de mort en pacients de c\u00e0ncer immunocompromesos.<\/p>\n<p>\u201cL&#8217;emerg\u00e8ncia i la creixent prevalen\u00e7a de les soques bacterianes que s\u00f3n resistents als antibi\u00f2tics disponibles exigeixen que es descobreixin plantejaments terap\u00e8utics com aquests\u201d, declara l&#8217;Eduard. \u201cHem de fer tot el que puguem ara per retardar el dia en qu\u00e8 pugui ser massa perill\u00f3s dur a terme procediments cl\u00ednics com els trasplantaments d&#8217;\u00f2rgans, la quimioter\u00e0pia o la cura d&#8217;infants prematurs.\u201d<\/p>\n<p>&#8212;<\/p>\n<p>Laia Miret-Casals, Aida Baelo, Esther Juli\u00e1n, Josep Astola, Ariadna Lobo-Ruiz, Fernando Albericio, and Eduard Torrents (2018). <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.8b01384\">Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents. <\/a><em>ACS Omega<\/em> 3 (12), pp 17057\u201317069<\/p>\n<p>Kateryna Ohui, Eleonora Afanasenko, Felix Bacher, Rachel Lim Xue Ting, Ayesha Zafar, Nuria Blanco-Cabra, Eduard Torrents, Orsolya Domotor, Nora V. May, Denisa Darvasiova, Eva A Enyedy, Ana D. Popovi\u0107-Bijeli\u0107, Johannes Reynisson, Peter Rapta, Maria Babak, Giorgia Pastorin, and Vladimir B. Arion (2018).<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.8b01031\">Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents. <\/a> New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. <em>J. Med. Chem.<\/em>, Just Accepted Manuscript<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" width=\"450\" height=\"348\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2018\/12\/J-med-chem-cover-picture_web.png\" alt=\"\" class=\"wp-image-64316 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/12\/J-med-chem-cover-picture_web.png 450w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/12\/J-med-chem-cover-picture_web-300x232.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/12\/J-med-chem-cover-picture_web-168x130.png 168w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/12\/J-med-chem-cover-picture_web-150x116.png 150w\" data-sizes=\"(max-width: 450px) 100vw, 450px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 450px; --smush-placeholder-aspect-ratio: 450\/348;\" \/>El grup Infeccions bacterianes: ter\u00e0pies antimicrobianes de l&#8217;IBEC ha publicat dos articles en qu\u00e8 ofereix noves esperances per a la recerca urgent d&#8217;antimicrobians.<\/h3>\n<p>\u201cNecessitem antimicrobians desesperadament\u201d, afirma l&#8217;investigador principal del grup, Eduard Torrents. \u201cLa resist\u00e8ncia als antibi\u00f2tics \u00e9s una de les amenaces actuals m\u00e9s importants per a la salut humana, i ja s&#8217;acosta el moment en qu\u00e8 tota una s\u00e8rie de procediments rutinaris poden tornar-se molt m\u00e9s arriscats&#8221;. No nom\u00e9s algunes infeccions o malalties comunes s&#8217;han tornar resistents als antibi\u00f2tics que habitualment s&#8217;usaven per tractar-les, sin\u00f3 que ara s&#8217;hi afegeix un problema m\u00e8dic altament urgent: el r\u00e0pid augment dels anomenats \u201csuperbacteris\u201d o bacteris multi resistents, que s\u00f3n immunes a pr\u00e0cticament tots els antibi\u00f2tics que tenim actualment al nostre abast.<\/p>\n","protected":false},"author":4,"featured_media":64317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1141],"post_formats":[],"class_list":["post-64456","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-eduard-torrents-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dues vies prometedores en la lluita contra la resist\u00e8ncia als antibi\u00f2tics - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dues vies prometedores en la lluita contra la resist\u00e8ncia als antibi\u00f2tics - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup Infeccions bacterianes: ter\u00e0pies antimicrobianes de l&#039;IBEC ha publicat dos articles en qu\u00e8 ofereix noves esperances per a la recerca urgent d&#039;antimicrobians. \u201cNecessitem antimicrobians desesperadament\u201d, afirma l&#039;investigador principal del grup, Eduard Torrents. \u201cLa resist\u00e8ncia als antibi\u00f2tics \u00e9s una de les amenaces actuals m\u00e9s importants per a la salut humana, i ja s&#039;acosta el moment en qu\u00e8 tota una s\u00e8rie de procediments rutinaris poden tornar-se molt m\u00e9s arriscats&quot;. No nom\u00e9s algunes infeccions o malalties comunes s&#039;han tornar resistents als antibi\u00f2tics que habitualment s&#039;usaven per tractar-les, sin\u00f3 que ara s&#039;hi afegeix un problema m\u00e8dic altament urgent: el r\u00e0pid augment dels anomenats \u201csuperbacteris\u201d o bacteris multi resistents, que s\u00f3n immunes a pr\u00e0cticament tots els antibi\u00f2tics que tenim actualment al nostre abast.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-24T10:35:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T09:39:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/12\/J-med-chem-cover-picture_web.png\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"348\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Dues vies prometedores en la lluita contra la resist\u00e8ncia als antibi\u00f2tics\",\"datePublished\":\"2018-12-24T10:35:25+00:00\",\"dateModified\":\"2020-06-15T09:39:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\\\/\"},\"wordCount\":592,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/12\\\/J-med-chem-cover-picture_web.png\",\"keywords\":[\"Eduard Torrents\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\\\/\",\"name\":\"Dues vies prometedores en la lluita contra la resist\u00e8ncia als antibi\u00f2tics - 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