{"id":6489,"date":"2012-06-19T07:45:14","date_gmt":"2012-06-19T07:45:14","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/com-el-nas-sho-olora\/"},"modified":"2015-01-08T15:41:24","modified_gmt":"2015-01-08T15:41:24","slug":"com-el-nas-sho-olora","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/com-el-nas-sho-olora\/","title":{"rendered":"Com s\u2019ho ensuma el nas"},"content":{"rendered":"

En l\u2019article que apareix avui a PlosOne, els investigadors aborden un obstacle actual per a una millor comprensi\u00f3 del sistema olfactiu dels mam\u00edfers, en concret, com es codifica i processa la informaci\u00f3 qu\u00edmica. Per fer aix\u00f2, van estudiar el rendiment del sistema olfactiu perif\u00e8ric de les rates a l\u2019hora d\u2019identificar el tipus dels est\u00edmuls entrants \u2013 \u00e9s a dir, la seva capacitat de detectar i distingir diferents olors \u2013 i van fer un an\u00e0lisi dels resultats quantificant el n\u00famero d\u2019olors que podien ser codificats per un conjunt particular de receptors olfactius (ROs) del sistema.<\/p>\n

\u201cLes neurones RO en el sistema s\u00f3n de diversos tipus i estan distribu\u00efdes per l\u2019epiteli nasal de forma complexa. A m\u00e9s a m\u00e9s el n\u00famero de tipus dep\u00e8n de l\u2019esp\u00e8cie; per exemple, hi ha 387 tipus diferents de ROs en els humans, i 1.035 en els ratolins,\u201d explica en Santiago Marco, responsable del grup d\u2019Olfacci\u00f3 Artificial de l\u2019IBEC. \u201cVam observar el paper que jugava aquesta diversitat i el n\u00famero total de receptors en la codificaci\u00f3 de la informaci\u00f3 qu\u00edmica.\u201d<\/p>\n

La recerca pr\u00e8via ha mostrat que un sistema olfactiu particular s\u2019adapta a les propietats estad\u00edstiques del conjunt de subst\u00e0ncies qu\u00edmiques a les quals es veu exposat \u2013 per exemple, els ROs d\u2019un gos estaran m\u00e9s sintonitzats amb l\u2019olor de la carn que els de un conill. Com que diferents neurones responen a un conjunt d\u2019olors diferents, aix\u00f2 forma la base del \u201ccodi\u201d pel qual s\u2019identifiquen les olors, i aix\u00ed els investigadors van classificar els receptors olfactius de les rates segons el seu rang de recepci\u00f3 (RR) quan se\u2019ls exposa a un gran n\u00famero d\u2019olors \u2013 una immensa proesa de mapejat sistem\u00e0tic, a causa del gran nombre de receptors que es troben en les rates i la enorme quantitat de lligands potencials. Tamb\u00e9 van estudiar la capacitat de distingir depenent de la distribuci\u00f3, i la correlaci\u00f3 entre receptors. A m\u00e9s a m\u00e9s, en lloc de utilitzar\u00a0 models te\u00f2rics simplificats, van fer servir dades reals del bulb olfactori procedents d\u2019una extensa base de dades proporcionada per la Universitat de California Irvine. <\/p>\n

\u201dVam descobrir que el rendiment \u00f2ptim correspon a un conjunt de receptors amb un abast de recepci\u00f3 del 50%, aix\u00ed que els Ros no s\u00f3n particularment selectius,\u201d diu en Santiago. \u201cTot i aix\u00ed, el sistema biol\u00f2gic te una correlaci\u00f3 o solapament dels sensors notablement baixa, i una bona cobertura de l\u2019espai olfactiu. Per sensors amb baixa correlaci\u00f3, afegir-ne m\u00e9s al conjunt maximitza la capacitat de codificaci\u00f3 del sistema.\u201d<\/p>\n

A partir d\u2019aix\u00f2, els investigadors suposen que la biologia ha evolucionat envers una combinaci\u00f3 de sensors m\u00e9s selectius per a les olors cr\u00edtiques i una col\u00b7lecci\u00f3 de sensors menys selectius per a cobrir \u00e0rees m\u00e9s grans de l\u2019espai olfactiu. \u201cUn cas extrem d\u2019aquest impuls evolutiu \u00e9s la pres\u00e8ncia de sensors altament espec\u00edfics per a la detecci\u00f3 de feromones,\u201d afegeix en Santiago. \u201cAquesta millor comprensi\u00f3 de la codificaci\u00f3 de les olors en l\u2019olfacci\u00f3 pot oferir valuoses informacions per al disseny de sistemes d\u2019olfacci\u00f3 artificial multiusos; per exemple, abans es creia que els sensors qu\u00edmics no s\u00f3n prou selectius, per\u00f2 el nostre estudi mostra que potser la selectivitat no sigui el par\u00e0metre m\u00e9s rellevant.\u201d <\/p>\n

\u00a0<\/p>\n

—<\/p>\n

J. Fonollosa, A. Gutierrez-Galvez, S. Marco (2012). Quality Coding by Neural Populations in the Early Olfactory Pathway: Analysis using Information Theory and lessons for Artificial Olfactory Systems. PLoS ONE, in press. http:\/\/dx.plos.org\/10.1371\/journal.pone.0037809<\/a><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

El sentit de l\u2019olfacte dels mam\u00edfers \u00e9s un excel\u00b7lent sistema de detecci\u00f3 qu\u00edmica que sobrepassa de lluny qualsevol reproducci\u00f3 feta per la m\u00e0 de l\u2019home. Aix\u00ed, fa molt de temps que els investigadors intenten analitzar i recrear el sistema olfactiu animal per desenvolupar \u201cnassos\u201d artificials. Ara, investigadors de l\u2019IBEC han fet nous descobriments sobre aquest sistema tan eficient que podrien permetre el desenvolupament de millors sistemes de detecci\u00f3 qu\u00edmica amb importants aplicacions en \u00e0rees tan essencials com la salut, la seguretat o la ind\u00fastria aliment\u00e0ria.<\/p>\n","protected":false},"author":4,"featured_media":6487,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-6489","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nCom s\u2019ho ensuma el nas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/com-el-nas-sho-olora\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Com s\u2019ho ensuma el nas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El sentit de l\u2019olfacte dels mam\u00edfers \u00e9s un excel\u00b7lent sistema de detecci\u00f3 qu\u00edmica que sobrepassa de lluny qualsevol reproducci\u00f3 feta per la m\u00e0 de l\u2019home. 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