{"id":6543,"date":"2012-07-11T08:43:11","date_gmt":"2012-07-11T08:43:11","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/qfitxantq-objectes-i-virus-a-la-nanoescala\/"},"modified":"2015-01-08T15:32:40","modified_gmt":"2015-01-08T15:32:40","slug":"qfitxantq-objectes-i-virus-a-la-nanoescala","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/qfitxantq-objectes-i-virus-a-la-nanoescala\/","title":{"rendered":"“Fitxant” objectes i virus a la nanoescala"},"content":{"rendered":"

En el seu article “Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces”, la Laura Fumagalli, el responsable del grup Gabriel Gomila i els seus companys presenten el seu treball en una nova t\u00e8cnica per identificar nano-objectes com ara virus sense necessitat d\u2019etiquetatge, el que podria ser un gran aven\u00e7 per al diagn\u00f2stic biom\u00e8dic, la protecci\u00f3 del medi ambient i la nanoelectr\u00f2nica.<\/p>\n

El grup ha superat les limitacions que existeixen actualment en la identificaci\u00f3 i caracteritzaci\u00f3 basades en l\u2019EFM mesurant la constant diel\u00e8ctrica, o permitivitat, dels objectes. Aix\u00f2 d\u00f3na una indicaci\u00f3 de com reacciona el material del que est\u00e0 fet un objecte a l\u2019aplicaci\u00f3 d\u2019un camp el\u00e8ctric. En augmentar la resoluci\u00f3 el\u00e8ctrica del microscopi en gaireb\u00e9 dos ordres de magnitud, per a poder detectar forces ultrafebles i fent servir nano-puntes geom\u00e8tricament estables, a m\u00e9s d\u2019un m\u00e8tode prec\u00eds de modelitzar els seus resultats que t\u00e9 en compte la f\u00edsica d\u2019un sistema i tots els seus elements geom\u00e8trics, van ser capa\u00e7os de quantificar amb precisi\u00f3 les constants diel\u00e8ctriques, i de fer-les servir a mode d\u2019\u201cempremtes dactilars\u201d. Aix\u00f2 els va permetre distingir objectes amb forma id\u00e8ntica per\u00f2 diferent composici\u00f3, que serien impossibles de recon\u00e8ixer sense etiquetar.<\/p>\n

\u201cAnteriorment, l\u2019EFM nom\u00e9s podia distingir entre nano-objectes met\u00e0l\u00b7lics i no met\u00e0l\u00b7lics en experiments en blanc i negre,\u201d explica la Laura, autora principal de l\u2019estudi. \u201cAra hem reconegut quantitativament aquells que estan fets amb materials molt similars i amb constants diel\u00e8ctriques baixes, com \u00e9s el cas de molts complexos biol\u00f2gics.\u201d<\/p>\n

\u201cEl nostre m\u00e8tode, una forma no invasiva de determinar l\u2019estat intern dels objectes i de correlacionar-los amb les seves funcions sense tallar o etiquetar, ser\u00e0 una eina valuos\u00edssima per diverses \u00e0rees de la recerca cient\u00edfica,\u201d diu en Gabriel Gomila, coautor de l\u2019estudi i un dels responsables de grup de l\u2019IBEC. \u201c\u00c9s especialment important en la nanomedicina per diagn\u00f2stics biom\u00e8dics, doncs obre la porta a la detecci\u00f3 quantitativa sense etiquetes de macromol\u00e8cules biol\u00f2giques com els virus, basant-se en les seves propietats diel\u00e8ctriques.\u201d <\/p>\n

Els investigadors han aplicat la seva t\u00e8cnica a importants complexos biol\u00f2gics, com els virus. En desentranyar per primer cop les propietats diel\u00e8ctriques d\u2019aquests nano-objectes, que fins ara havien estat inaccessibles, potser puguin descobrir importants aspectes de la funcionalitat d\u2019un virus. Amb la seva t\u00e8cnica, van distingir entre virus buits i portadors d\u2019ADN, per exemple, que s\u00f3n els que poden inserir el seu material gen\u00e8tic en l\u2019ADN d\u2019una c\u00e8l\u00b7lula hoste.<\/p>\n

\u201cAquests resultats s\u00f3n tamb\u00e9 un gran aven\u00e7 en l\u2019estudi fonamental de la diel\u00e8ctrica a la nanoescala, que aporta els blocs de construcci\u00f3 que determinen el rendiment de la nova generaci\u00f3 de dispositius nanoelectr\u00f2nics disponible avui en dia,\u201d afegeix la Laura. \u201cLa nostra nova t\u00e8cnica promet llan\u00e7ar llum sobre q\u00fcestions com les propietats diel\u00e8ctriques de nanocomposts i nanodispositius h\u00edbrids desenvolupats recentment, i ens poden dir quina \u00e9s l\u2019escala m\u00e9s petita en la qual un objecte diel\u00e8ctric pot conservar les seves propietats \u2013 en altres paraules, fins on podem reduir.\u201d<\/p>\n

Per llegir l\u2019article, consulteu la web de Nature Materials aqu\u00ed<\/a>. <\/p>\n

—<\/p>\n

Cobertura als mitjans:<\/p>\n

http:\/\/www.lswn.it\/comunicati\/stampa\/2012\/riconoscimento_nano_oggetti_e_virus_senza_marcatori<\/a><\/p>\n

http:\/\/www.sciencedaily.com\/releases\/2012\/07\/120709093046.htm<\/a><\/p>\n

http:\/\/phys.org\/news\/2012-07-scientists-fingerprint-nanoscale-viruses.html<\/a><\/p>\n

http:\/\/www.teinteresa.es\/salud\/Investigadores-espanoles-descubren-celulas-empujones_0_733727017.html<\/a><\/p>\n

http:\/\/www.nanowerk.com\/news2\/newsid=25853.php<\/a><\/p>\n

http:\/\/www.stonehearthnewsletters.com\/virus-detection-technologies-get-even-smaller-which-is-a-good-thing\/infectious-diseases\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

El grup de Caracteritzaci\u00f3 Bioel\u00e8ctrica a la Nanoescala de l\u2019IBEC celebra aquesta setmana la publicaci\u00f3 dels seus darrers resultats a la revista Nature Materials<\/em>.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-6543","post","type-post","status-publish","format-standard","hentry","category-noticies-de-recerca"],"yoast_head":"\n"Fitxant" objectes i virus a la nanoescala - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/qfitxantq-objectes-i-virus-a-la-nanoescala\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\""Fitxant" objectes i virus a la nanoescala - 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